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Gene · 5693

PSMB5: proteasome 20S subunit beta 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMB5: proteasome 20S subunit beta 5. Genes, record 5693. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5693

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Gene

Symbol
PSMB5
HGNC
Name
proteasome 20S subunit beta 5
HGNC
NCBI Gene ID
5693
NCBI Gene
HGNC ID
HGNC:9542
HGNC
Ensembl
ENSG00000100804
NCBI Gene
Aliases
LMPX, MB1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P28074Proteasome subunit beta type-5263156Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459534P28074Espacenet
EP 4650780 A22025-11-198048P28074Espacenet
EP 4641202 A22025-10-295358P28074Espacenet
US 12433933 B22025-10-0714P28074Espacenet
JP 2025517970 A2025-06-128048P28074Espacenet
KR 1020250017231 A2025-02-045358P28074Espacenet
JP 2024009871 A2024-01-2369P28074Espacenet
US 11771740 B22023-10-0314P28074Espacenet
US 11446398 B22022-09-2067915P28074Espacenet
JP 2022533303 A2022-07-2214P28074Espacenet

1 to 10 of 41

See all 41 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants1,004

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMB5 papersNewest fiscal year
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control102025
P01CA155258Integrative Oncogenomics of Multiple Myeloma62025
P30CA008748Cancer Center Support Grant42025
P30CA015704Cancer Center Support Grant42025
P50CA186781Mayo Clinic Multiple Myeloma SPORE42025
P50CA098252SPORE in Cervical Cancer32025
R35GM130234Chemical Biology of Cell Division32025
T32CA193201Integrative Training in Oncogenic Signaling32025
I01BX001584Molecular Manipulation to Enhance Anti-Myeloma Response22025
K12HD052896Child Health Research Career Development Award (CHRCDA) Program (K12)22025

1 to 10 of 1,004Source NIH's project files

See all 1,004 nih grants

Papers1,295

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ultramutagenesis through Combined Msh2 Depletion and Proofreading-Deficient DNA Polymerase ε Expression Enhances Small-Molecule Target Identification in Forward Genetic Screens.ACS Chem Biol202642723219PubTator, text miningPubMed
SADS-CoV Nsp1 hijacks proteasomal subunits to degrade IRF1.Vet Microbiol202642721780PubTator, text miningPubMed
Proteasome Dysfunction in Basal Keratinocytes Drives Epidermal Disruption and Dermal Inflammation.Am J Pathol202642674183PubTator, text miningPubMed
Air pollution and hepatocellular carcinoma: Integrated network toxicology, machine learning, molecular docking and multiomics analysis.Oncol Lett202642428344PubTator, text miningPubMed
Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screens.bioRxiv202642427792PubTator, text miningPubMed
Proteomics analysis of empagliflozin in patients without diabetes or overt heart failure from empagliflozin and cardiac remodeling in people without diabetes CardioLink-7 randomized clinical trial.Cardiovasc Endocrinol Metab202642367684PubTator, text miningPubMed
EphB4 inhibition defines a druggable synthetic-lethal vulnerability in MYC-driven triple-negative breast cancer.Cell Death Dis202642362505PubTator, text miningPubMed
Proteome Profiling Reveals NQO2 Activity Contributing to Proteasome Inhibitor Resistance in Multiple Myeloma Cell Lines.Mol Cell Proteomics202642362189PubTator, text miningPubMed
Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors.NPJ Precis Oncol202642303761PubTator, text miningPubMed
Integrative Pan-Cancer Mapping of Proteasome Dependency Prioritizes PSMB5 and PSMB6 as Context-Dependent Vulnerability Biomarkers Linked to Immune Context.Molecules202642280256PubTator, text miningPubMed

1 to 10 of 1,295

See all 1,295 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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