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Gene · 5694

PSMB6: proteasome 20S subunit beta 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMB6: proteasome 20S subunit beta 6. Genes, record 5694. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5694

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Gene

Symbol
PSMB6
HGNC
Name
proteasome 20S subunit beta 6
HGNC
NCBI Gene ID
5694
NCBI Gene
HGNC ID
HGNC:9543
HGNC
Ensembl
ENSG00000142507
NCBI Gene
Aliases
DELTA, LMPY, Y
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P28072Proteasome subunit beta type-6239146Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192751P28072Espacenet
EP 4641202 A22025-10-294634P28072Espacenet
JP 2025517970 A2025-06-122751P28072Espacenet
KR 1020250017231 A2025-02-044634P28072Espacenet
US 11860162 B22024-01-021236P28072Espacenet
US 11564998 B22023-01-315007P28072Espacenet
US 11446398 B22022-09-2067920P28072Espacenet
JP 2022524081 A2022-04-27170891P28072Espacenet
US 11078247 B22021-08-039066P28072Espacenet
US 10746735 B22020-08-181236P28072Espacenet

1 to 10 of 31

See all 31 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants473

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMB6 papersNewest fiscal year
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control72025
P30CA044579University of Virginia Cancer Center Support Grant32025
P50CA186781Mayo Clinic Multiple Myeloma SPORE32025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA023108Cancer Center Support Grant22025
P30CA030199Cancer Center Support Grant (CCSG)22025
P50CA058223SPORE in Breast Cancer22025
R01GM131641Mapping endogenous protein dynamics in living cells22025
T32CA009109Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies22025
T32ES018827Research Training in Environmental Toxicology22025

1 to 10 of 473Source NIH's project files

See all 473 nih grants

Papers696

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
An Investigation to Study Morphology, Nanomechanical Attributes, Transcriptomics, and Proteomics of Tumor Associated Macrophages Derived Extracellular Vesicles in the Tumor Microenvironment.J Anal Oncol202642719843PubTator, text miningPubMed
The pterocarpan (+)-PTC modulates cytoskeletal proteins and induces apoptosis in metastatic castration-resistant prostate cancer: a proteomic perspective.Front Pharmacol202642318340PubTator, text miningPubMed
Integrative Pan-Cancer Mapping of Proteasome Dependency Prioritizes PSMB5 and PSMB6 as Context-Dependent Vulnerability Biomarkers Linked to Immune Context.Molecules202642280256PubTator, text miningPubMed
Ubiquitination and degradation of CD47 enhances macrophage phagocytosis of hemolytic erythrocytes.iScience202641568156PubTator, text miningPubMed
Zinc-Related Proteasome Variants in Type 1 Diabetes: An in Silico-Guided Case-Control Study.Metabolites202541441015PubTator, text miningPubMed
Deep learning and multi-omics reveal programmed cell death-associated diagnostic signatures and prognostic biomarkers in gastric cancer.Front Immunol202541293156PubTator, text miningPubMed
[Protein biomarker screening and functional analysis of salivary exosomes in patients with ulcerative colitis].Beijing Da Xue Xue Bao Yi Xue Ban202541131760PubTator, text miningPubMed
Predictive value of MHC-related genes in cervical cancer: implications for immunotherapy and prognostic nomogram development.Discov Oncol202540888998PubTator, text miningPubMed
Gene signatures associated with exosomes as diagnostic markers of postpartum depression and their role in immune infiltration.Front Endocrinol (Lausanne)202540747300PubTator, text miningPubMed
Proteasome caspase-like activity regulates stress granules and proteasome condensates.Front Cell Dev Biol202540538982PubTator, text miningPubMed

1 to 10 of 696

See all 696 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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