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Gene · 56947

MFF: mitochondrial fission factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MFF: mitochondrial fission factor. Genes, record 56947. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/56947

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Gene

Symbol
MFF
HGNC
Name
mitochondrial fission factor
HGNC
NCBI Gene ID
56947
NCBI Gene
HGNC ID
HGNC:24858
HGNC
Ensembl
ENSG00000168958
NCBI Gene
Aliases
C2orf33, EMPF2, GL004
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9GZY8Mitochondrial fission factor3420Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-042607Q9GZY8Espacenet
US 12371689 B22025-07-292607Q9GZY8Espacenet
JP 2025032204 A2025-03-1131505Q9GZY8Espacenet
EP 4461818 A22024-11-1331505Q9GZY8Espacenet
JP 2023058610 A2023-04-2531505Q9GZY8Espacenet
US 11446398 B22022-09-2051825Q9GZY8Espacenet
US 11400116 B22022-08-024615Q9GZY8Espacenet
JP 2022524081 A2022-04-27154796Q9GZY8Espacenet
JP 2020508652 A2020-03-2631505Q9GZY8Espacenet
JP 2017121240 A2017-07-1351855Q9GZY8Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,119

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMFF papersNewest fiscal year
R35GM122545The impact of dynamic actin polymerization on mitochondrial dynamics and function72025
P20GM113132The Institute for Biomolecular Targeting62025
P30CA014195Cancer Center Support Grant (CCSG)62025
R01GM125844Defining Molecular Interactions that Drive Mitochondrial Fission62025
ZIANS003123Role of mitochondria in neurodegenerative diseases52025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes42025
R01AA011147Ethanol and aldehyde dehydrogenases in health and disease42025
P30CA010815Consolidated Basic Cancer Research Program32025
P30CA012197Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 1,119Source NIH's project files

See all 1,119 nih grants

Papers1,634

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mitochondrial Quality Control: A Gatekeeper of Spermatogenesis.J Vis Exp202642813713PubTator, text miningPubMed
Recent advances in mitochondrial fission and fusion in diabetic cardiomyopathy.Front Cardiovasc Med202642761440PubTator, text miningPubMed
Mitochondrial fission factor senses and governs ferroptosis.Nature202642749797PubTator, text miningPubMed
Spire1 and active INF2 promote ER-mitochondria contacts to enhance mitochondrial fission factor-mediated mitochondrial fission.FEBS J202642741824PubTator, text miningPubMed
The identification of Drp1 patient mutations that limit interactions with Mff.Mol Biol Cell202642555829PubTator, text miningPubMed
Mitochondrial-derived vesicles drive budding-type fission of damaged lysosomes.Nat Cell Biol202642477140PubTator, text miningPubMed
AMPK activation by AICAR mitigates hypoxic corneal damage through rebuilding energy and metabolic homeostasis.Chem Biol Interact202642392248PubTator, text miningPubMed
Role of recombinant S100A13 expression in regulating mitochondrial fission and fusion in lung epithelial cells.BBA Adv202642328016PubTator, text miningPubMed
Unraveling the effector mechanism of citrulline on sow lactation and offspring growth: an integrative multi-omics analysis.J Anim Sci Biotechnol202642298669PubTator, text miningPubMed
MFF Promotes Aggressive Phenotypes and Immunosuppression in Lung Adenocarcinoma via Mitochondrial Dysregulation.Curr Med Chem202642220150PubTator, text miningPubMed

1 to 10 of 1,634

See all 1,634 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/56947

GET https://conductscience.org/api/genes/v1/56947/patents