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Gene · 5699

PSMB10: proteasome 20S subunit beta 10

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMB10: proteasome 20S subunit beta 10. Genes, record 5699. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5699

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Gene

Symbol
PSMB10
HGNC
Name
proteasome 20S subunit beta 10
HGNC
NCBI Gene ID
5699
NCBI Gene
HGNC ID
HGNC:9538
HGNC
Ensembl
ENSG00000205220
NCBI Gene
Aliases
IMD121, LMP10, MECL1, MGC1665, PRAAS5, beta2i
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P40306Proteasome subunit beta type-1027316Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459529P40306Espacenet
EP 4650780 A22025-11-197555P40306Espacenet
WO 2025190963 A12025-09-185P40306Espacenet
JP 2025517970 A2025-06-127555P40306Espacenet
US 11446398 B22022-09-2067901P40306Espacenet
JP 2022524081 A2022-04-27170872P40306Espacenet
US 11078247 B22021-08-039062P40306Espacenet
JP 2019054813 A2019-04-11239964P40306Espacenet
EP 3403091 A12018-11-21686P40306Espacenet
JP 2017121241 A2017-07-13239964P40306Espacenet

1 to 10 of 21

See all 21 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
MARIZOMIBCHEMBL37140520S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,241

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,241

See all 1,241 trials

NIH grants1,299

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMB10 papersNewest fiscal year
P30CA008748Cancer Center Support Grant102025
P30CA016672Cancer Center Support Grant102025
P30CA023108Cancer Center Support Grant62025
R01AI143714Selective Plasmodium proteasome inhibitors as novel multi-stage antimalarials62025
P50CA097190Head and Neck Cancer SPORE52025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases42025
R01AR041398Novel Molecular Biomarkers of Bone Microarchitecture42025
T32DA017629Prevention and Methodology Training42025
U19AG055373Trans-omics Integration of Multi-omics Studies for Osteoporosis42025
P30CA016520Abramson Cancer Center Support Grant32025

1 to 10 of 1,299Source NIH's project files

See all 1,299 nih grants

Papers1,534

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MLN4924 suppresses kidney renal clear cell carcinoma progression through coordinated inhibition of Cullin1 neddylation and PSMB10-associated NF-κB inflammatory signaling.Inflamm Res202642802181PubTator, text miningPubMed
A Novel Dominantly Segregating PSMB10 Splice-Site Variant in Familial Autoinflammatory Disease with Immunoproteasome and Interferon-Related Dysregulation.Genes (Basel)202642792891PubTator, text miningPubMed
Type I and II Interferon Signalling Characterizes the Transcriptional Landscape of Sweet Syndrome.Exp Dermatol202642410891PubTator, text miningPubMed
From polyamine metabolism genes to immunoproteasome subunits: a transcriptome-based screening of candidate biomarkers in Crohn's disease.Sci Rep202642401658PubTator, text miningPubMed
Pan-cancer analysis identifies immunoproteasome as the predominant survival-associated component of antigen processing machinery.Transl Oncol202642364494PubTator, text miningPubMed
Functional characterization of EcPSMB10: Suppression of RGNNV replication via inhibiting autophagy in vitro.Fish Shellfish Immunol202642229675PubTator, text miningPubMed
Identification of Polyamine Metabolism-Related Biomarkers in Psoriasis: A Study Based on Transcriptomics and Single-Cell Sequencing.Exp Dermatol202642223029PubTator, text miningPubMed
NSCLC brain metastases exhibit reduced HLA-I antigen presentation machinery and immune evasion independent of IFNγ signaling defects.Mol Cancer202642210261PubTator, text miningPubMed
Novel de novo dominant PSMB10 variants in three patients with immune deficiency and liver disease.J Hum Immun202642170594PubTator, text miningPubMed
Monoallelic PSMB8 variants cause PRAAS with immunodeficiency through impaired immunoproteasome assembly.Am J Hum Genet202642167218PubTator, text miningPubMed

1 to 10 of 1,534

See all 1,534 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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