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Gene · 57007

ACKR3: atypical chemokine receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACKR3: atypical chemokine receptor 3. Genes, record 57007. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57007

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Gene

Symbol
ACKR3
HGNC
Name
atypical chemokine receptor 3
HGNC
NCBI Gene ID
57007
NCBI Gene
HGNC ID
HGNC:23692
HGNC
Ensembl
ENSG00000144476
NCBI Gene
Aliases
CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25106Atypical chemokine receptor 336214Ensembl, GeneID, HGNC

Source UniProt

Patents117

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1034P25106Espacenet
JP 2026504180 A2026-02-034P25106Espacenet
JP 2026504180 A2026-02-035P25106Espacenet
EP 4680730 A22026-01-2121P25106Espacenet
JP 2026004568 A2026-01-1441102P25106Espacenet
EP 4650780 A22025-11-192838P25106Espacenet
JP 2025147176 A2025-10-0616715P25106Espacenet
JP 2025529142 A2025-09-04234P25106Espacenet
US 12371689 B22025-07-29234P25106Espacenet
JP 2025522558 A2025-07-15244P25106Espacenet

1 to 10 of 117

See all 117 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,255

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACKR3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30CA006973Regional Oncology Research Center92025
P30CA008748Cancer Center Support Grant92025
R37AI058072Structural Basis for Chemokine Function92025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202882025
R01AI161880It's a tug of war: structure, consequences, and inhibition of CXCR4 and ACKR3 responses to lymphocyte chemoattractant CXCL1282025
UL1TR001863Yale Clinical and Translational Science Award72025
P30CA016058Cancer Center Support Grant62025
P30CA016086Cancer Center Support Grant62025
P30CA068485Cancer Center Support Grant62025

1 to 10 of 2,255Source NIH's project files

See all 2,255 nih grants

Papers3,960

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The CXCL12γ/ACKR3 Axis Is a Critical Determinant of Myocardial Angiogenesis and Functional Recovery After Infarction.JACC Basic Transl Sci202642804830PubTator, text miningPubMed
Combined detection of CXCR7 and CXCL12 for diagnosing acute myocardial infarction and predicting post-percutaneous coronary intervention major adverse cardiovascular events.J Med Biochem202642781331PubTator, text miningPubMed
Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single-cell and bulk transcriptomic analysis.J Cell Commun Signal202642695089PubTator, text miningPubMed
Proadrenomedullin N-Terminal 20 Peptide (PAMP) Increases Proliferation and Induces Cytoskeleton Remodeling in Melanoma Cells Through the CXCR7/CXCR4/β-Arrestin Axis.Molecules202642653874PubTator, text miningPubMed
Single-cell transcriptomics reveals a correlation between inflammatory C7 fibroblasts in cervical tumor-adjacent normal tissues and cervical cancer progression.Front Cell Dev Biol202642638795PubTator, text miningPubMed
CXCL12/CXCR4 signaling governs ischemic neurovascular pathophysiology and repair: a multidimensional contextual analysis.Angiogenesis202642625089PubTator, text miningPubMed
KLF4 in Smooth Muscle Cell-Derived Progenitor Cells Is Essential for Angiotensin II-Induced Cardiac Inflammation and Fibrosis.Arterioscler Thromb Vasc Biol202642619593PubTator, text miningPubMed
Identification of Entacapone as a Novel β-Arrestin 1 Biased Antagonist of CXCR7.Molecules202642588455PubTator, text miningPubMed
Age- and sex-related differences in physiological rotation patterns of the cervical spine: A detailed upright multidetector CT analysis.J Orthop Sci202642570901PubTator, text miningPubMed
Comprehensive In Silico Analysis of the CXCL12, C55Y Mutation Reveals Structural and Functional Disruption in CXCR4/CXCR7 Signaling.Evol Bioinform Online202642564356PubTator, text miningPubMed

1 to 10 of 3,960

See all 3,960 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57007

GET https://conductscience.org/api/genes/v1/57007/patents?page=2