Gene · 57016
AKR1B10: aldo-keto reductase family 1 member B10
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AKR1B10: aldo-keto reductase family 1 member B10. Genes, record 57016. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57016
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O60218 | Aldo-keto reductase family 1 member B10 | 316 | 20 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025081326 A | 2025-05-27 | 34 | O60218 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3961 | O60218 | Espacenet |
| JP 2023049296 A | 2023-04-10 | 25 | O60218 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5984 | O60218 | Espacenet |
| JP 2022141755 A | 2022-09-29 | 528 | O60218 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 3961 | O60218 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 106932 | O60218 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 407 | O60218 | Espacenet |
| US 11066709 B2 | 2021-07-20 | 34 | O60218 | Espacenet |
| KR 1020210075929 A | 2021-06-23 | 13 | O60218 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,041
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AKR1B10 papers | Newest fiscal year |
|---|---|---|---|
| P30ES013508 | Center of Excellence in Environmental Toxicology | 18 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 8 | 2025 |
| P30DK050306 | Center for Molecular Studies in Digestive and Liver Diseases | 8 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 5 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 4 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 3 | 2025 |
| P42ES004940 | The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation | 3 | 2025 |
1 to 10 of 1,041Source NIH's project files
See all 1,041 nih grantsPapers1,760
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis. | Adv Sci (Weinh) | 2026 | 42811488 | PubTator, text mining | PubMed |
| Exploring the Therapeutic Effects of Artemisia rupestris L. Extract on Metabolic Dysfunction-Associated Fatty Liver Disease: Network Pharmacology and In Vitro Experiments. | Pharmaceuticals (Basel) | 2026 | 42797386 | PubTator, text mining | PubMed |
| The HARP (Hemoglobin-Albumin-C-Reactive Protein) Index: A Biologically Designed Composite Biomarker for Continuous Prognostic Modeling in Locally Advanced Nasopharyngeal Carcinoma. | Diseases | 2026 | 42783199 | PubTator, text mining | PubMed |
| Comment on "AKR1B10 Drives Lenvatinib Resistance in Hepatocellular Carcinoma by Suppressing Ferroptosis via NQO1/GPX4 Axis". | J Gastroenterol Hepatol | 2026 | 42745283 | PubTator, text mining | PubMed |
| Integrative single-cell and genomic analysis reveals NMB as a driver of metastatic adaptation in esophageal squamous cell carcinoma via metabolic rewiring and immune evasion. | Front Cell Dev Biol | 2026 | 42740929 | PubTator, text mining | PubMed |
| Aldo-Keto Reductase 1B10 (AKR1B10) Restrains Trophoblast Cell Invasion via the ERK Signaling Pathway. | Int J Mol Sci | 2026 | 42737624 | PubTator, text mining | PubMed |
| AKR1B1 and AKR1B10 as Potential Prognostic Biomarkers of Endometrial Cancer. | Int J Mol Sci | 2026 | 42737538 | PubTator, text mining | PubMed |
| 4-Hydroxytamoxifen induces a noncanonical ferroptosis in lung adenocarcinoma by targeting AKR1B10. | Clin Transl Med | 2026 | 42707018 | PubTator, text mining | PubMed |
| Hepatitis Viruses Infection Up-Regulating Fibrosis Signals in Hepatocellular Carcinoma. | Biomedicines | 2026 | 42652100 | PubTator, text mining | PubMed |
| AKR1B10 Drives Lenvatinib Resistance in Hepatocellular Carcinoma by Suppressing Ferroptosis via NQO1/GPX4 Axis. | J Gastroenterol Hepatol | 2026 | 42605041 | PubTator, text mining | PubMed |
1 to 10 of 1,760
See all 1,760 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/57016
GET https://conductscience.org/api/genes/v1/57016/patents?page=2