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Gene · 57016

AKR1B10: aldo-keto reductase family 1 member B10

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AKR1B10: aldo-keto reductase family 1 member B10. Genes, record 57016. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57016

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Gene

Symbol
AKR1B10
HGNC
Name
aldo-keto reductase family 1 member B10
HGNC
NCBI Gene ID
57016
NCBI Gene
HGNC ID
HGNC:382
HGNC
Ensembl
ENSG00000198074
NCBI Gene
Aliases
AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60218Aldo-keto reductase family 1 member B1031620Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025081326 A2025-05-2734O60218Espacenet
JP 2025062604 A2025-04-143961O60218Espacenet
JP 2023049296 A2023-04-1025O60218Espacenet
US 11564998 B22023-01-315984O60218Espacenet
JP 2022141755 A2022-09-29528O60218Espacenet
US 11446398 B22022-09-203961O60218Espacenet
JP 2022524081 A2022-04-27106932O60218Espacenet
US 11078247 B22021-08-03407O60218Espacenet
US 11066709 B22021-07-2034O60218Espacenet
KR 1020210075929 A2021-06-2313O60218Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,041

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAKR1B10 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology182025
P30CA016520Abramson Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant82025
P30DK019525University of Pennsylvania Diabetes Research Center82025
P30DK050306Center for Molecular Studies in Digestive and Liver Diseases82025
P30CA068485Cancer Center Support Grant62025
P30ES006694Southwest Environmental Health Sciences Center52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025
P42ES004940The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation32025

1 to 10 of 1,041Source NIH's project files

See all 1,041 nih grants

Papers1,760

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis.Adv Sci (Weinh)202642811488PubTator, text miningPubMed
Exploring the Therapeutic Effects of Artemisia rupestris L. Extract on Metabolic Dysfunction-Associated Fatty Liver Disease: Network Pharmacology and In Vitro Experiments.Pharmaceuticals (Basel)202642797386PubTator, text miningPubMed
The HARP (Hemoglobin-Albumin-C-Reactive Protein) Index: A Biologically Designed Composite Biomarker for Continuous Prognostic Modeling in Locally Advanced Nasopharyngeal Carcinoma.Diseases202642783199PubTator, text miningPubMed
Comment on "AKR1B10 Drives Lenvatinib Resistance in Hepatocellular Carcinoma by Suppressing Ferroptosis via NQO1/GPX4 Axis".J Gastroenterol Hepatol202642745283PubTator, text miningPubMed
Integrative single-cell and genomic analysis reveals NMB as a driver of metastatic adaptation in esophageal squamous cell carcinoma via metabolic rewiring and immune evasion.Front Cell Dev Biol202642740929PubTator, text miningPubMed
Aldo-Keto Reductase 1B10 (AKR1B10) Restrains Trophoblast Cell Invasion via the ERK Signaling Pathway.Int J Mol Sci202642737624PubTator, text miningPubMed
AKR1B1 and AKR1B10 as Potential Prognostic Biomarkers of Endometrial Cancer.Int J Mol Sci202642737538PubTator, text miningPubMed
4-Hydroxytamoxifen induces a noncanonical ferroptosis in lung adenocarcinoma by targeting AKR1B10.Clin Transl Med202642707018PubTator, text miningPubMed
Hepatitis Viruses Infection Up-Regulating Fibrosis Signals in Hepatocellular Carcinoma.Biomedicines202642652100PubTator, text miningPubMed
AKR1B10 Drives Lenvatinib Resistance in Hepatocellular Carcinoma by Suppressing Ferroptosis via NQO1/GPX4 Axis.J Gastroenterol Hepatol202642605041PubTator, text miningPubMed

1 to 10 of 1,760

See all 1,760 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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