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Gene · 5710

PSMD4: proteasome 26S subunit ubiquitin receptor, non-ATPase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PSMD4: proteasome 26S subunit ubiquitin receptor, non-ATPase 4. Genes, record 5710. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5710

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Gene

Symbol
PSMD4
HGNC
Name
proteasome 26S subunit ubiquitin receptor, non-ATPase 4
HGNC
NCBI Gene ID
5710
NCBI Gene
HGNC ID
HGNC:9561
HGNC
Ensembl
ENSG00000159352
NCBI Gene
Aliases
AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P5503626S proteasome non-ATPase regulatory subunit 4377133Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-198525P55036Espacenet
JP 2025517970 A2025-06-128525P55036Espacenet
JP 2025038035 A2025-03-184458P55036Espacenet
US 12134655 B22024-11-054458P55036Espacenet
US 11694765 B22023-07-04302P55036Espacenet
US 11564998 B22023-01-316198P55036Espacenet
US 11446398 B22022-09-2067776P55036Espacenet
JP 2022534270 A2022-07-2831P55036Espacenet
JP 2022530667 A2022-06-304458P55036Espacenet
JP 2022524081 A2022-04-27170747P55036Espacenet

1 to 10 of 60

See all 60 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BORTEZOMIBCHEMBL32504126S proteasome inhibitorINHIBITORChEMBL
BORTEZOMIB D-MANNITOLCHEMBL531512226S proteasome inhibitorINHIBITORChEMBL
CARFILZOMIBCHEMBL45188726S proteasome inhibitorINHIBITORChEMBL
IXAZOMIBCHEMBL214129626S proteasome inhibitorINHIBITORChEMBL
IXAZOMIB CITRATECHEMBL354543226S proteasome inhibitorINHIBITORChEMBL
OPROZOMIBCHEMBL210388426S proteasome inhibitorINHIBITORChEMBL

Trials1,229

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416CARFILZOMIBPHASE2ClinicalTrials.gov
NCT07601100BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07600151BORTEZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07513129BORTEZOMIBPHASE1ClinicalTrials.gov
NCT07479979CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07464210BORTEZOMIBPHASE2ClinicalTrials.gov
NCT07463807CARFILZOMIBPHASE1/PHASE2ClinicalTrials.gov
NCT07428369BORTEZOMIBPHASE2/PHASE3ClinicalTrials.gov
NCT07391657BORTEZOMIBPHASE3ClinicalTrials.gov
NCT07391657CARFILZOMIBPHASE3ClinicalTrials.gov

1 to 10 of 1,229

See all 1,229 trials

NIH grants954

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePSMD4 papersNewest fiscal year
ZIABC011490Maintaining cell health by targeted protein degradation172025
R01GM065334Solution structure and dynamics of polyubiquitin chains142025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control62025
P30CA016672Cancer Center Support Grant52025
P30CA006973Regional Oncology Research Center32025
P30CA008748Cancer Center Support Grant32025
P30CA016086Cancer Center Support Grant32025
P30CA016087Cancer Center Support Grant32025
P30GM124165NE-CAT: A Resource for Advanced Macromolecular Crystallography32025
P50CA098252SPORE in Cervical Cancer32025

1 to 10 of 954Source NIH's project files

See all 954 nih grants

Papers1,432

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A multi-region transcriptomic framework reveals global and region-specific ubiquitin-proteasome system biomarkers in Alzheimer's disease.Funct Integr Genomics202642809130PubTator, text miningPubMed
Functional Engineered Exosomes Loaded with Nanoenzymes Targeting the Proteasome and Inflammation for the Treatment of Rheumatoid Arthritis.Small202642522687PubTator, text miningPubMed
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryo-electron microscopy.Mol Cell202642476128PubTator, text miningPubMed
Methylated SNHG3 lncRNA counteracts PSMD4-inhibited angiogenesis by HnRNPA2B1 SUMOylation in peripheral arterial disease.Biochem Pharmacol202642398870PubTator, text miningPubMed
PSMD4 promotes malignant phenotypes and is associated with angiogenesis-related signaling and immune remodeling in hepatocellular carcinoma.Discov Oncol202642262718PubTator, text miningPubMed
Implication of Epigenetic Alterations of ZEB1 in Colorectal Cancer (CRC) Pathogenesis and Therapy Development.Curr Issues Mol Biol202641899428PubTator, text miningPubMed
The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding.Sci Adv202641790892PubTator, text miningPubMed
Physiological and molecular dynamic changes during 23-day high-altitude exposure reveal novel biomarkers for acclimatization.Front Physiol202641788875PubTator, text miningPubMed
The lactate/PSMD4/glycolysis feedback loop drives chemoresistance and immunosuppression in gallbladder cancer.Sci Bull (Beijing)202641786576PubTator, text miningPubMed
SNRPD2-dependency Fuels an Oncogenic Alternative Splicing Repertoire Driving Disease Aggressiveness in Glioma.Cancer Genomics Proteomics202641771572PubTator, text miningPubMed

1 to 10 of 1,432

See all 1,432 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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