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PNPLA2: patatin like domain 2, triacylglycerol lipase
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Gene · 57104

Papers3,807

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 3,807

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TitleJournalYearPMIDFound bySource
The Role of HILPDA in Diseases: Mechanisms and Functional Insights.J Lipid Res202642810643PubTator, text miningPubMed
Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features.Cancers (Basel)202642794967PubTator, text miningPubMed
ACOX1 downregulation contributes to macrophage M1 polarization and neutrophilic airway inflammation in asthma.Int Immunopharmacol202642772039PubTator, text miningPubMed
Delving into the clinical and genetic spectrum of NLSDM: A case study.J Neuromuscul Dis202642765452PubTator, text miningPubMed
Bovine viral diarrhea virus (BVDV) relies on cellular lipid droplet biogenesis and lipolysis to provide energy for viral replication.Vet Res202642763408PubTator, text miningPubMed
Defensive lipid droplets are PUFA reservoirs and suppliers driving bacterial clearance and inflammation.Cell Rep202642747966PubTator, text miningPubMed
Lipidomic Remodeling by HILPDA in Granulosa Cells Impairs Ovarian Reserve Through Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis.FASEB J202642725586PubTator, text miningPubMed
From physiological homeostasis to pathological injury: Cell-specific functions, imbalance mechanisms, and disease biomarker value of brain lipid droplets.Int Immunopharmacol202642721506PubTator, text miningPubMed
Androgen-Driven Dysregulation of Lipolysis in Cumulus Cells: Molecular Evidence and Metabolic Implications in Polycystic Ovary Syndrome.Reprod Med Biol202642682701PubTator, text miningPubMed
Liquiritigenin Ameliorates High-Fat Diet-Induced Hepatic Steatosis by Promoting Lipid Droplet Catabolism via PLIN2-ATGL Regulation.Phytother Res202642675379PubTator, text miningPubMed
Recent advances in adult-onset disorders of muscle lipid metabolism.Curr Opin Neurol202642656071PubTator, text miningPubMed
Expression and positive impact of omentin-1 on in vitro porcine oocyte maturation via the ERK1/2 and PRKAA1.Reproduction202642640570PubTator, text miningPubMed
DABPU-DE targeting host adipose triglyceride lipase provides broad-spectrum anti-coronavirus effects in vitro.Front Pharmacol202642602407PubTator, text miningPubMed
In vitro Modeling of Adipogenesis Using Mesenchymal Stem Cells from Subcutaneous Adipose Tissue to Explore the Cellular and Molecular Mechanisms Underlying Pediatric Obesity and Obesogenic Memory.Obes Facts202642599843PubTator, text miningPubMed
HILPDA Repression Induces Methuosis in Breast and Liver Cancer Cells by Dysregulating Lipid Metabolism.Biofactors202642595722PubTator, text miningPubMed
Substrate-Selective Lipolysis Facilitates Unsaturated TAG Accumulation in Obesity.Diabetes202642579480PubTator, text miningPubMed
Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis.Cell Res202642533097PubTator, text miningPubMed
Adipose triglyceride lipase driven lipolysis as a targetable metabolic vulnerability in prostate cancer with intrinsic metabolic inflexibility.Br J Cancer202642493599PubTator, text miningPubMed
Mechanistic insights into the role of PEDF-R (PNPLA2) in photoreceptors.Biosci Rep202642423603PubTator, text miningPubMed
PLIN1 restoration modulates lipid reprogramming and impedes tumor growth in ovarian cancer.BMC Cancer202642414938PubTator, text miningPubMed

gene-search-2026-11-11-0.2.0

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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