ConductScience.org, home

Gene · 57104

PNPLA2: patatin like domain 2, triacylglycerol lipase

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. PNPLA2: patatin like domain 2, triacylglycerol lipase. Genes, record 57104. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57104

On this page

Gene

Symbol
PNPLA2
HGNC
Name
patatin like domain 2, triacylglycerol lipase
HGNC
NCBI Gene ID
57104
NCBI Gene
HGNC ID
HGNC:30802
HGNC
Ensembl
ENSG00000177666
NCBI Gene
Aliases
1110001C14Rik, ATGL, FP17548, PEDF-R, TTS-2.2, TTS2, desnutrin, iPLA2zeta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96AD5Patatin-like phospholipase domain-containing protein 25040Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457146Q96AD5Espacenet
EP 4650780 A22025-11-196301Q96AD5Espacenet
JP 2025517970 A2025-06-126301Q96AD5Espacenet
US 11446398 B22022-09-2061417Q96AD5Espacenet
JP 2022538497 A2022-09-02145Q96AD5Espacenet
US 11400116 B22022-08-024638Q96AD5Espacenet
KR 1020220069917 A2022-05-27125Q96AD5Espacenet
JP 2022524081 A2022-04-27164388Q96AD5Espacenet
US 11078247 B22021-08-038677Q96AD5Espacenet
US 10987431 B22021-04-278Q96AD5Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,107

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePNPLA2 papersNewest fiscal year
P30DK020572Michigan Diabetes Research Center (MDRC)252025
ZIAEY000306Role of Protein Interactions in Retina Development and Function212025
R01DK076629Analysis of Lipolytic Trafficking in Adipocytes.182025
P30DK056341Washington University Nutrition Obesity Research Center162025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)112025
P30DK020579Diabetes Research Center112025
R01DK062292Analysis of Cellular Plasticity in White Adipose Tissue.112025
P30DK045735Yale Diabetes Research Center102025
P30DK089503Michigan Nutrition Obesity Research Center82025
R01AA020735Altered Lipid Droplet Trafficking: Role in Alcoholic Fatty Liver Disease82025

1 to 10 of 2,107Source NIH's project files

See all 2,107 nih grants

Papers3,807

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Role of HILPDA in Diseases: Mechanisms and Functional Insights.J Lipid Res202642810643PubTator, text miningPubMed
Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features.Cancers (Basel)202642794967PubTator, text miningPubMed
ACOX1 downregulation contributes to macrophage M1 polarization and neutrophilic airway inflammation in asthma.Int Immunopharmacol202642772039PubTator, text miningPubMed
Delving into the clinical and genetic spectrum of NLSDM: A case study.J Neuromuscul Dis202642765452PubTator, text miningPubMed
Bovine viral diarrhea virus (BVDV) relies on cellular lipid droplet biogenesis and lipolysis to provide energy for viral replication.Vet Res202642763408PubTator, text miningPubMed
Defensive lipid droplets are PUFA reservoirs and suppliers driving bacterial clearance and inflammation.Cell Rep202642747966PubTator, text miningPubMed
Lipidomic Remodeling by HILPDA in Granulosa Cells Impairs Ovarian Reserve Through Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis.FASEB J202642725586PubTator, text miningPubMed
From physiological homeostasis to pathological injury: Cell-specific functions, imbalance mechanisms, and disease biomarker value of brain lipid droplets.Int Immunopharmacol202642721506PubTator, text miningPubMed
Androgen-Driven Dysregulation of Lipolysis in Cumulus Cells: Molecular Evidence and Metabolic Implications in Polycystic Ovary Syndrome.Reprod Med Biol202642682701PubTator, text miningPubMed
Liquiritigenin Ameliorates High-Fat Diet-Induced Hepatic Steatosis by Promoting Lipid Droplet Catabolism via PLIN2-ATGL Regulation.Phytother Res202642675379PubTator, text miningPubMed

1 to 10 of 3,807

See all 3,807 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57104

GET https://conductscience.org/api/genes/v1/57104/patents?page=2