Gene · 57104
PNPLA2: patatin like domain 2, triacylglycerol lipase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PNPLA2: patatin like domain 2, triacylglycerol lipase. Genes, record 57104. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57104
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96AD5 | Patatin-like phospholipase domain-containing protein 2 | 504 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 57146 | Q96AD5 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6301 | Q96AD5 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6301 | Q96AD5 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 61417 | Q96AD5 | Espacenet |
| JP 2022538497 A | 2022-09-02 | 145 | Q96AD5 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 4638 | Q96AD5 | Espacenet |
| KR 1020220069917 A | 2022-05-27 | 125 | Q96AD5 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 164388 | Q96AD5 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8677 | Q96AD5 | Espacenet |
| US 10987431 B2 | 2021-04-27 | 8 | Q96AD5 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,107
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PNPLA2 papers | Newest fiscal year |
|---|---|---|---|
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 25 | 2025 |
| ZIAEY000306 | Role of Protein Interactions in Retina Development and Function | 21 | 2025 |
| R01DK076629 | Analysis of Lipolytic Trafficking in Adipocytes. | 18 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 16 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 11 | 2025 |
| P30DK020579 | Diabetes Research Center | 11 | 2025 |
| R01DK062292 | Analysis of Cellular Plasticity in White Adipose Tissue. | 11 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 10 | 2025 |
| P30DK089503 | Michigan Nutrition Obesity Research Center | 8 | 2025 |
| R01AA020735 | Altered Lipid Droplet Trafficking: Role in Alcoholic Fatty Liver Disease | 8 | 2025 |
1 to 10 of 2,107Source NIH's project files
See all 2,107 nih grantsPapers3,807
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The Role of HILPDA in Diseases: Mechanisms and Functional Insights. | J Lipid Res | 2026 | 42810643 | PubTator, text mining | PubMed |
| Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features. | Cancers (Basel) | 2026 | 42794967 | PubTator, text mining | PubMed |
| ACOX1 downregulation contributes to macrophage M1 polarization and neutrophilic airway inflammation in asthma. | Int Immunopharmacol | 2026 | 42772039 | PubTator, text mining | PubMed |
| Delving into the clinical and genetic spectrum of NLSDM: A case study. | J Neuromuscul Dis | 2026 | 42765452 | PubTator, text mining | PubMed |
| Bovine viral diarrhea virus (BVDV) relies on cellular lipid droplet biogenesis and lipolysis to provide energy for viral replication. | Vet Res | 2026 | 42763408 | PubTator, text mining | PubMed |
| Defensive lipid droplets are PUFA reservoirs and suppliers driving bacterial clearance and inflammation. | Cell Rep | 2026 | 42747966 | PubTator, text mining | PubMed |
| Lipidomic Remodeling by HILPDA in Granulosa Cells Impairs Ovarian Reserve Through Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis. | FASEB J | 2026 | 42725586 | PubTator, text mining | PubMed |
| From physiological homeostasis to pathological injury: Cell-specific functions, imbalance mechanisms, and disease biomarker value of brain lipid droplets. | Int Immunopharmacol | 2026 | 42721506 | PubTator, text mining | PubMed |
| Androgen-Driven Dysregulation of Lipolysis in Cumulus Cells: Molecular Evidence and Metabolic Implications in Polycystic Ovary Syndrome. | Reprod Med Biol | 2026 | 42682701 | PubTator, text mining | PubMed |
| Liquiritigenin Ameliorates High-Fat Diet-Induced Hepatic Steatosis by Promoting Lipid Droplet Catabolism via PLIN2-ATGL Regulation. | Phytother Res | 2026 | 42675379 | PubTator, text mining | PubMed |
1 to 10 of 3,807
See all 3,807 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/57104
GET https://conductscience.org/api/genes/v1/57104/patents?page=2