Gene · 57142
RTN4: reticulon 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RTN4: reticulon 4. Genes, record 57142. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57142
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NQC3 | Reticulon-4 | 1,192 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents65
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 61438 | Q9NQC3 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6068 | Q9NQC3 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3793 | Q9NQC3 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3793 | Q9NQC3 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6068 | Q9NQC3 | Espacenet |
| US 12156890 B2 | 2024-12-03 | 27 | Q9NQC3 | Espacenet |
| US 12156890 B2 | 2024-12-03 | 43 | Q9NQC3 | Espacenet |
| US 11654161 B2 | 2023-05-23 | 27 | Q9NQC3 | Espacenet |
| US 11654161 B2 | 2023-05-23 | 43 | Q9NQC3 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 72791 | Q9NQC3 | Espacenet |
1 to 10 of 65
See all 65 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials5
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT01753076 | OZANEZUMAB | PHASE2 | 2017-04-19 | ClinicalTrials.gov |
| NCT01435993 | OZANEZUMAB | PHASE1 | ClinicalTrials.gov | |
| NCT01424423 | OZANEZUMAB | PHASE1 | ClinicalTrials.gov | |
| NCT00875446 | OZANEZUMAB | PHASE1 | ClinicalTrials.gov | |
| NCT00406016 | ATINUMAB | PHASE1 | ClinicalTrials.gov |
NIH grants1,616
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RTN4 papers | Newest fiscal year |
|---|---|---|---|
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| P30DK034989 | Yale Liver Center | 5 | 2025 |
| P01AI063302 | The intersection of innate and adaptive immunity to intracellular pathogens | 4 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
| U19AI135990 | HPMI: Host Pathogen Mapping Initiative | 4 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 3 | 2025 |
| P30EY014801 | Miami Center for Vision Research | 3 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 3 | 2025 |
1 to 10 of 1,616Source NIH's project files
See all 1,616 nih grantsPapers2,668
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrative Transcriptomic Analysis and Single-Cell Characterization Identify RTN4 as a Candidate PBMC-Derived Hub Gene Associated with COPD and Coronary Artery Disease. | Genes (Basel) | 2026 | 42792939 | PubTator, text mining | PubMed |
| Lost in translation: why pharmacological trials keep failing in acute spinal cord injury. | Arq Neuropsiquiatr | 2026 | 42595311 | PubTator, text mining | PubMed |
| The Integrated Neurological Change Score Is a Sensitive Neurological Composite Measure to Evaluate Cervical Spinal Cord Injury Trials. | J Neurotrauma | 2026 | 42421461 | PubTator, text mining | PubMed |
| Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression. | Adv Sci (Weinh) | 2026 | 42325213 | PubTator, text mining | PubMed |
| Neural stem cell-derived extracellular vesicles drive early neuroprotective and anti-apoptotic responses in spinal cord injury organotypic slices. | Front Cell Neurosci | 2026 | 42317583 | PubTator, text mining | PubMed |
| From Molecules to Biomarkers: Nogo Proteins and Receptors in the Early Detection of Type 2 Diabetes Complications: A Systematic Review. | Int J Mol Sci | 2026 | 42278646 | PubTator, text mining | PubMed |
| An integrated nano-delivery platform via baicalein-loaded polydopamine-MOF for enhanced neuroprotection against retinal ischemia reperfusion injury. | Mater Today Bio | 2026 | 42256062 | PubTator, text mining | PubMed |
| Nogo-B attenuates vascular calcification by activating NRF2-SLC7A11 to enhance antioxidant defense. | Redox Biol | 2026 | 42176502 | PubTator, text mining | PubMed |
| Decoding Pathogenic Mutational Landscapes in Alzheimer's Disease Through Integrated Transcriptomics. | Hum Mutat | 2026 | 42131724 | PubTator, text mining | PubMed |
| Comprehensive Analysis of Core Genes, Key Pathways, and Immune Infiltration in Intervertebral Disc Degeneration Using Machine Learning and Experimental Validation. | Iran J Allergy Asthma Immunol | 2026 | 42130144 | PubTator, text mining | PubMed |
1 to 10 of 2,668
See all 2,668 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/57142
GET https://conductscience.org/api/genes/v1/57142/patents?page=2