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Gene · 57142

RTN4: reticulon 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RTN4: reticulon 4. Genes, record 57142. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57142

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Gene

Symbol
RTN4
HGNC
Name
reticulon 4
HGNC
NCBI Gene ID
57142
NCBI Gene
HGNC ID
HGNC:14085
HGNC
Ensembl
ENSG00000115310
NCBI Gene
Aliases
ASY, KIAA0886, NI220/250, NOGO, NOGOA, NOGOB, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NQC3Reticulon-41,1922Ensembl, GeneID, HGNC

Source UniProt

Patents65

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461438Q9NQC3Espacenet
EP 4641201 A22025-10-296068Q9NQC3Espacenet
JP 2025529142 A2025-09-043793Q9NQC3Espacenet
US 12371689 B22025-07-293793Q9NQC3Espacenet
JP 2025517969 A2025-06-126068Q9NQC3Espacenet
US 12156890 B22024-12-0327Q9NQC3Espacenet
US 12156890 B22024-12-0343Q9NQC3Espacenet
US 11654161 B22023-05-2327Q9NQC3Espacenet
US 11654161 B22023-05-2343Q9NQC3Espacenet
US 11446398 B22022-09-2072791Q9NQC3Espacenet

1 to 10 of 65

See all 65 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATINUMABCHEMBL1742987Reticulon-4 inhibitorINHIBITORChEMBL
OZANEZUMABCHEMBL2108679Reticulon-4 inhibitorINHIBITORChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01753076OZANEZUMABPHASE22017-04-19ClinicalTrials.gov
NCT01435993OZANEZUMABPHASE1ClinicalTrials.gov
NCT01424423OZANEZUMABPHASE1ClinicalTrials.gov
NCT00875446OZANEZUMABPHASE1ClinicalTrials.gov
NCT00406016ATINUMABPHASE1ClinicalTrials.gov

NIH grants1,616

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRTN4 papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award62025
P30DK034989Yale Liver Center52025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens42025
P30CA014195Cancer Center Support Grant (CCSG)42025
P30CA016672Cancer Center Support Grant42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
U19AI135990HPMI: Host Pathogen Mapping Initiative42025
P30DK045735Yale Diabetes Research Center32025
P30EY014801Miami Center for Vision Research32025
P40OD010440Caenorhabditis Genetics Center32025

1 to 10 of 1,616Source NIH's project files

See all 1,616 nih grants

Papers2,668

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative Transcriptomic Analysis and Single-Cell Characterization Identify RTN4 as a Candidate PBMC-Derived Hub Gene Associated with COPD and Coronary Artery Disease.Genes (Basel)202642792939PubTator, text miningPubMed
Lost in translation: why pharmacological trials keep failing in acute spinal cord injury.Arq Neuropsiquiatr202642595311PubTator, text miningPubMed
The Integrated Neurological Change Score Is a Sensitive Neurological Composite Measure to Evaluate Cervical Spinal Cord Injury Trials.J Neurotrauma202642421461PubTator, text miningPubMed
Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression.Adv Sci (Weinh)202642325213PubTator, text miningPubMed
Neural stem cell-derived extracellular vesicles drive early neuroprotective and anti-apoptotic responses in spinal cord injury organotypic slices.Front Cell Neurosci202642317583PubTator, text miningPubMed
From Molecules to Biomarkers: Nogo Proteins and Receptors in the Early Detection of Type 2 Diabetes Complications: A Systematic Review.Int J Mol Sci202642278646PubTator, text miningPubMed
An integrated nano-delivery platform via baicalein-loaded polydopamine-MOF for enhanced neuroprotection against retinal ischemia reperfusion injury.Mater Today Bio202642256062PubTator, text miningPubMed
Nogo-B attenuates vascular calcification by activating NRF2-SLC7A11 to enhance antioxidant defense.Redox Biol202642176502PubTator, text miningPubMed
Decoding Pathogenic Mutational Landscapes in Alzheimer's Disease Through Integrated Transcriptomics.Hum Mutat202642131724PubTator, text miningPubMed
Comprehensive Analysis of Core Genes, Key Pathways, and Immune Infiltration in Intervertebral Disc Degeneration Using Machine Learning and Experimental Validation.Iran J Allergy Asthma Immunol202642130144PubTator, text miningPubMed

1 to 10 of 2,668

See all 2,668 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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