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Gene · 57154

SMURF1: SMAD specific E3 ubiquitin protein ligase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMURF1: SMAD specific E3 ubiquitin protein ligase 1. Genes, record 57154. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57154

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Gene

Symbol
SMURF1
HGNC
Name
SMAD specific E3 ubiquitin protein ligase 1
HGNC
NCBI Gene ID
57154
NCBI Gene
HGNC ID
HGNC:16807
HGNC
Ensembl
ENSG00000198742
NCBI Gene
Aliases
KIAA1625
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HCE7E3 ubiquitin-protein ligase SMURF17577Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463767Q9HCE7Espacenet
EP 4493157 A22025-01-2227Q9HCE7Espacenet
US 11827910 B22023-11-2810Q9HCE7Espacenet
JP 2023546156 A2023-11-0143Q9HCE7Espacenet
JP 2023545827 A2023-10-3141Q9HCE7Espacenet
JP 2023545831 A2023-10-3142Q9HCE7Espacenet
US 11730823 B22023-08-2210Q9HCE7Espacenet
JP 2023529740 A2023-07-1134Q9HCE7Espacenet
JP 2022550130 A2022-11-3041Q9HCE7Espacenet
US 11446398 B22022-09-2079705Q9HCE7Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,124

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMURF1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant62025
P30CA076292Moffitt Cancer Center Support Grant52025
ZIABC011168Physiological and pathological functions of E3 ubiquitin ligases Smurfs52025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025
P30DK017047Diabetes Research Center32025
ZIABC010419Molecular Mechanisms of TGF-beta Signaling Pathway32025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 522025
P30CA016359Cancer Center Support Grant22025
P30CA030199Cancer Center Support Grant (CCSG)22025

1 to 10 of 1,124Source NIH's project files

See all 1,124 nih grants

Papers1,908

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
AMOTL2 inhibits lymph node metastasis in gastric cancer by suppressing TGF-β/Smad signaling and is destabilized by the E3 ubiquitin ligase SMURF1.Int J Biol Sci202642695019PubTator, text miningPubMed
Paraspeckle-Mediated Integration of Nuclear RNA Regulation in Skeletal Homeostasis and Pathological Disorder.Calcif Tissue Int202642634043PubTator, text miningPubMed
ZNF143 suppresses mitophagy to drive MASLD progression by regulating SMURF1/TRPV1 axis.Mol Genet Genomics202642576075PubTator, text miningPubMed
Smoking-Related Clinical and Molecular Abnormalities in Idiopathic Pulmonary Fibrosis-Associated Pulmonary Hypertension.Pulm Circ202642454257PubTator, text miningPubMed
CLU delays fracture healing and intercepts osteogenic differentiation by enhancing SMURF1-mediated DDX5 ubiquitination.Biochem Pharmacol202642320699PubTator, text miningPubMed
Targeting WFS1 overcomes KRASG12D dependency and adaptive resistance to KRAS inhibition in pancreatic cancer.NPJ Precis Oncol202642298062PubTator, text miningPubMed
Ubiquitination of Smad2 by Smurf1 inhibits endothelial-to-mesenchymal transition in human coronary artery endothelial cells.Sci Rep202642265299PubTator, text miningPubMed
MCCC2 stabilizes LTBP1 via suppressing SMURF1-dependent ubiquitination to drive bone metastasis in prostate cancer.Oncogene202642251191PubTator, text miningPubMed
A Rras2-BMPR2 feedback loop sustains osteogenesis and represents a therapeutic target for osteoporosis.Nat Commun202642230599PubTator, text miningPubMed
PSMC5 Orchestrates an Immunosuppressive Niche and Metastasis in Colorectal Cancer via SMURF1-Mediated K11-Linked Ubiquitination of METTL14.Int J Biol Sci202642212325PubTator, text miningPubMed

1 to 10 of 1,908

See all 1,908 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57154

GET https://conductscience.org/api/genes/v1/57154/patents?page=2