Gene · 57154
SMURF1: SMAD specific E3 ubiquitin protein ligase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SMURF1: SMAD specific E3 ubiquitin protein ligase 1. Genes, record 57154. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57154
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9HCE7 | E3 ubiquitin-protein ligase SMURF1 | 757 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63767 | Q9HCE7 | Espacenet |
| EP 4493157 A2 | 2025-01-22 | 27 | Q9HCE7 | Espacenet |
| US 11827910 B2 | 2023-11-28 | 10 | Q9HCE7 | Espacenet |
| JP 2023546156 A | 2023-11-01 | 43 | Q9HCE7 | Espacenet |
| JP 2023545827 A | 2023-10-31 | 41 | Q9HCE7 | Espacenet |
| JP 2023545831 A | 2023-10-31 | 42 | Q9HCE7 | Espacenet |
| US 11730823 B2 | 2023-08-22 | 10 | Q9HCE7 | Espacenet |
| JP 2023529740 A | 2023-07-11 | 34 | Q9HCE7 | Espacenet |
| JP 2022550130 A | 2022-11-30 | 41 | Q9HCE7 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 79705 | Q9HCE7 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,124
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SMURF1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 5 | 2025 |
| ZIABC011168 | Physiological and pathological functions of E3 ubiquitin ligases Smurfs | 5 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 4 | 2025 |
| P30DK017047 | Diabetes Research Center | 3 | 2025 |
| ZIABC010419 | Molecular Mechanisms of TGF-beta Signaling Pathway | 3 | 2025 |
| P20GM103418 | Kansas IDeA Network of Biomedical Research Excellence 5 | 2 | 2025 |
| P30CA016359 | Cancer Center Support Grant | 2 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 2 | 2025 |
1 to 10 of 1,124Source NIH's project files
See all 1,124 nih grantsPapers1,908
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| AMOTL2 inhibits lymph node metastasis in gastric cancer by suppressing TGF-β/Smad signaling and is destabilized by the E3 ubiquitin ligase SMURF1. | Int J Biol Sci | 2026 | 42695019 | PubTator, text mining | PubMed |
| Paraspeckle-Mediated Integration of Nuclear RNA Regulation in Skeletal Homeostasis and Pathological Disorder. | Calcif Tissue Int | 2026 | 42634043 | PubTator, text mining | PubMed |
| ZNF143 suppresses mitophagy to drive MASLD progression by regulating SMURF1/TRPV1 axis. | Mol Genet Genomics | 2026 | 42576075 | PubTator, text mining | PubMed |
| Smoking-Related Clinical and Molecular Abnormalities in Idiopathic Pulmonary Fibrosis-Associated Pulmonary Hypertension. | Pulm Circ | 2026 | 42454257 | PubTator, text mining | PubMed |
| CLU delays fracture healing and intercepts osteogenic differentiation by enhancing SMURF1-mediated DDX5 ubiquitination. | Biochem Pharmacol | 2026 | 42320699 | PubTator, text mining | PubMed |
| Targeting WFS1 overcomes KRASG12D dependency and adaptive resistance to KRAS inhibition in pancreatic cancer. | NPJ Precis Oncol | 2026 | 42298062 | PubTator, text mining | PubMed |
| Ubiquitination of Smad2 by Smurf1 inhibits endothelial-to-mesenchymal transition in human coronary artery endothelial cells. | Sci Rep | 2026 | 42265299 | PubTator, text mining | PubMed |
| MCCC2 stabilizes LTBP1 via suppressing SMURF1-dependent ubiquitination to drive bone metastasis in prostate cancer. | Oncogene | 2026 | 42251191 | PubTator, text mining | PubMed |
| A Rras2-BMPR2 feedback loop sustains osteogenesis and represents a therapeutic target for osteoporosis. | Nat Commun | 2026 | 42230599 | PubTator, text mining | PubMed |
| PSMC5 Orchestrates an Immunosuppressive Niche and Metastasis in Colorectal Cancer via SMURF1-Mediated K11-Linked Ubiquitination of METTL14. | Int J Biol Sci | 2026 | 42212325 | PubTator, text mining | PubMed |
1 to 10 of 1,908
See all 1,908 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/57154
GET https://conductscience.org/api/genes/v1/57154/patents?page=2