ConductScience.org, home

Gene · 57192

MCOLN1: mucolipin TRP cation channel 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. MCOLN1: mucolipin TRP cation channel 1. Genes, record 57192. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57192

On this page

Gene

Symbol
MCOLN1
HGNC
Name
mucolipin TRP cation channel 1
HGNC
NCBI Gene ID
57192
NCBI Gene
HGNC ID
HGNC:13356
HGNC
Ensembl
ENSG00000090674
NCBI Gene
Aliases
LECD, MG-2, ML1, ML4, MLIV, MST080, MSTP080, TRP-ML1, TRPM-L1, TRPML1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9GZU1Mucolipin-158025Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21289Q9GZU1Espacenet
JP 2026004568 A2026-01-1454153Q9GZU1Espacenet
EP 4650780 A22025-11-192297Q9GZU1Espacenet
EP 4641201 A22025-10-291865Q9GZU1Espacenet
JP 2025529142 A2025-09-042578Q9GZU1Espacenet
JP 2025111747 A2025-07-30154Q9GZU1Espacenet
US 12371689 B22025-07-292578Q9GZU1Espacenet
JP 2025517969 A2025-06-121865Q9GZU1Espacenet
JP 2025517970 A2025-06-122297Q9GZU1Espacenet
JP 2025039642 A2025-03-2115Q9GZU1Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,001

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMCOLN1 papersNewest fiscal year
U54GM115458Great Plains IDeA-CTR132025
ZIAHL000140Lysosomal Diseases122025
R01GM088790Functional architecture of intracellular Ca2+ signals102025
ZIAHL006151Lysosome biogenesis and homeostasis82025
ZIADE000735Ca2+ signaling and HCO3- secretion by exocrine glands72025
ZIAHL006075Regulation of the Endo/Lysosomal pathway72025
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.42025
P30CA008748Cancer Center Support Grant42025
R01GM093290Regulation of the epithelial Ca2+ channels TRPV6 and TRPV542025
R35GM119412Directing Membrane Function with Inositol Lipids in Health and Disease42025

1 to 10 of 1,001Source NIH's project files

See all 1,001 nih grants

Papers1,559

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TRPML1 agonist ML-SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux.FEBS Open Bio202642781927PubTator, text miningPubMed
How to Perform a Tracer Displacement BRET Assay for the TRPML1 Ion Channel.Bio Protoc202642780723PubTator, text miningPubMed
TRPML1 loss disrupts lysosome-mitochondria homeostasis and sensitizes MDA-MB-231 triple-negative breast cancer cells to chemotherapy.J Biol Chem202642772563PubTator, text miningPubMed
IP3R2-mediated inter-organelle calcium signaling suppresses melanosome degradation.PLoS Biol202642640987PubTator, text miningPubMed
Photocatalytic Golgi Proteomics Reveals Palmitoylation-Regulated Golgiphagy.J Am Chem Soc202642619132PubTator, text miningPubMed
Bilateral Corneal Dystrophy Revealing Mucolipidosis Type IV: A Case Report.Cureus202642605403PubTator, text miningPubMed
Rare Heterozygous Loss-of-Function Variants in MCOLN1 Identified in Two Sporadic Patients with α-Synucleinopathies.Mov Disord202642557761PubTator, text miningPubMed
New insights on microglial lysosomal acidification: A therapeutic target of neurodegenerative diseases.Neurobiol Dis202642546981PubTator, text miningPubMed
Mechanistic insights into lysosomal stress response network in carcinogenesis and therapeutic opportunities.Biochim Biophys Acta Rev Cancer202642501904PubTator, text miningPubMed
A High-Loading Zn Single-Atom Nanozyme Targets the Zn/HIF-1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment.Adv Sci (Weinh)202642489277PubTator, text miningPubMed

1 to 10 of 1,559

See all 1,559 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57192

GET https://conductscience.org/api/genes/v1/57192/patents?page=2