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Gene · 5724

PTAFR: platelet activating factor receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTAFR: platelet activating factor receptor. Genes, record 5724. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5724

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Gene

Symbol
PTAFR
HGNC
Name
platelet activating factor receptor
HGNC
NCBI Gene ID
5724
NCBI Gene
HGNC ID
HGNC:9582
HGNC
Ensembl
ENSG00000169403
NCBI Gene
Aliases
PAFR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25105Platelet-activating factor receptor3423Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458137P25105Espacenet
JP 2026004568 A2026-01-1458138P25105Espacenet
JP 2026004568 A2026-01-1458139P25105Espacenet
JP 2025529142 A2025-09-043608P25105Espacenet
US 12371689 B22025-07-293608P25105Espacenet
US 11884978 B22024-01-30687P25105Espacenet
US 11446398 B22022-09-2063977P25105Espacenet
US 11446398 B22022-09-2063978P25105Espacenet
US 11446398 B22022-09-2063979P25105Espacenet
US 11400116 B22022-08-02340P25105Espacenet

1 to 10 of 45

See all 45 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
MINOPAFANTCHEMBL2104419Platelet activating factor receptor antagonistANTAGONISTChEMBL
MINOPAFANT IONCHEMBL2110618Platelet activating factor receptor antagonistANTAGONISTChEMBL
RUPATADINECHEMBL91397Platelet activating factor receptor antagonistANTAGONISTChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07064707RUPATADINEPHASE2ClinicalTrials.gov
NCT03770923RUPATADINEPHASE3ClinicalTrials.gov
NCT02358265RUPATADINEPHASE3ClinicalTrials.gov
NCT01605487RUPATADINEPHASE2ClinicalTrials.gov
NCT01481909RUPATADINEPHASE2/PHASE3ClinicalTrials.gov
NCT00199251RUPATADINEPHASE3ClinicalTrials.gov
NCT00199238RUPATADINEPHASE2ClinicalTrials.gov

NIH grants1,025

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTAFR papersNewest fiscal year
I01BX000853Oxidized Lipids and UV Immunosuppression212025
R01ES031087UVB radiation-generated microvesicle particles as effectors for photosensitivity102025
P30CA016672Cancer Center Support Grant82025
P30CA021765Cancer Center Support Grant (CCSG)72025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital32025
P30ES005605Environmental Health Sciences Research Center32025
T32AI060519Immunology and Infectious Diseases Training Program32025
P30CA068485Cancer Center Support Grant22025
P30DK054759Precision Medicine Center for Cystic Fibrosis22025
P30ES009089Center for Environmental Health in Northern Manhattan22025

1 to 10 of 1,025Source NIH's project files

See all 1,025 nih grants

Papers2,635

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Platelet-activating factor in multiple sclerosis: From peripheral inflammation to central neurodegeneration.Mult Scler Relat Disord202642735600PubTator, text miningPubMed
Platelet-activating factor-receptor signaling mediates solar-simulated light-induced extracellular vesicle release in human keratinocytes.Photochem Photobiol202642703052PubTator, text miningPubMed
Editorial Expression of Concern: Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086.Br J Cancer202642567899PubTator, text miningPubMed
Effects of Benzo[a]pyrene on Targeted Therapy Response and Platelet-Activating Factor-Receptor-Mediated Microvesicle Particle Release in Non-Small Cell Lung Cancer.Med Sci (Basel)202642346841PubTator, text miningPubMed
Integrated systems toxicology identifies TCDD-responsive targets linked to immune dysregulation and treatment response in psoriasis.Front Med (Lausanne)202642292208PubTator, text miningPubMed
Phomactin derivatives from an endophytic fungus Biatriospora peruviensis KMU22204 associated with Delphinium yunnanense and their PAFR antagonist activities.Phytochemistry202642176719PubTator, text miningPubMed
Ginsenoside Rh2 attenuates pyroptosis by inhibiting the PAFR/NF-κB signaling pathway in an osteoarthritis cell model.Protoplasma202642120779PubTator, text miningPubMed
Basophil FCER1A and PTAFR Gene Expression Profiles Correlate With Disease Severity in Chronic Spontaneous Urticaria.Clin Transl Allergy202641998824PubTator, text miningPubMed
Platelet-Activating Factor Pathway in Women With Metabolic Dysfunction-Associated Steatotic Liver Disease and Obesity.Obesity (Silver Spring)202641885053PubTator, text miningPubMed
Ocular Surface Microbiota-Derived Lipoteichoic Acid Promotes Dry Eye Disease by Inducing Corneal Inflammation.Invest Ophthalmol Vis Sci202641873899PubTator, text miningPubMed

1 to 10 of 2,635

See all 2,635 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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