Gene · 5724
PTAFR: platelet activating factor receptor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PTAFR: platelet activating factor receptor. Genes, record 5724. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5724
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P25105 | Platelet-activating factor receptor | 342 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents45
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58137 | P25105 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58138 | P25105 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58139 | P25105 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3608 | P25105 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3608 | P25105 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 687 | P25105 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 63977 | P25105 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 63978 | P25105 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 63979 | P25105 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 340 | P25105 | Espacenet |
1 to 10 of 45
See all 45 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials7
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07064707 | RUPATADINE | PHASE2 | ClinicalTrials.gov | |
| NCT03770923 | RUPATADINE | PHASE3 | ClinicalTrials.gov | |
| NCT02358265 | RUPATADINE | PHASE3 | ClinicalTrials.gov | |
| NCT01605487 | RUPATADINE | PHASE2 | ClinicalTrials.gov | |
| NCT01481909 | RUPATADINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT00199251 | RUPATADINE | PHASE3 | ClinicalTrials.gov | |
| NCT00199238 | RUPATADINE | PHASE2 | ClinicalTrials.gov |
NIH grants1,025
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PTAFR papers | Newest fiscal year |
|---|---|---|---|
| I01BX000853 | Oxidized Lipids and UV Immunosuppression | 21 | 2025 |
| R01ES031087 | UVB radiation-generated microvesicle particles as effectors for photosensitivity | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 7 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 3 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 3 | 2025 |
| T32AI060519 | Immunology and Infectious Diseases Training Program | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 2 | 2025 |
| P30DK054759 | Precision Medicine Center for Cystic Fibrosis | 2 | 2025 |
| P30ES009089 | Center for Environmental Health in Northern Manhattan | 2 | 2025 |
1 to 10 of 1,025Source NIH's project files
See all 1,025 nih grantsPapers2,635
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Platelet-activating factor in multiple sclerosis: From peripheral inflammation to central neurodegeneration. | Mult Scler Relat Disord | 2026 | 42735600 | PubTator, text mining | PubMed |
| Platelet-activating factor-receptor signaling mediates solar-simulated light-induced extracellular vesicle release in human keratinocytes. | Photochem Photobiol | 2026 | 42703052 | PubTator, text mining | PubMed |
| Editorial Expression of Concern: Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. | Br J Cancer | 2026 | 42567899 | PubTator, text mining | PubMed |
| Effects of Benzo[a]pyrene on Targeted Therapy Response and Platelet-Activating Factor-Receptor-Mediated Microvesicle Particle Release in Non-Small Cell Lung Cancer. | Med Sci (Basel) | 2026 | 42346841 | PubTator, text mining | PubMed |
| Integrated systems toxicology identifies TCDD-responsive targets linked to immune dysregulation and treatment response in psoriasis. | Front Med (Lausanne) | 2026 | 42292208 | PubTator, text mining | PubMed |
| Phomactin derivatives from an endophytic fungus Biatriospora peruviensis KMU22204 associated with Delphinium yunnanense and their PAFR antagonist activities. | Phytochemistry | 2026 | 42176719 | PubTator, text mining | PubMed |
| Ginsenoside Rh2 attenuates pyroptosis by inhibiting the PAFR/NF-κB signaling pathway in an osteoarthritis cell model. | Protoplasma | 2026 | 42120779 | PubTator, text mining | PubMed |
| Basophil FCER1A and PTAFR Gene Expression Profiles Correlate With Disease Severity in Chronic Spontaneous Urticaria. | Clin Transl Allergy | 2026 | 41998824 | PubTator, text mining | PubMed |
| Platelet-Activating Factor Pathway in Women With Metabolic Dysfunction-Associated Steatotic Liver Disease and Obesity. | Obesity (Silver Spring) | 2026 | 41885053 | PubTator, text mining | PubMed |
| Ocular Surface Microbiota-Derived Lipoteichoic Acid Promotes Dry Eye Disease by Inducing Corneal Inflammation. | Invest Ophthalmol Vis Sci | 2026 | 41873899 | PubTator, text mining | PubMed |
1 to 10 of 2,635
See all 2,635 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5724
GET https://conductscience.org/api/genes/v1/5724/patents?page=2