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PTEN: phosphatase and tensin homolog

1 protein, 205 patents, 0 drugs, 0 trials, 21,343 NIH grants and 76,175 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPTENHGNC
Namephosphatase and tensin homologHGNC
NCBI Gene ID5728NCBI Gene
HGNC IDHGNC:9588HGNC
EnsemblENSG00000171862NCBI Gene
Aliases10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, PTENgama, TEP1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P60484Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN40312Ensembl, GeneID, HGNCUniProt

Patents 205

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0352P60484Espacenet
JP 2026000906 A2026-01-06191P60484Espacenet
EP 4650780 A22025-11-199030P60484Espacenet
EP 4641201 A22025-10-299298P60484Espacenet
JP 2025157475 A2025-10-1559P60484Espacenet
JP 2025517969 A2025-06-129298P60484Espacenet
JP 2025517970 A2025-06-129030P60484Espacenet
US 12275766 B22025-04-15107P60484Espacenet
US 12133879 B22024-11-0552P60484Espacenet
JP 2024123008 A2024-09-107594P60484Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 21343

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant9592,025NIH's project files
P30CA008748Cancer Center Support Grant8012,025NIH's project files
P30CA006973Regional Oncology Research Center2102,025NIH's project files
P30CA016058Cancer Center Support Grant1752,025NIH's project files
P50CA097186The Pacific Northwest Prostate Cancer SPORE1142,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant1022,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant1012,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant962,025NIH's project files
P30CA068485Cancer Center Support Grant962,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant942,025NIH's project files

Papers 76175

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824995PubTator, text miningPubMed
42823177PubTator, text miningPubMed
42821469PubTator, text miningPubMed
42817923PubTator, text miningPubMed
42817108PubTator, text miningPubMed
42814286PubTator, text miningPubMed
42814223PubTator, text miningPubMed
42809709PubTator, text miningPubMed
42808379PubTator, text miningPubMed
42806734PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license