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Gene · 5731

PTGER1: prostaglandin E receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTGER1: prostaglandin E receptor 1. Genes, record 5731. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5731

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Gene

Symbol
PTGER1
HGNC
Name
prostaglandin E receptor 1
HGNC
NCBI Gene ID
5731
NCBI Gene
HGNC ID
HGNC:9593
HGNC
Ensembl
ENSG00000160951
NCBI Gene
Aliases
EP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P34995Prostaglandin E2 receptor EP1 subtype4021Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062654 A2026-04-1046P34995Espacenet
JP 2026004568 A2026-01-1459401P34995Espacenet
JP 2025529142 A2025-09-043619P34995Espacenet
US 12371689 B22025-07-293619P34995Espacenet
EP 4491229 A22025-01-15206P34995Espacenet
WO 2024230934 A12024-11-14331P34995Espacenet
JP 2023156353 A2023-10-2446P34995Espacenet
US 11446398 B22022-09-2067453P34995Espacenet
US 11400116 B22022-08-02342P34995Espacenet
JP 2022524081 A2022-04-27170424P34995Espacenet

1 to 10 of 23

See all 23 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALPROSTADILCHEMBL495Prostanoid EP1 receptor agonistAGONISTChEMBL
DINOPROSTONECHEMBL548Prostaglandin E2 receptor agonistAGONISTChEMBL
ONO-8539CHEMBL3912251Prostanoid EP1 receptor antagonistANTAGONISTChEMBL

Trials37

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 37

See all 37 trials

NIH grants1,217

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTGER1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
R01NS100947Inflammatory regulation of epileptogenesis after status epilepticus82025
R01HL058506G Protein-Coupled Receptor Regulation in Airway Myocytes72025
P30CA068485Cancer Center Support Grant62025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT62025
P30ES005605Environmental Health Sciences Research Center52025
P30CA086862Cancer Center Support Grant42025
P30ES006694Southwest Environmental Health Sciences Center42025
P42ES013661Iowa Superfund Research Program: Airborne PCBs: Sources, Exposures, Toxicities, Remediation32025
R01AI078908Control of Pulmonary Inflammation by Leukotriene E432025

1 to 10 of 1,217Source NIH's project files

See all 1,217 nih grants

Papers2,455

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Development of sustainable natural waste-reinforced epoxy composites for potential building applications.RSC Adv202642644081PubTator, text miningPubMed
A Three-Dimensional Hyaluronic Acid-Based Scaffold Model for Electroporation-Enhanced Resveratrol Therapy in Triple-Negative Breast Cancer.Cell Biochem Biophys202642599649PubTator, text miningPubMed
The dual pathological roles and targeted therapy of PGE2: from receptor signaling networks to disease microenvironment modulation.Front Pharmacol202642528719PubTator, text miningPubMed
The update of prostaglandin E2 receptor subtype 4 (EP4) in inflammatory diseases.Genes Dis202642494643PubTator, text miningPubMed
Retraction notice to "Identification of autophagy-related biomarker and analysis of immune infiltrates in diabetic nephropathy: PTGER1 protein macromolecular structure and function" [Int. J. Biol. Macromol. 311 (2025) 144063].
Int J Biol Macromol202642481317PubTator, text miningPubMed
Leishmanicidal Potential of Eugenia pyriformis Cambess. (Myrtaceae) Leaf Extracts: Metabolomics and Mechanism of Action.Chem Biodivers202642407029PubTator, text miningPubMed
Cardiovascular safety profile of prostaglandin E and prostacyclin analogues: Clinical reports and ex vivo studies on human coronary arteries.Prostaglandins Leukot Essent Fatty Acids202642385560PubTator, text miningPubMed
Redox-sensitive GPCR signaling drives Gq-dependent Ca2+ mobilization and cytokine production in human bronchial epithelial cells.Am J Physiol Cell Physiol202642314770PubTator, text miningPubMed
The bromodomain protein Bdf3 is sufficient to activate expression of a procyclin gene in bloodstream stage African trypanosomes.mSphere202642223268PubTator, text miningPubMed
Screening Epitopes Through Comparative Analysis of Children and Mice Immune Responses to Pertussis Toxin Subunits (S1-S5) Induced by Whole-Cell Pertussis Vaccination.Vaccines (Basel)202642188785PubTator, text miningPubMed

1 to 10 of 2,455

See all 2,455 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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