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Gene · 5732

PTGER2: prostaglandin E receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTGER2: prostaglandin E receptor 2. Genes, record 5732. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5732

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Gene

Symbol
PTGER2
HGNC
Name
prostaglandin E receptor 2
HGNC
NCBI Gene ID
5732
NCBI Gene
HGNC ID
HGNC:9594
HGNC
Ensembl
ENSG00000125384
NCBI Gene
Aliases
COX-2, EP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43116Prostaglandin E2 receptor EP2 subtype3585Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459402P43116Espacenet
JP 2025529142 A2025-09-043620P43116Espacenet
US 12371689 B22025-07-293620P43116Espacenet
EP 4491229 A22025-01-15207P43116Espacenet
WO 2024230934 A12024-11-14332P43116Espacenet
US 12006548 B22024-06-11471P43116Espacenet
US 11446398 B22022-09-2067454P43116Espacenet
US 11400116 B22022-08-02343P43116Espacenet
JP 2022524081 A2022-04-27170425P43116Espacenet
US 11078247 B22021-08-039119P43116Espacenet

1 to 10 of 30

See all 30 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALPROSTADILCHEMBL495Prostanoid EP2 receptor agonistAGONISTChEMBL
DINOPROSTONECHEMBL548Prostaglandin E2 receptor agonistAGONISTChEMBL
EVATANEPAGCHEMBL563646Prostanoid EP2 receptor agonistAGONISTChEMBL
OMIDENEPAGCHEMBL3707245Prostanoid EP2 receptor agonistAGONISTChEMBL
OMIDENEPAG ISOPROPYLCHEMBL4297666Prostanoid EP2 receptor agonistAGONISTChEMBL
SIMENEPAG ISOPROPYLCHEMBL2105710Prostanoid EP2 receptor agonistAGONISTChEMBL
TAPRENEPAG ISOPROPYLCHEMBL2105692Prostanoid EP2 receptor agonistAGONISTChEMBL

Trials51

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

1 to 10 of 51

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NIH grants1,955

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTGER2 papersNewest fiscal year
R01HL058506G Protein-Coupled Receptor Regulation in Airway Myocytes152025
R01NS100947Inflammatory regulation of epileptogenesis after status epilepticus142025
P30CA016672Cancer Center Support Grant132025
P30CA068485Cancer Center Support Grant92025
R01MH052716Neuroinflammation, Epigenetics and Male Vulnerability82025
R01AI078908Control of Pulmonary Inflammation by Leukotriene E472025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT62025
T32HL007749Multidisciplinary Training Program in Lung Disease62025
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease62025
P01AI039671Costimulatory Mechanisms of Autoimmunity52025

1 to 10 of 1,955Source NIH's project files

See all 1,955 nih grants

Papers3,629

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting EP2 overcomes osimertinib-tolerant persisters through metabolic and inflammatory reprogramming in non-small cell lung cancer.Int Immunopharmacol202642647987PubTator, text miningPubMed
A Three-Dimensional Hyaluronic Acid-Based Scaffold Model for Electroporation-Enhanced Resveratrol Therapy in Triple-Negative Breast Cancer.Cell Biochem Biophys202642599649PubTator, text miningPubMed
IFI30 reprograms glioblastoma-associated macrophage and induces immune evasion by MAFF/PTGS2 pathway.Acta Pharm Sin B202642592170PubTator, text miningPubMed
Non-Invasive Physical Plasma Regulates COX-2 via EP2/EP4 Expression in Periodontal Ligament Cells Under Inflammatory Conditions.Int J Mol Sci202642589366PubTator, text miningPubMed
Correction: Engineering with EP2/EP4 knockout and IL-15 transpresentation renders stem cell-derived NK cells self-persistent and resistant to PGE2 inhibition.Front Immunol202642582636PubTator, text miningPubMed
Immune cells harbor their own microbiome-derived metabolome: a new layer of immunometabolic regulation.Front Immunol202642582102PubTator, text miningPubMed
A Functional Variant of CYP4V2 Contributes to Asthma Susceptibility Through Methylation-Mediated Regulation of the Arachidonic Acid Pathway.J Asthma Allergy202642540736PubTator, text miningPubMed
The dual pathological roles and targeted therapy of PGE2: from receptor signaling networks to disease microenvironment modulation.Front Pharmacol202642528719PubTator, text miningPubMed
The update of prostaglandin E2 receptor subtype 4 (EP4) in inflammatory diseases.Genes Dis202642494643PubTator, text miningPubMed
Crocus sativus L.-derived lauric acid-functionalized gold nanoparticles induce ferroptosis in HeLa cells and reverse M2 macrophage polarization via the PGE2/EP2/cAMP-PKA signaling pathway: a network pharmacology-based study.
Front Pharmacol202642482776PubTator, text miningPubMed

1 to 10 of 3,629

See all 3,629 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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