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Gene · 5733

PTGER3: prostaglandin E receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTGER3: prostaglandin E receptor 3. Genes, record 5733. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5733

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Gene

Symbol
PTGER3
HGNC
Name
prostaglandin E receptor 3
HGNC
NCBI Gene ID
5733
NCBI Gene
HGNC ID
HGNC:9595
HGNC
Ensembl
ENSG00000050628
NCBI Gene
Aliases
EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3-VI, EP3e, PGE2-R, lnc003875
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43115Prostaglandin E2 receptor EP3 subtype3904Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459403P43115Espacenet
JP 2026004568 A2026-01-1459409P43115Espacenet
JP 2026004568 A2026-01-1459412P43115Espacenet
EP 4650780 A22025-11-194133P43115Espacenet
JP 2025517970 A2025-06-124133P43115Espacenet
EP 4491229 A22025-01-15214P43115Espacenet
WO 2024230934 A12024-11-14339P43115Espacenet
US 11446398 B22022-09-2067456P43115Espacenet
US 11446398 B22022-09-2067457P43115Espacenet
US 11446398 B22022-09-2067461P43115Espacenet

1 to 10 of 50

See all 50 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DINOPROSTONECHEMBL548Prostaglandin E2 receptor agonistAGONISTChEMBL
MISOPROSTOLCHEMBL606Prostanoid EP3 receptor agonistAGONISTChEMBL
SEPETAPROSTCHEMBL4297633Prostanoid EP3 receptor agonistAGONISTChEMBL

Trials136

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,467

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTGER3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30CA068485Cancer Center Support Grant72025
R01HL058506G Protein-Coupled Receptor Regulation in Airway Myocytes72025
R01NS100947Inflammatory regulation of epileptogenesis after status epilepticus72025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT52025
I01BX005399Modulating prostaglandin E2 receptor activity to improve pancreatic islet function32025
P30CA008748Cancer Center Support Grant32025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
P30DK020593Vanderbilt Diabetes Research Center32025
R01AI078908Control of Pulmonary Inflammation by Leukotriene E432025

1 to 10 of 1,467Source NIH's project files

See all 1,467 nih grants

Papers2,527

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mapping Pharmacogenomic Determinants of Adverse Drug Reactions in Hypertension: A Systematic Review.Pharmaceuticals (Basel)202642797533PubTator, text miningPubMed
EP3 receptor mediates calcium oxalate kidney stone formation via Ca²⁺/AKT and necroinflammation.Urolithiasis202642599300PubTator, text miningPubMed
The dual pathological roles and targeted therapy of PGE2: from receptor signaling networks to disease microenvironment modulation.Front Pharmacol202642528719PubTator, text miningPubMed
The update of prostaglandin E2 receptor subtype 4 (EP4) in inflammatory diseases.Genes Dis202642494643PubTator, text miningPubMed
Cardiovascular safety profile of prostaglandin E and prostacyclin analogues: Clinical reports and ex vivo studies on human coronary arteries.Prostaglandins Leukot Essent Fatty Acids202642385560PubTator, text miningPubMed
The Pivotal Role of Plant Derivatives and Eicosanoid Signaling Modulation in Counteracting Cardiomiopathy.Int J Mol Sci202642278379PubTator, text miningPubMed
Identification and validation of a seven-gene metastasis-associated prognostic model in breast cancer.Front Genet202642186460PubTator, text miningPubMed
Sex-specific alterations of niacin flush pathway biomarkers in schizophrenia.Psychoneuroendocrinology202642156190PubTator, text miningPubMed
Ethnopharmacological evaluation and metabolic mechanism of Sanjie Xiaoliu Granule in breast cancer with depression.Biol Proced Online202642151763PubTator, text miningPubMed
Chronic spontaneous urticaria treatments and purinergic signaling: a therapeutic possibility.J Mol Med (Berl)202641917502PubTator, text miningPubMed

1 to 10 of 2,527

See all 2,527 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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