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Gene · 5734

PTGER4: prostaglandin E receptor 4

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. PTGER4: prostaglandin E receptor 4. Genes, record 5734. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/5734

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
PTGER4
HGNC
Name
prostaglandin E receptor 4
HGNC
NCBI Gene ID
5734
NCBI Gene
HGNC ID
HGNC:9596
HGNC
Ensembl
ENSG00000171522
NCBI Gene
Aliases
EP4, EP4R
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35408Prostaglandin E2 receptor EP4 subtype48810Ensembl, GeneID, HGNC

Source UniProt

Patents55

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459414P35408Espacenet
JP 2025529142 A2025-09-043622P35408Espacenet
US 12371689 B22025-07-293622P35408Espacenet
EP 4491229 A22025-01-15219P35408Espacenet
EP 4463571 A12024-11-20240P35408Espacenet
WO 2024230934 A12024-11-14344P35408Espacenet
US 11884978 B22024-01-30689P35408Espacenet
US 11649281 B22023-05-1621P35408Espacenet
US 11446398 B22022-09-2067468P35408Espacenet
US 11400116 B22022-08-02345P35408Espacenet

1 to 10 of 55

See all 55 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DINOPROSTONECHEMBL548Prostaglandin E2 receptor agonistAGONISTChEMBL
GRAPIPRANTCHEMBL3039498Prostanoid EP4 receptor antagonistANTAGONISTChEMBL
RIVENPROSTCHEMBL303960Prostanoid EP4 receptor agonistAGONISTChEMBL
VORBIPIPRANTCHEMBL6067994Prostanoid EP4 receptor antagonistANTAGONISTChEMBL

Trials24

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05845450VORBIPIPRANTPHASE2ClinicalTrials.gov
NCT05774236DINOPROSTONEPHASE3ClinicalTrials.gov
NCT05761418DINOPROSTONEPHASE3ClinicalTrials.gov
NCT05342467DINOPROSTONEPHASE2ClinicalTrials.gov
NCT05205330VORBIPIPRANTPHASE1/PHASE2ClinicalTrials.gov
NCT05041101GRAPIPRANTPHASE1/PHASE22025-06-13ClinicalTrials.gov
NCT04505943DINOPROSTONEClinicalTrials.gov
NCT04505917DINOPROSTONEClinicalTrials.gov
NCT04301349DINOPROSTONEPHASE3ClinicalTrials.gov
NCT04299854DINOPROSTONEClinicalTrials.gov

1 to 10 of 24

See all 24 trials

NIH grants2,299

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations152025
P30CA068485Cancer Center Support Grant132025
P30CA016672Cancer Center Support Grant122025
R01HL058506G Protein-Coupled Receptor Regulation in Airway Myocytes122025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital112025
R01NS100947Inflammatory regulation of epileptogenesis after status epilepticus112025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes112025
P30CA134274UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT102025
U01DK062431IBD Gene Mapping by Clinical and Population Subset102025
U01DK062432Montreal-Boston Collaborative GRC102025

1 to 10 of 2,299Source NIH's project files

See all 2,299 nih grants

Papers4,106

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825038PubTator, text miningPubMed
42792812PubTator, text miningPubMed
42774409PubTator, text miningPubMed
42734705PubTator, text miningPubMed
42714824PubTator, text miningPubMed
42665772PubTator, text miningPubMed
42593614PubTator, text miningPubMed
42592170PubTator, text miningPubMed
42589366PubTator, text miningPubMed
42582636PubTator, text miningPubMed

1 to 10 of 4,106

See all 4,106 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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