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Gene · 5740

PTGIS: prostaglandin I2 synthase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTGIS: prostaglandin I2 synthase. Genes, record 5740. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5740

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Gene

Symbol
PTGIS
HGNC
Name
prostaglandin I2 synthase
HGNC
NCBI Gene ID
5740
NCBI Gene
HGNC ID
HGNC:9603
HGNC
Ensembl
ENSG00000124212
NCBI Gene
Aliases
CYP8, CYP8A1, PGIS, PTGI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16647Prostacyclin synthase5002Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459424Q16647Espacenet
EP 4650780 A22025-11-191112Q16647Espacenet
EP 4641201 A22025-10-29784Q16647Espacenet
EP 4641202 A22025-10-2942Q16647Espacenet
JP 2025529142 A2025-09-043627Q16647Espacenet
US 12371689 B22025-07-293627Q16647Espacenet
JP 2025517969 A2025-06-12784Q16647Espacenet
JP 2025517970 A2025-06-121112Q16647Espacenet
KR 1020250017231 A2025-02-0442Q16647Espacenet
US 11446398 B22022-09-2067494Q16647Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,105

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTGIS papersNewest fiscal year
R01HD072929Optimal Oxygenation in Neonatal Lung Injury62025
P30CA016672Cancer Center Support Grant42025
ZIABC005708Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers42025
P30CA046934University of Colorado Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30ES005605Environmental Health Sciences Research Center32025
U19AI095227Viral and Host Determinants of Infant and Childhood Allergy and Asthma32025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)22025
R01AG053217The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twins22025
R01AG077742Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption Study22025

1 to 10 of 1,105Source NIH's project files

See all 1,105 nih grants

Papers1,533

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integration of multi-omics Mendelian randomization, neuroimaging mediation, and functional validation identifies PYGL as a neuroprotective causal gene for stroke prognosis.Brain Res202642744168PubTator, text miningPubMed
Mitochondrial RNA modification in colorectal cancer: From single-cell analysis to machine learning-based risk modeling.Comput Biol Chem202642600521PubTator, text miningPubMed
Time series analysis reveals the effect of shear stress profile on endothelial gene expression.BMC Cardiovasc Disord202642414889PubTator, text miningPubMed
PTGIS inhibited osteogenic and promoted angiogenic differentiation of bone marrow mesenchymal stem cells via endoplasmic reticulum stress mediated PI3K/AKT signaling.Stem Cell Res Ther202642401884PubTator, text miningPubMed
What are the predominant factors predicting trend of post-traumatic growth for patients after bone tumour surgery? A longitudinal observational study.BMC Psychol202642387568PubTator, text miningPubMed
Post-traumatic growth in depression and its association with coping strategies: a cross-sectional study.East Asian Arch Psychiatry202642374948PubTator, text miningPubMed
Correction to "Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma".Oxid Med Cell Longev202642222932PubTator, text miningPubMed
Lipid Metabolic Rewiring During Continuous Prostate Cancer Progression Defines a Biologically Relevant Four-Gene Prognostic Signature.Biol Proced Online202642185987PubTator, text miningPubMed
Machine learning-based integration identifies lactylation biomarkers for prognosis prediction and tumor microenvironment modulation in bladder cancer.Transl Androl Urol202642164391PubTator, text miningPubMed
Targeting the Vim-PGI2 Pathway Enhances CD8+ T Cell-Mediated Antitumor Immunity in Breast Cancer.Hum Mutat202642058674PubTator, text miningPubMed

1 to 10 of 1,533

See all 1,533 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5740

GET https://conductscience.org/api/genes/v1/5740/patents?page=2