Gene · 5740
PTGIS: prostaglandin I2 synthase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PTGIS: prostaglandin I2 synthase. Genes, record 5740. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5740
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16647 | Prostacyclin synthase | 500 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59424 | Q16647 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1112 | Q16647 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 784 | Q16647 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 42 | Q16647 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3627 | Q16647 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3627 | Q16647 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 784 | Q16647 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1112 | Q16647 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 42 | Q16647 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 67494 | Q16647 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,105
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PTGIS papers | Newest fiscal year |
|---|---|---|---|
| R01HD072929 | Optimal Oxygenation in Neonatal Lung Injury | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| ZIABC005708 | Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers | 4 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 3 | 2025 |
| U19AI095227 | Viral and Host Determinants of Infant and Childhood Allergy and Asthma | 3 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 2 | 2025 |
| R01AG053217 | The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twins | 2 | 2025 |
| R01AG077742 | Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption Study | 2 | 2025 |
1 to 10 of 1,105Source NIH's project files
See all 1,105 nih grantsPapers1,533
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integration of multi-omics Mendelian randomization, neuroimaging mediation, and functional validation identifies PYGL as a neuroprotective causal gene for stroke prognosis. | Brain Res | 2026 | 42744168 | PubTator, text mining | PubMed |
| Mitochondrial RNA modification in colorectal cancer: From single-cell analysis to machine learning-based risk modeling. | Comput Biol Chem | 2026 | 42600521 | PubTator, text mining | PubMed |
| Time series analysis reveals the effect of shear stress profile on endothelial gene expression. | BMC Cardiovasc Disord | 2026 | 42414889 | PubTator, text mining | PubMed |
| PTGIS inhibited osteogenic and promoted angiogenic differentiation of bone marrow mesenchymal stem cells via endoplasmic reticulum stress mediated PI3K/AKT signaling. | Stem Cell Res Ther | 2026 | 42401884 | PubTator, text mining | PubMed |
| What are the predominant factors predicting trend of post-traumatic growth for patients after bone tumour surgery? A longitudinal observational study. | BMC Psychol | 2026 | 42387568 | PubTator, text mining | PubMed |
| Post-traumatic growth in depression and its association with coping strategies: a cross-sectional study. | East Asian Arch Psychiatry | 2026 | 42374948 | PubTator, text mining | PubMed |
| Correction to "Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma". | Oxid Med Cell Longev | 2026 | 42222932 | PubTator, text mining | PubMed |
| Lipid Metabolic Rewiring During Continuous Prostate Cancer Progression Defines a Biologically Relevant Four-Gene Prognostic Signature. | Biol Proced Online | 2026 | 42185987 | PubTator, text mining | PubMed |
| Machine learning-based integration identifies lactylation biomarkers for prognosis prediction and tumor microenvironment modulation in bladder cancer. | Transl Androl Urol | 2026 | 42164391 | PubTator, text mining | PubMed |
| Targeting the Vim-PGI2 Pathway Enhances CD8+ T Cell-Mediated Antitumor Immunity in Breast Cancer. | Hum Mutat | 2026 | 42058674 | PubTator, text mining | PubMed |
1 to 10 of 1,533
See all 1,533 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5740
GET https://conductscience.org/api/genes/v1/5740/patents?page=2