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PTGS1: prostaglandin-endoperoxide synthase 1

1 protein, 75 patents, 69 drugs, 1,632 trials, 3,624 NIH grants and 10,302 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPTGS1HGNC
Nameprostaglandin-endoperoxide synthase 1HGNC
NCBI Gene ID5742NCBI Gene
HGNC IDHGNC:9604HGNC
EnsemblENSG00000095303NCBI Gene
AliasesCOX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P23219Prostaglandin G/H synthase 15991Ensembl, GeneID, HGNCUniProt

Patents 75

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026000906 A2026-01-06114P23219Espacenet
EP 4650780 A22025-11-197904P23219Espacenet
EP 4641201 A22025-10-297999P23219Espacenet
JP 2025147176 A2025-10-0611057P23219Espacenet
JP 2025147176 A2025-10-0611058P23219Espacenet
JP 2025147176 A2025-10-0614682P23219Espacenet
JP 2025529142 A2025-09-047488P23219Espacenet
US 12371689 B22025-07-297488P23219Espacenet
JP 2025517969 A2025-06-127999P23219Espacenet
JP 2025517970 A2025-06-127904P23219Espacenet

Drugs 69

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACEMETACINCHEMBL189171Cyclooxygenase inhibitorINHIBITORChEMBL
ACETAMINOPHENCHEMBL112Cyclooxygenase inhibitorINHIBITORChEMBL
ALCLOFENACCHEMBL94081Cyclooxygenase-1 inhibitorINHIBITORChEMBL
ALOXIPRINCHEMBL2108222Cyclooxygenase inhibitorINHIBITORChEMBL
ANTIPYRINECHEMBL277474Cyclooxygenase-1 inhibitorINHIBITORChEMBL
APAZONECHEMBL1565476Cyclooxygenase inhibitorINHIBITORChEMBL
ASPIRINCHEMBL25Cyclooxygenase inhibitorINHIBITORChEMBL
BALSALAZIDECHEMBL1201346Cyclooxygenase inhibitorINHIBITORChEMBL
BALSALAZIDE DISODIUMCHEMBL1200760Cyclooxygenase inhibitorINHIBITORChEMBL
BENZYDAMINECHEMBL12610Cyclooxygenase inhibitorINHIBITORChEMBL

Trials 1632

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07606638NAPROXEN SODIUMClinicalTrials.gov
NCT07597239ASPIRINClinicalTrials.gov
NCT07573137IBUPROFENClinicalTrials.gov
NCT07571681NAPROXENPHASE2/PHASE3ClinicalTrials.gov
NCT07571681IBUPROFENPHASE2/PHASE3ClinicalTrials.gov
NCT07546370ACETAMINOPHENPHASE4ClinicalTrials.gov
NCT07546370NAPROXENPHASE4ClinicalTrials.gov
NCT07533721IBUPROFENClinicalTrials.gov
NCT07533487ACETAMINOPHENClinicalTrials.gov
NCT07525635ASPIRINEARLY_PHASE1ClinicalTrials.gov

NIH grants 3624

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant232,025NIH's project files
P30CA068485Cancer Center Support Grant152,025NIH's project files
P30ES001247Environmental Agents as Modulators of Disease Processes152,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center152,025NIH's project files
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease132,025NIH's project files
ZIAES025043Alterations In Pulmonary Immune Function And Host Resistance In COX Null Mice132,025NIH's project files
P30AG017265USC/UCLA Center on Biodemography and Population Health122,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant112,025NIH's project files
T32ES007091Training in Environmental Toxicology of Human Disease92,025NIH's project files
T32AI007306Immunologic Basis of Resistance and Hypersensitivity82,025NIH's project files

Papers 10302

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42815330PubTator, text miningPubMed
42813181PubTator, text miningPubMed
42800011PubTator, text miningPubMed
42793291PubTator, text miningPubMed
42789539PubTator, text miningPubMed
42773997PubTator, text miningPubMed
42735596PubTator, text miningPubMed
42685585PubTator, text miningPubMed
42650112PubTator, text miningPubMed
42631906PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license