ConductScience.org, home

Library / Genes

PTGS2: prostaglandin-endoperoxide synthase 2

1 protein, 184 patents, 83 drugs, 2,123 trials, 13,834 NIH grants and 59,073 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPTGS2HGNC
Nameprostaglandin-endoperoxide synthase 2HGNC
NCBI Gene ID5743NCBI Gene
HGNC IDHGNC:9605HGNC
EnsemblENSG00000073756NCBI Gene
AliasesCOX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P35354Prostaglandin G/H synthase 26047Ensembl, GeneID, HGNCUniProt

Patents 184

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026000906 A2026-01-061P35354Espacenet
EP 4667578 A22025-12-24212P35354Espacenet
EP 4650780 A22025-11-198238P35354Espacenet
EP 4641201 A22025-10-298410P35354Espacenet
JP 2025147176 A2025-10-0611060P35354Espacenet
JP 2025147176 A2025-10-0614683P35354Espacenet
JP 2025131621 A2025-09-09212P35354Espacenet
JP 2025529142 A2025-09-047489P35354Espacenet
WO 2025176817 A12025-08-2842P35354Espacenet
EP 4606910 A12025-08-2742P35354Espacenet

Drugs 83

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACECLOFENACCHEMBL93645Cyclooxygenase-2 inhibitorINHIBITORChEMBL
ACEMETACINCHEMBL189171Cyclooxygenase inhibitorINHIBITORChEMBL
ACETAMINOPHENCHEMBL112Cyclooxygenase inhibitorINHIBITORChEMBL
ALOXIPRINCHEMBL2108222Cyclooxygenase inhibitorINHIBITORChEMBL
APAZONECHEMBL1565476Cyclooxygenase inhibitorINHIBITORChEMBL
APRICOXIBCHEMBL1835207Cyclooxygenase-2 inhibitorINHIBITORChEMBL
ASPIRINCHEMBL25Cyclooxygenase inhibitorINHIBITORChEMBL
BALSALAZIDECHEMBL1201346Cyclooxygenase inhibitorINHIBITORChEMBL
BALSALAZIDE DISODIUMCHEMBL1200760Cyclooxygenase inhibitorINHIBITORChEMBL
BENZYDAMINECHEMBL12610Cyclooxygenase inhibitorINHIBITORChEMBL

Trials 2123

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07606638NAPROXEN SODIUMClinicalTrials.gov
NCT07597239ASPIRINClinicalTrials.gov
NCT07573137IBUPROFENClinicalTrials.gov
NCT07571681NAPROXENPHASE2/PHASE3ClinicalTrials.gov
NCT07571681IBUPROFENPHASE2/PHASE3ClinicalTrials.gov
NCT07549386ETORICOXIBPHASE3ClinicalTrials.gov
NCT07546370ACETAMINOPHENPHASE4ClinicalTrials.gov
NCT07546370NAPROXENPHASE4ClinicalTrials.gov
NCT07533721IBUPROFENClinicalTrials.gov
NCT07533487ACETAMINOPHENClinicalTrials.gov

NIH grants 13834

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1952,025NIH's project files
P30CA068485Cancer Center Support Grant822,025NIH's project files
P30CA008748Cancer Center Support Grant592,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)552,025NIH's project files
P30ES001247Environmental Agents as Modulators of Disease Processes382,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant362,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases342,025NIH's project files
R01ES004738Activated Macrophages and Ozone Toxicity342,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award312,025NIH's project files
R01DK062794The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulation302,025NIH's project files

Papers 59073

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824651PubTator, text miningPubMed
42816842PubTator, text miningPubMed
42805573PubTator, text miningPubMed
42805572PubTator, text miningPubMed
42802950PubTator, text miningPubMed
42800396PubTator, text miningPubMed
42797428PubTator, text miningPubMed
42796515PubTator, text miningPubMed
42789583PubTator, text miningPubMed
42789539PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license