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Gene · 57468

SLC12A5: solute carrier family 12 member 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC12A5: solute carrier family 12 member 5. Genes, record 57468. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57468

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Gene

Symbol
SLC12A5
HGNC
Name
solute carrier family 12 member 5
HGNC
NCBI Gene ID
57468
NCBI Gene
HGNC ID
HGNC:13818
HGNC
Ensembl
ENSG00000124140
NCBI Gene
Aliases
DEE34, EIEE34, EIG14, KCC2, KIAA1176, hKCC2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H2X9Solute carrier family 12 member 51,1393Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463970Q9H2X9Espacenet
EP 4641201 A22025-10-2913209Q9H2X9Espacenet
JP 2025529142 A2025-09-043992Q9H2X9Espacenet
US 12371689 B22025-07-293992Q9H2X9Espacenet
JP 2025517969 A2025-06-1213209Q9H2X9Espacenet
JP 2025032204 A2025-03-1135733Q9H2X9Espacenet
EP 4461818 A22024-11-1335733Q9H2X9Espacenet
JP 2023058610 A2023-04-2535733Q9H2X9Espacenet
US 11446398 B22022-09-2080362Q9H2X9Espacenet
US 11400116 B22022-08-021506Q9H2X9Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,247

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC12A5 papersNewest fiscal year
R01DK093501WNK-SPAK signaling in the Distal Nephron132025
R01NS102937CRH Dysregulation of Brainstem Autonomic Circuits Increases SUDEP Risk102025
UL1TR001863Yale Clinical and Translational Science Award52025
P30DA018343Yale/NIDA Neuroproteomics Center32025
P50HD103537Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt32025
P51OD010425Washington National Primate Research Center32025
R01DK051496WNK Kinase Regulation of Thiazide-sensitive NaCl Transport32025
R35NS116852Neuronal Ion and Volume Shifts After Acute Brain Injury32025
T32AG000255Training in age related neurodegenerative diseases32025
IK2BX005058Investigating the Genomic Architecture of Anxiety and Overlap with Mental Health Disorders in the Million Veteran Program.22025

1 to 10 of 1,247Source NIH's project files

See all 1,247 nih grants

Papers1,914

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
GABA Signaling in Glioma: Paradoxes and Therapeutic Perspectives.Curr Neuropharmacol202642786845PubTator, text miningPubMed
Neuroimmune regulation of visceral pain: roles of microglia, purinergic signaling, and neuroinflammation.Front Immunol202642725064PubTator, text miningPubMed
Network integration of neocortical Cajal-Retzius neurons shapes early cortical dynamics and contributes to their transient nature.Cell Commun Signal202642717359PubTator, text miningPubMed
Differential isoform-specific control of KCC2 function in developing and mature cortical neurons.EMBO Rep202642701150PubTator, text miningPubMed
Platelet-Rich Plasma Modulates Neuroinflammation in an iPSC Model of Sensory Neurons and Microglia.Int J Mol Sci202642653132PubTator, text miningPubMed
WNK-dependent phosphorylation of gephyrin tunes GABAA receptors at inhibitory synapses and modulates anxiety behavior.Proc Natl Acad Sci U S A202642640800PubTator, text miningPubMed
Maternal copper levels moderate the neuroprotective effect of zinc on early childhood development: evidence from a birth cohort and proteomic profiling.Front Nutr202642516235PubTator, text miningPubMed
Sex-Specific Mechanisms of Central Sensitization: A Narrative Review of the Neuroimmune Architecture of Chronic Pain.Cureus202642504361PubTator, text miningPubMed
Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors.Front Chem202642466359PubTator, text miningPubMed
Ionic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics.Int J Mol Sci202642450349PubTator, text miningPubMed

1 to 10 of 1,914

See all 1,914 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57468

GET https://conductscience.org/api/genes/v1/57468/patents