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PTK2: protein tyrosine kinase 2

1 protein, 54 patents, 7 drugs, 54 trials, 10,588 NIH grants and 28,100 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPTK2HGNC
Nameprotein tyrosine kinase 2HGNC
NCBI Gene ID5747NCBI Gene
HGNC IDHGNC:9611HGNC
EnsemblENSG00000169398NCBI Gene
AliasesFADK, FADK 1, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q05397Focal adhesion kinase 11,05240Ensembl, GeneID, HGNCUniProt

Patents 54

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1915226Q05397Espacenet
EP 4641201 A22025-10-2918157Q05397Espacenet
JP 2025517969 A2025-06-1218157Q05397Espacenet
JP 2025517970 A2025-06-1215226Q05397Espacenet
JP 2024123008 A2024-09-107954Q05397Espacenet
JP 2024123008 A2024-09-107959Q05397Espacenet
US 11726090 B22023-08-158Q05397Espacenet
KR 1020220127513 A2022-09-2011Q05397Espacenet
KR 1020220127515 A2022-09-2011Q05397Espacenet
US 11446398 B22022-09-2069060Q05397Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CEP-37440CHEMBL3951811Focal adhesion kinase 1 inhibitorINHIBITORChEMBL
CONTELTINIBCHEMBL3899477Focal adhesion kinase 1 inhibitorINHIBITORChEMBL
DEFACTINIBCHEMBL3137331Focal adhesion kinase 1 inhibitorINHIBITORChEMBL
GSK-2256098CHEMBL4742157Focal adhesion kinase 1 inhibitorINHIBITORChEMBL
IFEBEMTINIBCHEMBL3657311Focal adhesion kinase 1 inhibitorINHIBITORChEMBL
PF-00562271CHEMBL1084546Focal adhesion kinase 1 inhibitorINHIBITORChEMBL
VS-4718CHEMBL3040440Focal adhesion kinase 1 inhibitorINHIBITORChEMBL

Trials 54

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07441174IFEBEMTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07318324DEFACTINIBPHASE1ClinicalTrials.gov
NCT07174908IFEBEMTINIBPHASE3ClinicalTrials.gov
NCT07126158DEFACTINIBPHASE2ClinicalTrials.gov
NCT06946927IFEBEMTINIBPHASE1ClinicalTrials.gov
NCT06708663IFEBEMTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT06630260DEFACTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT06495125DEFACTINIBPHASE2ClinicalTrials.gov
NCT06487221DEFACTINIBPHASE2ClinicalTrials.gov
NCT06394804DEFACTINIBPHASE2ClinicalTrials.gov

NIH grants 10588

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1822,025NIH's project files
P30CA008748Cancer Center Support Grant812,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase472,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant442,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant362,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant312,025NIH's project files
P30CA068485Cancer Center Support Grant292,025NIH's project files
P30CA006973Regional Oncology Research Center252,025NIH's project files
P30CA016058Cancer Center Support Grant242,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program232,025NIH's project files

Papers 28100

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825378PubTator, text miningPubMed
42825158PubTator, text miningPubMed
42821458PubTator, text miningPubMed
42818077PubTator, text miningPubMed
42815951PubTator, text miningPubMed
42815638PubTator, text miningPubMed
42814800PubTator, text miningPubMed
42814290PubTator, text miningPubMed
42812889PubTator, text miningPubMed
42805401PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license