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RPTOR: regulatory associated protein of MTOR complex 1

1 protein, 25 patents, 1 drug, 11 trials, 4,724 NIH grants and 6,826 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRPTORHGNC
Nameregulatory associated protein of MTOR complex 1HGNC
NCBI Gene ID57521NCBI Gene
HGNC IDHGNC:30287HGNC
EnsemblENSG00000141564NCBI Gene
AliasesKIAA1303, KOG1, Mip1, raptorNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q8N122Regulatory-associated protein of mTOR1,33522Ensembl, GeneID, HGNCUniProt

Patents 25

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461316Q8N122Espacenet
EP 4650780 A22025-11-194489Q8N122Espacenet
EP 4641201 A22025-10-294034Q8N122Espacenet
JP 2025529142 A2025-09-043782Q8N122Espacenet
US 12371689 B22025-07-293782Q8N122Espacenet
JP 2025517969 A2025-06-124034Q8N122Espacenet
JP 2025517970 A2025-06-124489Q8N122Espacenet
US 11446398 B22022-09-2072456Q8N122Espacenet
JP 2022524081 A2022-04-27175427Q8N122Espacenet
US 10941451 B22021-03-0929Q8N122Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
INDOXIMODCHEMBL571209mTORC1 activatorACTIVATORChEMBL

Trials 11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05106296INDOXIMODPHASE1ClinicalTrials.gov
NCT04049669INDOXIMODPHASE2ClinicalTrials.gov
NCT03301636INDOXIMODPHASE22022-09-27ClinicalTrials.gov
NCT02835729INDOXIMODPHASE1ClinicalTrials.gov
NCT02502708INDOXIMODPHASE1ClinicalTrials.gov
NCT02460367INDOXIMODPHASE1ClinicalTrials.gov
NCT02077881INDOXIMODPHASE1/PHASE2ClinicalTrials.gov
NCT02073123INDOXIMODPHASE1/PHASE2ClinicalTrials.gov
NCT02052648INDOXIMODPHASE1/PHASE22024-03-27ClinicalTrials.gov
NCT01792050INDOXIMODPHASE2ClinicalTrials.gov

NIH grants 4724

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant682,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes472,025NIH's project files
P30CA008748Cancer Center Support Grant452,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)212,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)182,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center152,025NIH's project files
P30CA068485Cancer Center Support Grant152,025NIH's project files
P30CA006973Regional Oncology Research Center112,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)112,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028112,025NIH's project files

Papers 6826

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42817668PubTator, text miningPubMed
42807832PubTator, text miningPubMed
42779765PubTator, text miningPubMed
42767540PubTator, text miningPubMed
42730677PubTator, text miningPubMed
42727655PubTator, text miningPubMed
42722241PubTator, text miningPubMed
42703875PubTator, text miningPubMed
42633398PubTator, text miningPubMed
42621724PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license