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Gene · 57591

MRTFA: myocardin related transcription factor A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MRTFA: myocardin related transcription factor A. Genes, record 57591. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57591

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Gene

Symbol
MRTFA
HGNC
Name
myocardin related transcription factor A
HGNC
NCBI Gene ID
57591
NCBI Gene
HGNC ID
HGNC:14334
HGNC
Ensembl
ENSG00000196588
NCBI Gene
Aliases
BSAC, KIAA1438, MAL, MKL, MKL1, MRTF-A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q969V6Myocardin-related transcription factor A9312Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452976Q969V6Espacenet
JP 2026004568 A2026-01-1452979Q969V6Espacenet
EP 4641201 A22025-10-2912826Q969V6Espacenet
JP 2025517969 A2025-06-1212826Q969V6Espacenet
US 11446398 B22022-09-2049931Q969V6Espacenet
US 11446398 B22022-09-2049935Q969V6Espacenet
JP 2022524081 A2022-04-27152902Q969V6Espacenet
JP 2022524081 A2022-04-27152906Q969V6Espacenet
US 11078247 B22021-08-036832Q969V6Espacenet
JP 2019054813 A2019-04-11233411Q969V6Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,377

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMRTFA papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)122025
P50CA116201Mayo Clinic Breast Cancer SPORE92025
P30CA008748Cancer Center Support Grant82025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025
P30CA016056Roswell Park Cancer Center Support Grant52025
P30CA016359Cancer Center Support Grant52025
P30CA047904Cancer Center Support Grant52025
P30ES009089Center for Environmental Health in Northern Manhattan52025
R35CA232128Identification of Novel Oncogenic Signaling Pathways using Viral Perturbations52025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 1,377Source NIH's project files

See all 1,377 nih grants

Papers1,851

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal-to-Nuclear Signaling and 3D Spatio-Epigenomic Remodeling.Adv Sci (Weinh)202642801574PubTator, text miningPubMed
Twist1 Promotes Endothelial Phenotypic Transition and Unstable Plaque Phenotype During Atherosclerosis.Arterioscler Thromb Vasc Biol202642689320PubTator, text miningPubMed
Roflumilast Inhibits Fibrogenic Activation in Human Intestinal Myofibroblasts via Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling.Int J Mol Sci202642653130PubTator, text miningPubMed
Piezo1 Mechanotransduction in Skeletal Muscle: Convergence with Noncoding RNA Regulation in Myogenesis, Regeneration, and Sarcopenia.Int J Mol Sci202642653088PubTator, text miningPubMed
Transcript isoform switching during embryonic and post-hatch development of broiler breast muscle.Poult Sci202642617261PubTator, text miningPubMed
WISP1 Drives Intestinal Fibrosis in Crohn's Disease via Metabolic and Rho/ROCK/MRTF-Mediated Cytoskeletal Remodeling.Gastroenterology202642612881PubTator, text miningPubMed
Emerin acts as a mechanosensor linking force transmission and disease.Front Oncol202642597750PubTator, text miningPubMed
Targeting HDAC and proteostasis to eradicate quiescent cancer cells.Cancer Gene Ther202642595792PubTator, text miningPubMed
Functional interaction of HINT1 with MRTF-A: complex formation, protein stabilisation and transcriptional repression.Biol Chem202642550959PubTator, text miningPubMed
P95-HER2 promotes metastatic progression by biasing MRTFA dependent signaling.bioRxiv202642539230PubTator, text miningPubMed

1 to 10 of 1,851

See all 1,851 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57591

GET https://conductscience.org/api/genes/v1/57591/patents?page=2