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Gene · 5764

PTN: pleiotrophin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTN: pleiotrophin. Genes, record 5764. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5764

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Gene

Symbol
PTN
HGNC
Name
pleiotrophin
HGNC
NCBI Gene ID
5764
NCBI Gene
HGNC ID
HGNC:9630
HGNC
Ensembl
ENSG00000105894
NCBI Gene
Aliases
HARP, HB-GAM, HBBM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, OSF-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P21246Pleiotrophin1683Ensembl, GeneID, HGNC

Source UniProt

Patents75

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026090543 A2026-06-02325P21246Espacenet
JP 2026004568 A2026-01-1458241P21246Espacenet
JP 2025147176 A2025-10-0611089P21246Espacenet
JP 2025529142 A2025-09-047494P21246Espacenet
WO 2025166063 A12025-08-0713P21246Espacenet
US 12371689 B22025-07-297494P21246Espacenet
JP 2025032204 A2025-03-1134223P21246Espacenet
JP 2025028160 A2025-02-2811089P21246Espacenet
KR 1020250010750 A2025-01-2111089P21246Espacenet
KR 1020240176122 A2024-12-248P21246Espacenet

1 to 10 of 75

See all 75 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,319

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTN papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
P30CA021765Cancer Center Support Grant (CCSG)52025
UL1TR001863Yale Clinical and Translational Science Award52025
R01HL063199The role of beta 2 integrins in macrophage fusion42025
T32CA009686Training Grant In Tumor Biology42025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success42025
ZIAHD000640Regulation Of Childhood Growth42025
K12HD000850Pediatric Scientist Development Program32025
P30AG072980Arizona Alzheimer's Disease Research Center32025

1 to 10 of 1,319Source NIH's project files

See all 1,319 nih grants

Papers2,418

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Airway cell-cell communication in smoking through integration of spatial and single-cell transcriptomics.Respir Res202642827249PubTator, text miningPubMed
The Polycystic Kidney Disease Cyst Transcriptome Defined by Integrating Spatial, Single Nuclear, and Bulk Transcriptomics.Kidney360202642804341PubTator, text miningPubMed
Plasma and cerebrospinal fluid proteomics reveal distinct patterns of senescence and neuropathology in aging rhesus macaques.Geroscience202642799938PubTator, text miningPubMed
Single-Cell RNA Sequencing of Uterine Tissue from a 70-Day-Old Female Rabbit: Cellular Composition and Fibroblast-Associated Networks.Genes (Basel)202642793025PubTator, text miningPubMed
HMMR+ stromal cells drive human uterine development.Cell Discov202642706229PubTator, text miningPubMed
Integrated Bulk and Single-Cell Transcriptomic Analyses Identify a Five-Gene Signature Associated With Prognosis and the Tumor Microenvironment in Epstein-Barr Virus-Associated Gastric Cancer.Genet Res (Camb)202642667220PubTator, text miningPubMed
Deletion of Pleiotrophin protects against high-fat diet-induced liver metabolic disease, independently of the sexual dimorphism in dietary response.Mol Biomed202642622926PubTator, text miningPubMed
Pleiotrophin regulates presynaptic assembly and function through heparan sulfate-dependent binding to neurexin1.Cell Rep202642585021PubTator, text miningPubMed
ATP13A2 Promotes Endothelial Angiogenic Phenotypes and Is Associated With Poor Prognosis in Liver Hepatocellular Carcinoma.Mol Carcinog202642574576PubTator, text miningPubMed
Evaluation on the significance of miR-338-3p for preterm premature rupture of membranes with histologic chorioamnionitis.Placenta202642485913PubTator, text miningPubMed

1 to 10 of 2,418

See all 2,418 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5764

GET https://conductscience.org/api/genes/v1/5764/patents?page=2