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Gene · 57650

CIP2A: cellular inhibitor of PP2A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CIP2A: cellular inhibitor of PP2A. Genes, record 57650. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57650

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Gene

Symbol
CIP2A
HGNC
Name
cellular inhibitor of PP2A
HGNC
NCBI Gene ID
57650
NCBI Gene
HGNC ID
HGNC:29302
HGNC
Ensembl
ENSG00000163507
NCBI Gene
Aliases
KIAA1524, NOCIVA, p90
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TCG1Protein CIP2A9051Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459635Q8TCG1Espacenet
WO 2025259899 A12025-12-183Q8TCG1Espacenet
EP 4650780 A22025-11-193643Q8TCG1Espacenet
EP 4641201 A22025-10-293240Q8TCG1Espacenet
EP 4641202 A22025-10-294729Q8TCG1Espacenet
JP 2025529142 A2025-09-042291Q8TCG1Espacenet
US 12371689 B22025-07-292291Q8TCG1Espacenet
JP 2025517969 A2025-06-123240Q8TCG1Espacenet
JP 2025517970 A2025-06-123643Q8TCG1Espacenet
KR 1020250017231 A2025-02-044729Q8TCG1Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants663

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCIP2A papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
P30CA016058Cancer Center Support Grant42025
P30CA069533OHSU Knight Cancer Institute42025
P30CA013148Comprehensive Cancer Center Support Grant32025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant32025
T32CA229102Surgical Oncology Research Training Program32025
T32DE017551T-COHR: Training in Craniofacial and Oral Health Research32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA014195Cancer Center Support Grant (CCSG)22025

1 to 10 of 663Source NIH's project files

See all 663 nih grants

Papers1,316

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DDIAS shields vulnerable single-stranded DNA to direct neurogenesis and protect cancer cells.Mol Cell202642822412PubTator, text miningPubMed
Targeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a gBRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1.medRxiv202642818163PubTator, text miningPubMed
Activation of PP2A-B56a leads to aberrant EGFR signaling and proliferative phenotypes in PDAC.Mol Cancer Ther202642704219PubTator, text miningPubMed
Dynamic chromatin tethering of MDC1 regulates genome stability.Nucleic Acids Res202642703974PubTator, text miningPubMed
MAD2B guides chromosome stability in mitosis via the MAD2B-CIP2A signaling axis.J Mol Cell Biol202642667364PubTator, text miningPubMed
DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development.Cell202642636811PubTator, text miningPubMed
Mitotic single-stranded DNA suppression by DDIAS.Mol Cell202642636809PubTator, text miningPubMed
Development of a structurally distinct TopBP1 inhibitor that enhances PARP blockade and reverses osimertinib resistance.Sci Adv202642555732PubTator, text miningPubMed
CIP2A-TOPBP1 complex and PP2A dynamically regulate Polθ recruitment and phosphorylation at mitotic DNA double-strand breaks.Proc Natl Acad Sci U S A202642546199PubTator, text miningPubMed
PP2A: Decoding Its Structure, Regulation and Therapeutic Applications in Neurological Disorders.Curr Neuropharmacol202642522313PubTator, text miningPubMed

1 to 10 of 1,316

See all 1,316 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57650

GET https://conductscience.org/api/genes/v1/57650/patents?page=2