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Gene · 57674

RNF213: ring finger protein 213

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RNF213: ring finger protein 213. Genes, record 57674. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57674

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Gene

Symbol
RNF213
HGNC
Name
ring finger protein 213
HGNC
NCBI Gene ID
57674
NCBI Gene
HGNC ID
HGNC:14539
HGNC
Ensembl
ENSG00000173821
NCBI Gene
Aliases
ALO17, C17orf27, KIAA1554, KIAA1618, MYMY2, MYSTR, NET57
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q63HN8E3 ubiquitin-protein ligase RNF2135,2074Ensembl, GeneID, HGNC

Source UniProt

Patents8

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462280Q63HN8Espacenet
JP 2025529142 A2025-09-043751Q63HN8Espacenet
US 12371689 B22025-07-293751Q63HN8Espacenet
JP 2022141755 A2022-09-2996Q63HN8Espacenet
JP 2019054813 A2019-04-11242715Q63HN8Espacenet
JP 2017121241 A2017-07-13242715Q63HN8Espacenet
JP 2016519285 A2016-06-3096Q63HN8Espacenet
JP 2015516143 A2015-06-08242715Q63HN8Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants651

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRNF213 papersNewest fiscal year
P30CA016672Cancer Center Support Grant52025
P30CA008748Cancer Center Support Grant32025
P30CA036727Buffett Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
R01NS110395Endolysosomal Proteome Landscapes Through the Lens of Neurodegenerative Risk Alleles32025
R35GM142486Exploiting bacterial effector proteins to study human ubiquitin signaling32025
P30CA021765Cancer Center Support Grant (CCSG)22025
P30CA043703Case Comprehensive Cancer Center Support Grant22025
P30DK058404Molecular and Cellular Basis for Digestive Diseases22025
P30ES010126UNC Center for Environmental Health and Susceptibility22025

1 to 10 of 651Source NIH's project files

See all 651 nih grants

Papers1,364

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification and genotype-phenotype correlation of RNF213 p.R4810K and non- p.R4810K variants in Moyamoya disease in an Indian cohort.Front Neurol202642824198PubTator, text miningPubMed
ZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers.Mol Cell202642822417PubTator, text miningPubMed
Toxoplasma gondii GRA66 prevents premature egress driven by the host phospholipase RARRES3, independently of RNF213.bioRxiv202642818749PubTator, text miningPubMed
RNF213 regulates palmitate signaling through AAA+ and RZ-finger domains, a process enhanced by gain-of-function moyamoya disease-associated mutations.FEBS J202642681960PubTator, text miningPubMed
Plasma signatures of type 2 inflammation and vascular remodeling in moyamoya disease.J Neurol Sci202642664850PubTator, text miningPubMed
RNF213-dependent lytic destruction of Chlamydia-containing vacuoles activates host cell death pathways.Proc Natl Acad Sci U S A202642658761PubTator, text miningPubMed
Pulmonary Arterial Hypertension With Moyamoya Disease Harboring the RNF213 p.Arg4810Lys Variant Presenting a Favorable Response to Monotherapy: A Case Report.Pulm Circ202642657248PubTator, text miningPubMed
RNF213 in Panvascular Disease: A Molecular Hub Linking Genetic Susceptibility to Systemic Vasculopathy.Biomedicines202642652131PubTator, text miningPubMed
Independent Association of RNF213 p.R4810K With Extracranial Carotid Artery Disease Beyond Intracranial Atherosclerosis.Stroke202642644243PubTator, text miningPubMed
Pediatric moyamoya: current evidence and updates in evaluation and management.Curr Opin Pediatr202642627237PubTator, text miningPubMed

1 to 10 of 1,364

See all 1,364 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57674

GET https://conductscience.org/api/genes/v1/57674/grants?page=2