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PTPN1: protein tyrosine phosphatase non-receptor type 1

1 protein, 92 patents, 0 drugs, 0 trials, 2,932 NIH grants and 6,766 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPTPN1HGNC
Nameprotein tyrosine phosphatase non-receptor type 1HGNC
NCBI Gene ID5770NCBI Gene
HGNC IDHGNC:9642HGNC
EnsemblENSG00000196396NCBI Gene
AliasesPTP1BNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P18031Tyrosine-protein phosphatase non-receptor type 1435441Ensembl, GeneID, HGNCUniProt

Patents 92

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4694917 A12026-02-18640P18031Espacenet
EP 4650780 A22025-11-198982P18031Espacenet
JP 2025157475 A2025-10-1555P18031Espacenet
JP 2025529142 A2025-09-043632P18031Espacenet
US 12371689 B22025-07-293632P18031Espacenet
EP 4577200 A22025-07-024P18031Espacenet
JP 2025517970 A2025-06-128982P18031Espacenet
US 12297234 B22025-05-1356P18031Espacenet
EP 4426882 A12024-09-11235P18031Espacenet
EP 4426882 A12024-09-11236P18031Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2932

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01CA069202Structure/Function of Protein Tyrosine Phosphatases512,025NIH's project files
R01CA053840Protein Tyrosine Dephosphorylation & Signal Transduction402,025NIH's project files
P30CA045508CSHL Cancer Center Support Grant272,025NIH's project files
R01GM102187Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology162,025NIH's project files
R35GM133769Mapping and Exploiting the Internal Wiring of Structurally Dynamic Phosphatases152,025NIH's project files
R01CA142746Subcellular enzyme-instructed self-assembly for molecular anticancer nanomedicines142,025NIH's project files
P30CA008748Cancer Center Support Grant132,025NIH's project files
P30CA016672Cancer Center Support Grant112,025NIH's project files
P30CA023168Cancer Center Support Grant102,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase92,025NIH's project files

Papers 6766

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824679PubTator, text miningPubMed
42814531PubTator, text miningPubMed
42801824PubTator, text miningPubMed
42798543PubTator, text miningPubMed
42784515PubTator, text miningPubMed
42778726PubTator, text miningPubMed
42769439PubTator, text miningPubMed
42741040PubTator, text miningPubMed
42736664PubTator, text miningPubMed
42731393PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license