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Gene · 5771

PTPN2: protein tyrosine phosphatase non-receptor type 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTPN2: protein tyrosine phosphatase non-receptor type 2. Genes, record 5771. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5771

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Gene

Symbol
PTPN2
HGNC
Name
protein tyrosine phosphatase non-receptor type 2
HGNC
NCBI Gene ID
5771
NCBI Gene
HGNC ID
HGNC:9650
HGNC
Ensembl
ENSG00000175354
NCBI Gene
Aliases
PTN2, PTPT, TC-PTP, TC45, TC48, TCELLPTP, TCPTP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17706Tyrosine-protein phosphatase non-receptor type 241514Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460076P17706Espacenet
EP 4650780 A22025-11-194789P17706Espacenet
EP 4641201 A22025-10-294358P17706Espacenet
JP 2025529142 A2025-09-043633P17706Espacenet
US 12371689 B22025-07-293633P17706Espacenet
JP 2025517969 A2025-06-124358P17706Espacenet
JP 2025517970 A2025-06-124789P17706Espacenet
EP 4426882 A12024-09-11237P17706Espacenet
EP 4426882 A12024-09-11238P17706Espacenet
US 11446398 B22022-09-2069168P17706Espacenet

1 to 10 of 17

See all 17 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,653

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTPN2 papersNewest fiscal year
R01DK091281A Novel Role for PTPN2 in Intestinal Epithelial Barrier Regulation232025
R01CA069202Structure/Function of Protein Tyrosine Phosphatases212025
R01CA053840Protein Tyrosine Dephosphorylation & Signal Transduction132025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations112025
P01AI042288Immune Function and the Progression to Type 1 Diabetes82025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital82025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes72025
U01DK062431IBD Gene Mapping by Clinical and Population Subset72025
U01DK062432Montreal-Boston Collaborative GRC72025
P30CA008748Cancer Center Support Grant62025

1 to 10 of 1,653Source NIH's project files

See all 1,653 nih grants

Papers2,250

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Towards Precision Medicine in Inflammatory Bowel Diseases: Pharmacogenetic Predictors of Ustekinumab Effectiveness and Persistence.Pharmaceuticals (Basel)202642797473PubTator, text miningPubMed
PTPN2 Deletion Enhances CAR-T Effector Function and CNS Trafficking in a Non-Human Primate Model.Blood Adv202642685352PubTator, text miningPubMed
PTPN1 and PTPN2 cooperatively set interferon responsiveness thresholds that govern cancer immune evasion.Proc Natl Acad Sci U S A202642579487PubTator, text miningPubMed
Molecular Mechanisms and Targeted Therapies of PTPN2 in Metabolic Diseases: A Review.Biomolecules202642509809PubTator, text miningPubMed
PTPN2-Associated Immune Dysregulation Presenting With Autoimmune Cytopenias, Lymphoproliferation, and Recurrent Intussusception.Pediatr Blood Cancer202642488986PubTator, text miningPubMed
Uncompetitive Allosteric Inhibition of PTP1B by BP-1-102 Reveals a Potential Dual-Target Strategy toward the PTP1B-STAT3 Oncogenic Axis: Biochemical and Computational Evidence.ACS Med Chem Lett202642445032PubTator, text miningPubMed
Whole genome-based polygenic risk score and structural variation analysis in Korean patients with inflammatory bowel disease.BMB Rep202642226727PubTator, text miningPubMed
Calix[4]Arene α-Ketophosphonic Acids as Photoactivatable Inhibitors of Protein Tyrosine Phosphatases.Chem Biodivers202642216850PubTator, text miningPubMed
Reprogramming the diseased liver: antioxidant-engineered mRNA nanoparticles as microenvironment modulators in MAFLD.Immunometabolism (Cobham)202642163952PubTator, text miningPubMed
Unraveling the layers of epigenetic control in respiratory antiviral defense.J Virol202642159289PubTator, text miningPubMed

1 to 10 of 2,250

See all 2,250 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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