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Gene · 57761

TRIB3: tribbles pseudokinase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TRIB3: tribbles pseudokinase 3. Genes, record 57761. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57761

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Gene

Symbol
TRIB3
HGNC
Name
tribbles pseudokinase 3
HGNC
NCBI Gene ID
57761
NCBI Gene
HGNC ID
HGNC:16228
HGNC
Ensembl
ENSG00000101255
NCBI Gene
Aliases
C20orf97, NIPK, SINK, SKIP3, TRB3, dJ1103G7.3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96RU7Tribbles homolog 33580Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 11446398 B22022-09-2092134Q96RU7Espacenet
JP 2022524081 A2022-04-27195105Q96RU7Espacenet
US 11078247 B22021-08-0311964Q96RU7Espacenet
JP 2017121240 A2017-07-1355709Q96RU7Espacenet
JP 2016127833 A2016-07-14378Q96RU7Espacenet
WO 2016103269 A12016-06-303142Q96RU7Espacenet
JP 2015518704 A2015-07-0655709Q96RU7Espacenet
US 8389207 B22013-03-054Q96RU7Espacenet
JP 2013505232 A2013-02-14378Q96RU7Espacenet
WO 2011034421 A12011-03-24325Q96RU7Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,288

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTRIB3 papersNewest fiscal year
P30DK036836Diabetes Research Center122025
P30CA016672Cancer Center Support Grant82025
P30CA016058Cancer Center Support Grant52025
P30DK079626UAB Diabetes Research Center52025
P30DK020579Diabetes Research Center42025
P30DK056336UAB Nutrition Obesity Research Center (NORC)42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA008748Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30CA091842Cancer Center Support Grant32025

1 to 10 of 1,288Source NIH's project files

See all 1,288 nih grants

Papers2,228

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Hydrogel delivery of demineralized bone matrix augmented with ROS-triggered biomineralization and Trb3 activation for enhanced bone regeneration.Biomaterials202742570639PubTator, text miningPubMed
Modulation of Endoplasmic Reticulum Stress via CEBPB: A Potential Molecular Link to Therapeutic Action in Substance Use Disorders.CNS Neurosci Ther202642808816PubTator, text miningPubMed
HPRT1 drives mitochondrial metabolic reprogramming and immunosuppressive microenvironment in oral squamous cell carcinoma.Apoptosis202642791403PubTator, text miningPubMed
GCH1, identified by a ferroptosis-related prognostic model, contributes to progression and drug resistance of esophageal cancer.Chin J Cancer Res202642713103PubTator, text miningPubMed
A Lipid Metabolism-Related Gene Signature Stratifies Prognosis and Reflects Metabolic-Immune Heterogeneity in Head and Neck Squamous Cell Carcinoma.Oral Dis202642695225PubTator, text miningPubMed
SIAH1-Mediated Ubiquitination and Degradation of TRIB3 Modulate Osteogenic and Adipogenic Differentiation.Stem Cells Int202642662480PubTator, text miningPubMed
ATF4 activates a transcriptional program that chronically suppresses mTOR activity and promotes neurodegeneration in Parkinson disease models.Cell Rep202642599806PubTator, text miningPubMed
Corrigendum to "Integrative in silico analysis identifies functionally and regulatively relevant nsSNPs in the TRIB3 gene" [Comput. Biol. Chem. 124 (2026) 109227].Comput Biol Chem202642586862PubTator, text miningPubMed
TRIB3 promotes lipid accumulation and lipogenesis in esophageal cancer progression.Cell Signal202642562152PubTator, text miningPubMed
Calcium Phosphate Nanoparticle Delivery of siTRIB3 Inhibits EMT and Stemness in NSCLC.Int J Nanomedicine202642559326PubTator, text miningPubMed

1 to 10 of 2,228

See all 2,228 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/57761

GET https://conductscience.org/api/genes/v1/57761/patents?page=2