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PTPN6: protein tyrosine phosphatase non-receptor type 6

1 protein, 61 patents, 0 drugs, 0 trials, 2,960 NIH grants and 4,688 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPTPN6HGNC
Nameprotein tyrosine phosphatase non-receptor type 6HGNC
NCBI Gene ID5777NCBI Gene
HGNC IDHGNC:9658HGNC
EnsemblENSG00000111679NCBI Gene
AliasesHCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29350Tyrosine-protein phosphatase non-receptor type 659514Ensembl, GeneID, HGNCUniProt

Patents 61

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026128487 A12026-06-18281P29350Espacenet
JP 2026004568 A2026-01-1460087P29350Espacenet
JP 2025537284 A2025-11-14281P29350Espacenet
JP 2025500465 A2025-01-0961P29350Espacenet
WO 2024261480 A12024-12-2659P29350Espacenet
JP 2024149818 A2024-10-185P29350Espacenet
EP 4426882 A12024-09-11241P29350Espacenet
US 11884978 B22024-01-30690P29350Espacenet
JP 2023123507 A2023-09-05212P29350Espacenet
JP 2022546315 A2022-11-0434P29350Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2960

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant202,025NIH's project files
U01DA0411486/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU132,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
U01DA04102210/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT SRI112,025NIH's project files
U01DA04102511/21 ABCD-USA Consortium: Research Project Site at UWM112,025NIH's project files
U01DA0410895/21 ABCD-USA Consortium: Research Project Site at UC San Diego112,025NIH's project files
U01DA04109313/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT MUSC112,025NIH's project files
U01DA0411069/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MICHIGAN112,025NIH's project files
U01DA0411203/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MINNESOTA112,025NIH's project files
U01DA0411341/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U UTAH112,025NIH's project files

Papers 4688

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821487PubTator, text miningPubMed
42762958PubTator, text miningPubMed
42640988PubTator, text miningPubMed
42621516PubTator, text miningPubMed
42545195PubTator, text miningPubMed
42543245PubTator, text miningPubMed
42487683PubTator, text miningPubMed
42447672PubTator, text miningPubMed
42445428PubTator, text miningPubMed
42439989PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license