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Gene · 57804

POLD4: DNA polymerase delta 4, accessory subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POLD4: DNA polymerase delta 4, accessory subunit. Genes, record 57804. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57804

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Gene

Symbol
POLD4
HGNC
Name
DNA polymerase delta 4, accessory subunit
HGNC
NCBI Gene ID
57804
NCBI Gene
HGNC ID
HGNC:14106
HGNC
Ensembl
ENSG00000175482
NCBI Gene
Aliases
POLDS, p12
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HCU8DNA polymerase delta subunit 41077Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458468Q9HCU8Espacenet
WO 2025181335 A12025-09-046Q9HCU8Espacenet
US 11884978 B22024-01-30670Q9HCU8Espacenet
US 11446398 B22022-09-2065001Q9HCU8Espacenet
JP 2022524081 A2022-04-27167972Q9HCU8Espacenet
EP 3504344 A12019-07-03859Q9HCU8Espacenet
JP 2019054813 A2019-04-11238903Q9HCU8Espacenet
US 9745631 B22017-08-2974Q9HCU8Espacenet
JP 2017121241 A2017-07-13238903Q9HCU8Espacenet
JP 2015516143 A2015-06-08238903Q9HCU8Espacenet

1 to 10 of 16

See all 16 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASPACYTARABINECHEMBL4297599DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CLOFARABINECHEMBL1750DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CYTARABINECHEMBL803DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
FLUDARABINE PHOSPHATECHEMBL1096882DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINECHEMBL888DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINE HYDROCHLORIDECHEMBL1637DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
TROXACITABINECHEMBL359164DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL

Trials4,186

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766GEMCITABINEPHASE3ClinicalTrials.gov
NCT07604233CYTARABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07603557FLUDARABINE PHOSPHATEPHASE2ClinicalTrials.gov
NCT07602140GEMCITABINEPHASE2ClinicalTrials.gov
NCT07598318GEMCITABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07588360CYTARABINEClinicalTrials.gov
NCT07583888CYTARABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07579195GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07575191GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07570849GEMCITABINEPHASE2ClinicalTrials.gov

1 to 10 of 4,186

See all 4,186 trials

NIH grants356

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOLD4 papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P30CA036727Buffett Cancer Center Support Grant42025
ZIAES065070Structure-Function Studies Of DNA Replication Fidelity42025
P01CA092584Structural Cell Biology of DNA Repair Machines32025
P30ES010126UNC Center for Environmental Health and Susceptibility32025
P01CA100730Retrovirus Models of Cancer22025
P30CA016086Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30CA044579University of Virginia Cancer Center Support Grant22025
P30CA086862Cancer Center Support Grant22025

1 to 10 of 356Source NIH's project files

See all 356 nih grants

Papers492

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Indel pattern-guided repair mapping reveals genome-wide DNA repair networks in CRISPR/Cas9 editing.Nucleic Acids Res202641891877PubTator, text miningPubMed
Meeting abstracts from the Annual Conference "Clinical Genetics of Cancer 2024".Hered Cancer Clin Pract202641781972PubTator, text miningPubMed
ZEB1 Promotes Alternate Lengthening of Telomeres at Multiple Levels.Cancers (Basel)202641681971PubTator, text miningPubMed
Differential functions of human DNA polymerase delta with p12 variants during DNA replication and DNA damage response.Mol Biol Cell202641671062PubTator, text miningPubMed
CRISPR-Cas9-Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real-Time MRI Monitoring.Adv Sci (Weinh)202641498761PubTator, text miningPubMed
The interplay of prenatal stress and prenatal depression in Chinese couples: based on the actor-partner interdependence model.Front Psychiatry202540821021PubTator, text miningPubMed
Construction and validation of a prognostic model for glioma: an analysis based on mismatch repair-related genes and their correlation with clinicopathological features.Transl Cancer Res202540530129PubTator, text miningPubMed
Global DNA methylation differences involving germline structural variation impact gene expression in pediatric brain tumors.Nat Commun202540399292PubTator, text miningPubMed
The p12 Subunit Choreographs the Regulation and Functions of Two Forms of DNA Polymerase δ in Mammalian Cells.Genes (Basel)202540004517PubTator, text miningPubMed
Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA.J Biol Chem202539993528PubTator, text miningPubMed

1 to 10 of 492

See all 492 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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