Gene · 57804
POLD4: DNA polymerase delta 4, accessory subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. POLD4: DNA polymerase delta 4, accessory subunit. Genes, record 57804. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/57804
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9HCU8 | DNA polymerase delta subunit 4 | 107 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58468 | Q9HCU8 | Espacenet |
| WO 2025181335 A1 | 2025-09-04 | 6 | Q9HCU8 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 670 | Q9HCU8 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 65001 | Q9HCU8 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 167972 | Q9HCU8 | Espacenet |
| EP 3504344 A1 | 2019-07-03 | 859 | Q9HCU8 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 238903 | Q9HCU8 | Espacenet |
| US 9745631 B2 | 2017-08-29 | 74 | Q9HCU8 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 238903 | Q9HCU8 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 238903 | Q9HCU8 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ASPACYTARABINE | CHEMBL4297599 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| CLOFARABINE | CHEMBL1750 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| CYTARABINE | CHEMBL803 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| FLUDARABINE PHOSPHATE | CHEMBL1096882 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| GEMCITABINE | CHEMBL888 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| GEMCITABINE HYDROCHLORIDE | CHEMBL1637 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| TROXACITABINE | CHEMBL359164 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
Trials4,186
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604766 | GEMCITABINE | PHASE3 | ClinicalTrials.gov | |
| NCT07604233 | CYTARABINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07603557 | FLUDARABINE PHOSPHATE | PHASE2 | ClinicalTrials.gov | |
| NCT07602140 | GEMCITABINE | PHASE2 | ClinicalTrials.gov | |
| NCT07598318 | GEMCITABINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07588360 | CYTARABINE | ClinicalTrials.gov | ||
| NCT07583888 | CYTARABINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07579195 | GEMCITABINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07575191 | GEMCITABINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07570849 | GEMCITABINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 4,186
See all 4,186 trialsNIH grants356
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | POLD4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 4 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 4 | 2025 |
| ZIAES065070 | Structure-Function Studies Of DNA Replication Fidelity | 4 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 3 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 3 | 2025 |
| P01CA100730 | Retrovirus Models of Cancer | 2 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 2 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 356Source NIH's project files
See all 356 nih grantsPapers492
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Indel pattern-guided repair mapping reveals genome-wide DNA repair networks in CRISPR/Cas9 editing. | Nucleic Acids Res | 2026 | 41891877 | PubTator, text mining | PubMed |
| Meeting abstracts from the Annual Conference "Clinical Genetics of Cancer 2024". | Hered Cancer Clin Pract | 2026 | 41781972 | PubTator, text mining | PubMed |
| ZEB1 Promotes Alternate Lengthening of Telomeres at Multiple Levels. | Cancers (Basel) | 2026 | 41681971 | PubTator, text mining | PubMed |
| Differential functions of human DNA polymerase delta with p12 variants during DNA replication and DNA damage response. | Mol Biol Cell | 2026 | 41671062 | PubTator, text mining | PubMed |
| CRISPR-Cas9-Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real-Time MRI Monitoring. | Adv Sci (Weinh) | 2026 | 41498761 | PubTator, text mining | PubMed |
| The interplay of prenatal stress and prenatal depression in Chinese couples: based on the actor-partner interdependence model. | Front Psychiatry | 2025 | 40821021 | PubTator, text mining | PubMed |
| Construction and validation of a prognostic model for glioma: an analysis based on mismatch repair-related genes and their correlation with clinicopathological features. | Transl Cancer Res | 2025 | 40530129 | PubTator, text mining | PubMed |
| Global DNA methylation differences involving germline structural variation impact gene expression in pediatric brain tumors. | Nat Commun | 2025 | 40399292 | PubTator, text mining | PubMed |
| The p12 Subunit Choreographs the Regulation and Functions of Two Forms of DNA Polymerase δ in Mammalian Cells. | Genes (Basel) | 2025 | 40004517 | PubTator, text mining | PubMed |
| Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA. | J Biol Chem | 2025 | 39993528 | PubTator, text mining | PubMed |
1 to 10 of 492
See all 492 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/57804
GET https://conductscience.org/api/genes/v1/57804/patents