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PTPN11: protein tyrosine phosphatase non-receptor type 11

1 protein, 52 patents, 1 drug, 2 trials, 7,408 NIH grants and 15,170 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPTPN11HGNC
Nameprotein tyrosine phosphatase non-receptor type 11HGNC
NCBI Gene ID5781NCBI Gene
HGNC IDHGNC:9644HGNC
EnsemblENSG00000179295NCBI Gene
AliasesBPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP-2, SHP2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q06124Tyrosine-protein phosphatase non-receptor type 11593116Ensembl, GeneID, HGNCUniProt

Patents 52

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196597Q06124Espacenet
EP 4641201 A22025-10-296345Q06124Espacenet
JP 2025517969 A2025-06-126345Q06124Espacenet
JP 2025517970 A2025-06-126597Q06124Espacenet
US 12297234 B22025-05-1365Q06124Espacenet
US 12130281 B22024-10-2961Q06124Espacenet
JP 2024123008 A2024-09-107927Q06124Espacenet
JP 2024528705 A2024-07-307Q06124Espacenet
EP 4373582 A12024-05-297Q06124Espacenet
US 11993635 B22024-05-2865Q06124Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BATOPROTAFIBCHEMBL4650521Protein-tyrosine phosphatase 2C inhibitorINHIBITORChEMBL

Trials 2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04294160BATOPROTAFIBPHASE1ClinicalTrials.gov
NCT04292119BATOPROTAFIBPHASE1/PHASE2ClinicalTrials.gov

NIH grants 7408

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1262,025NIH's project files
P30CA008748Cancer Center Support Grant1102,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)442,025NIH's project files
R01CA069202Structure/Function of Protein Tyrosine Phosphatases402,025NIH's project files
P30CA016058Cancer Center Support Grant312,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant272,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant272,025NIH's project files
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement272,025NIH's project files
R01CA077955H. Pylori Relationship to Digestive Diseases and Cancer252,025NIH's project files
U10CA180899Children's Oncology Group Statistics and Data Center242,025NIH's project files

Papers 15170

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823268PubTator, text miningPubMed
42821569PubTator, text miningPubMed
42820267PubTator, text miningPubMed
42820178PubTator, text miningPubMed
42818859PubTator, text miningPubMed
42812104PubTator, text miningPubMed
42810811PubTator, text miningPubMed
42793099PubTator, text miningPubMed
42783456PubTator, text miningPubMed
42781550PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license