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Gene · 5798

PTPRN: protein tyrosine phosphatase receptor type N

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTPRN: protein tyrosine phosphatase receptor type N. Genes, record 5798. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5798

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Gene

Symbol
PTPRN
HGNC
Name
protein tyrosine phosphatase receptor type N
HGNC
NCBI Gene ID
5798
NCBI Gene
HGNC ID
HGNC:9676
HGNC
Ensembl
ENSG00000054356
NCBI Gene
Aliases
IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16849Receptor-type tyrosine-protein phosphatase-like N9796Ensembl, GeneID, HGNC

Source UniProt

Patents238

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4698223 A22026-02-2519Q16849Espacenet
JP 2026004568 A2026-01-1460168Q16849Espacenet
US 12502436 B22025-12-232028Q16849Espacenet
US 12502436 B22025-12-232074Q16849Espacenet
US 12502436 B22025-12-232198Q16849Espacenet
US 12502436 B22025-12-232260Q16849Espacenet
US 12502436 B22025-12-232488Q16849Espacenet
JP 2025181835 A2025-12-112028Q16849Espacenet
JP 2025181835 A2025-12-112074Q16849Espacenet
JP 2025181835 A2025-12-112198Q16849Espacenet

1 to 10 of 238

See all 238 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,442

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTPRN papersNewest fiscal year
R01DK032083Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes682025
P30DK017047Diabetes Research Center402025
P30DK116073University of Colorado Anschutz Medical Campus DRC242025
P01AI042288Immune Function and the Progression to Type 1 Diabetes222025
P30DK045735Yale Diabetes Research Center192025
U01DK103282Type 1 Diabetes TrialNet Clinical Network Hub182025
R01DK057846Modulating pathogenic T cells in Type 1 diabetes152025
UL1TR001863Yale Clinical and Translational Science Award152025
P30DK020572Michigan Diabetes Research Center (MDRC)142025
P30DK097512Indiana Diabetes Research Center142025

1 to 10 of 1,442Source NIH's project files

See all 1,442 nih grants

Papers3,241

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Performance assessment of a novel fully automated ELISA for anti-IA2 autoantibody detection in type 1 diabetes.Clin Chim Acta202642822623PubTator, text miningPubMed
Neurexin mediates neuropeptide release from cholinergic motor neurons through dense-core vesicle localization.bioRxiv202642818522PubTator, text miningPubMed
Single Autoantibody Positivity in Pediatric Type 1 Diabetes: Serological Profiles, Clinical Trajectories and Implications for Early Disease Monitoring-A Case Series of Seven Patients.Life (Basel)202642795365PubTator, text miningPubMed
A Case of Dual Endocrinopathies Induced by Pembrolizumab Following Treatment for Non-small Cell Lung Cancer: Type 1 Diabetes and Hyperthyroidism/Autoimmune Thyroiditis.Cureus202642781218PubTator, text miningPubMed
Metabolic heterogeneity at the onset of type 2 diabetes: phenotypes of insulin resistance and β-cell function in the Kazakh population.Front Endocrinol (Lausanne)202642712388PubTator, text miningPubMed
Diabetic ketoacidosis associated with pancreatic involvement in a patient with von Hippel-Lindau syndrome: a case report.Front Endocrinol (Lausanne)202642609681PubTator, text miningPubMed
Type 1 Diabetes-Associated Autoantibodies, Sera and T-Cell Receptor Sequences Recognize Myelin Basic Protein: A Novel Peripheral Diabetic Neuropathy-Multiple Sclerosis Connection.Cells202642587793PubTator, text miningPubMed
Predictive Autoantibodies Before the Diagnosis of Type I Diabetes in Adults.medRxiv202642523204PubTator, text miningPubMed
Immune checkpoint inhibitor-induced diabetes mellitus: A case series from a large tertiary centre in the UK.Diabet Med202642522053PubTator, text miningPubMed
Impact of Autoimmune Hypothyroidism and Celiac Disease on Progression to Diabetes in Individuals Positive for GAD65 or IA-2 Autoantibodies.Diabetes Obes Metab202642373533PubTator, text miningPubMed

1 to 10 of 3,241

See all 3,241 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5798

GET https://conductscience.org/api/genes/v1/5798/patents?page=2