Gene · 5798
PTPRN: protein tyrosine phosphatase receptor type N
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PTPRN: protein tyrosine phosphatase receptor type N. Genes, record 5798. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5798
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16849 | Receptor-type tyrosine-protein phosphatase-like N | 979 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents238
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4698223 A2 | 2026-02-25 | 19 | Q16849 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60168 | Q16849 | Espacenet |
| US 12502436 B2 | 2025-12-23 | 2028 | Q16849 | Espacenet |
| US 12502436 B2 | 2025-12-23 | 2074 | Q16849 | Espacenet |
| US 12502436 B2 | 2025-12-23 | 2198 | Q16849 | Espacenet |
| US 12502436 B2 | 2025-12-23 | 2260 | Q16849 | Espacenet |
| US 12502436 B2 | 2025-12-23 | 2488 | Q16849 | Espacenet |
| JP 2025181835 A | 2025-12-11 | 2028 | Q16849 | Espacenet |
| JP 2025181835 A | 2025-12-11 | 2074 | Q16849 | Espacenet |
| JP 2025181835 A | 2025-12-11 | 2198 | Q16849 | Espacenet |
1 to 10 of 238
See all 238 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,442
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PTPRN papers | Newest fiscal year |
|---|---|---|---|
| R01DK032083 | Multiple Autoantigens, Multiple Epitopes of Type 1 Diabetes | 68 | 2025 |
| P30DK017047 | Diabetes Research Center | 40 | 2025 |
| P30DK116073 | University of Colorado Anschutz Medical Campus DRC | 24 | 2025 |
| P01AI042288 | Immune Function and the Progression to Type 1 Diabetes | 22 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 19 | 2025 |
| U01DK103282 | Type 1 Diabetes TrialNet Clinical Network Hub | 18 | 2025 |
| R01DK057846 | Modulating pathogenic T cells in Type 1 diabetes | 15 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 15 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 14 | 2025 |
| P30DK097512 | Indiana Diabetes Research Center | 14 | 2025 |
1 to 10 of 1,442Source NIH's project files
See all 1,442 nih grantsPapers3,241
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Performance assessment of a novel fully automated ELISA for anti-IA2 autoantibody detection in type 1 diabetes. | Clin Chim Acta | 2026 | 42822623 | PubTator, text mining | PubMed |
| Neurexin mediates neuropeptide release from cholinergic motor neurons through dense-core vesicle localization. | bioRxiv | 2026 | 42818522 | PubTator, text mining | PubMed |
| Single Autoantibody Positivity in Pediatric Type 1 Diabetes: Serological Profiles, Clinical Trajectories and Implications for Early Disease Monitoring-A Case Series of Seven Patients. | Life (Basel) | 2026 | 42795365 | PubTator, text mining | PubMed |
| A Case of Dual Endocrinopathies Induced by Pembrolizumab Following Treatment for Non-small Cell Lung Cancer: Type 1 Diabetes and Hyperthyroidism/Autoimmune Thyroiditis. | Cureus | 2026 | 42781218 | PubTator, text mining | PubMed |
| Metabolic heterogeneity at the onset of type 2 diabetes: phenotypes of insulin resistance and β-cell function in the Kazakh population. | Front Endocrinol (Lausanne) | 2026 | 42712388 | PubTator, text mining | PubMed |
| Diabetic ketoacidosis associated with pancreatic involvement in a patient with von Hippel-Lindau syndrome: a case report. | Front Endocrinol (Lausanne) | 2026 | 42609681 | PubTator, text mining | PubMed |
| Type 1 Diabetes-Associated Autoantibodies, Sera and T-Cell Receptor Sequences Recognize Myelin Basic Protein: A Novel Peripheral Diabetic Neuropathy-Multiple Sclerosis Connection. | Cells | 2026 | 42587793 | PubTator, text mining | PubMed |
| Predictive Autoantibodies Before the Diagnosis of Type I Diabetes in Adults. | medRxiv | 2026 | 42523204 | PubTator, text mining | PubMed |
| Immune checkpoint inhibitor-induced diabetes mellitus: A case series from a large tertiary centre in the UK. | Diabet Med | 2026 | 42522053 | PubTator, text mining | PubMed |
| Impact of Autoimmune Hypothyroidism and Celiac Disease on Progression to Diabetes in Individuals Positive for GAD65 or IA-2 Autoantibodies. | Diabetes Obes Metab | 2026 | 42373533 | PubTator, text mining | PubMed |
1 to 10 of 3,241
See all 3,241 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5798
GET https://conductscience.org/api/genes/v1/5798/patents?page=2