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Gene · 5810

RAD1: RAD1 checkpoint DNA exonuclease

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RAD1: RAD1 checkpoint DNA exonuclease. Genes, record 5810. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5810

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Gene

Symbol
RAD1
HGNC
Name
RAD1 checkpoint DNA exonuclease
HGNC
NCBI Gene ID
5810
NCBI Gene
HGNC ID
HGNC:9806
HGNC
Ensembl
ENSG00000113456
NCBI Gene
Aliases
HRAD1, REC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60671Cell cycle checkpoint protein RAD12827Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196586O60671Espacenet
JP 2025521592 A2025-07-1072O60671Espacenet
JP 2025517970 A2025-06-126586O60671Espacenet
JP 2025038035 A2025-03-184417O60671Espacenet
KR 1020250028392 A2025-02-2872O60671Espacenet
US 12134655 B22024-11-054417O60671Espacenet
JP 2024123008 A2024-09-107984O60671Espacenet
JP 2024123008 A2024-09-107985O60671Espacenet
US 11712440 B22023-08-0122O60671Espacenet
US 11446398 B22022-09-2071000O60671Espacenet

1 to 10 of 52

See all 52 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,049

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRAD1 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines132025
P30CA016672Cancer Center Support Grant112025
R01GM058015Recombinational Mechanisms of DNA Repair92025
R01CA093729Repair of Genome Destabilizing DNA Structures72025
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs72025
P30CA008748Cancer Center Support Grant62025
R01CA067985DNA Damage Repair by MUTYH and MUTYH Variants Associated with Colorectal Cancer52025
R01CA073764FEN1-mediated Okazaki fragment maturation and its deficiency in cancer52025
T32CA009582Biochemical and Chemical Training for Cancer Research52025
T32ES007059Advanced Training in Environmental Health Sciences52025

1 to 10 of 1,049Source NIH's project files

See all 1,049 nih grants

Papers1,299

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Rad1-Rad10 uses different interfaces to interact with pathway-specific DNA repair factors.Nucleic Acids Res202642745665PubTator, text miningPubMed
Collagen turnover biomarkers as diagnostic, prognostic, and therapy monitoring indicators in gastric cancer.Cancer Biomark202642627091PubTator, text miningPubMed
Mechanistic diversity of clamp loading at small DNA gaps.J Biol Chem202642575442PubTator, text miningPubMed
CTPS1 is an unexplored vulnerability in breast and ovarian cancer.Theranostics202642559234PubTator, text miningPubMed
Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity.Nat Struct Mol Biol202642380617PubTator, text miningPubMed
RAD1 promotes oxaliplatin resistance in gastric cancer by reinforcing NRF2-driven antioxidant defense and DDR checkpoint signaling.Drug Resist Updat202642217457PubTator, text miningPubMed
Construction of a novel signature based on CRISPR-Cas9 screening for prognostic prediction in breast cancer.BMC Cancer202642135732PubTator, text miningPubMed
Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities.J Biomed Sci202641928257PubTator, text miningPubMed
An updated view on lagging strand DNA replication: implications for the replication stress response.Cell Cycle202641865289PubTator, text miningPubMed
TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size.Nat Immunol202641862649PubTator, text miningPubMed

1 to 10 of 1,299

See all 1,299 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5810

GET https://conductscience.org/api/genes/v1/5810/patents?page=2