Gene · 5810
RAD1: RAD1 checkpoint DNA exonuclease
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RAD1: RAD1 checkpoint DNA exonuclease. Genes, record 5810. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5810
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O60671 | Cell cycle checkpoint protein RAD1 | 282 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents52
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 6586 | O60671 | Espacenet |
| JP 2025521592 A | 2025-07-10 | 72 | O60671 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6586 | O60671 | Espacenet |
| JP 2025038035 A | 2025-03-18 | 4417 | O60671 | Espacenet |
| KR 1020250028392 A | 2025-02-28 | 72 | O60671 | Espacenet |
| US 12134655 B2 | 2024-11-05 | 4417 | O60671 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7984 | O60671 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7985 | O60671 | Espacenet |
| US 11712440 B2 | 2023-08-01 | 22 | O60671 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 71000 | O60671 | Espacenet |
1 to 10 of 52
See all 52 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,049
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RAD1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| R01GM058015 | Recombinational Mechanisms of DNA Repair | 9 | 2025 |
| R01CA093729 | Repair of Genome Destabilizing DNA Structures | 7 | 2025 |
| ZIABC006150 | DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| R01CA067985 | DNA Damage Repair by MUTYH and MUTYH Variants Associated with Colorectal Cancer | 5 | 2025 |
| R01CA073764 | FEN1-mediated Okazaki fragment maturation and its deficiency in cancer | 5 | 2025 |
| T32CA009582 | Biochemical and Chemical Training for Cancer Research | 5 | 2025 |
| T32ES007059 | Advanced Training in Environmental Health Sciences | 5 | 2025 |
1 to 10 of 1,049Source NIH's project files
See all 1,049 nih grantsPapers1,299
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Rad1-Rad10 uses different interfaces to interact with pathway-specific DNA repair factors. | Nucleic Acids Res | 2026 | 42745665 | PubTator, text mining | PubMed |
| Collagen turnover biomarkers as diagnostic, prognostic, and therapy monitoring indicators in gastric cancer. | Cancer Biomark | 2026 | 42627091 | PubTator, text mining | PubMed |
| Mechanistic diversity of clamp loading at small DNA gaps. | J Biol Chem | 2026 | 42575442 | PubTator, text mining | PubMed |
| CTPS1 is an unexplored vulnerability in breast and ovarian cancer. | Theranostics | 2026 | 42559234 | PubTator, text mining | PubMed |
| Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity. | Nat Struct Mol Biol | 2026 | 42380617 | PubTator, text mining | PubMed |
| RAD1 promotes oxaliplatin resistance in gastric cancer by reinforcing NRF2-driven antioxidant defense and DDR checkpoint signaling. | Drug Resist Updat | 2026 | 42217457 | PubTator, text mining | PubMed |
| Construction of a novel signature based on CRISPR-Cas9 screening for prognostic prediction in breast cancer. | BMC Cancer | 2026 | 42135732 | PubTator, text mining | PubMed |
| Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities. | J Biomed Sci | 2026 | 41928257 | PubTator, text mining | PubMed |
| An updated view on lagging strand DNA replication: implications for the replication stress response. | Cell Cycle | 2026 | 41865289 | PubTator, text mining | PubMed |
| TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size. | Nat Immunol | 2026 | 41862649 | PubTator, text mining | PubMed |
1 to 10 of 1,299
See all 1,299 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5810
GET https://conductscience.org/api/genes/v1/5810/patents?page=2