Gene · 586
BCAT1: branched chain amino acid transaminase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BCAT1: branched chain amino acid transaminase 1. Genes, record 586. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/586
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P54687 | Branched-chain-amino-acid aminotransferase, cytosolic | 386 | 17 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 39123 | P54687 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1854 | P54687 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1433 | P54687 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4515 | P54687 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1433 | P54687 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1854 | P54687 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 9477 | P54687 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4515 | P54687 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 9477 | P54687 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 112448 | P54687 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants876
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BCAT1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 3 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 3 | 2025 |
| R01DK098263 | The Roles of Lipid Metabolism in the Maintenance of Hematopoietic Stem Cells | 3 | 2025 |
| U01CA206110 | Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare Study | 3 | 2025 |
| P20GM121288 | Center for Translational Viral Oncology (CTVO) | 2 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 2 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 876Source NIH's project files
See all 876 nih grantsPapers1,410
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| MTAP loss upregulates BCAT1 in pancreatic cancer and drives branched-chain amino acid dependency. | Cell Rep | 2026 | 42814576 | PubTator, text mining | PubMed |
| Identification of key genes and mechanistic exploration of metabolic reprogramming in osteoporosis. | J Int Med Res | 2026 | 42805907 | PubTator, text mining | PubMed |
| A stromal metabolic program suppresses NK-cell immunity to drive tumor progression in HER2-low breast cancer. | bioRxiv | 2026 | 42779696 | PubTator, text mining | PubMed |
| Fueling fibrosis: BCAT1 links branched-chain amino acid metabolism to collagen production. | J Clin Invest | 2026 | 42677840 | PubTator, text mining | PubMed |
| Astragaloside IV suppresses triple-negative breast cancer cell migration and invasion by targeting BCAT1-mediated branched-chain amino acid metabolism. | Oncol Lett | 2026 | 42598019 | PubTator, text mining | PubMed |
| Tape-strip transcriptomics identify immune signatures in cutaneous T-cell lymphoma distinct from benign inflammatory skin diseases. | J Allergy Clin Immunol | 2026 | 42567485 | PubTator, text mining | PubMed |
| Environmental pollutants and testicular toxicity in male reproductive health: Basic evidence and translational prospects - A narrative review. | Reprod Toxicol | 2026 | 42551576 | PubTator, text mining | PubMed |
| A pan-cancer analysis of the oncogenic role of branched-chain aminotransferase 1 (BCAT1) in human tumors. | Medicine (Baltimore) | 2026 | 42536572 | PubTator, text mining | PubMed |
| Crystal structure of the phosphomimetic variant of the brain-specific cytosolic branched chain aminotransferase. | J Biomol Struct Dyn | 2026 | 42520105 | PubTator, text mining | PubMed |
| Prospective evaluation of a multi-gene cfDNA methylation assay for colorectal cancer screening in a high-risk cohort. | Clin Chem Lab Med | 2026 | 42517221 | PubTator, text mining | PubMed |
1 to 10 of 1,410
See all 1,410 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/586
GET https://conductscience.org/api/genes/v1/586/patents?page=2