ConductScience.org, home

Gene · 586

BCAT1: branched chain amino acid transaminase 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. BCAT1: branched chain amino acid transaminase 1. Genes, record 586. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/586

On this page

Gene

Symbol
BCAT1
HGNC
Name
branched chain amino acid transaminase 1
HGNC
NCBI Gene ID
586
NCBI Gene
HGNC ID
HGNC:976
HGNC
Ensembl
ENSG00000060982
NCBI Gene
Aliases
BCATC, BCATc, BCT1, ECA39, MECA39, PNAS121, PP18
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54687Branched-chain-amino-acid aminotransferase, cytosolic38617Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439123P54687Espacenet
EP 4650780 A22025-11-191854P54687Espacenet
EP 4641201 A22025-10-291433P54687Espacenet
EP 4641202 A22025-10-294515P54687Espacenet
JP 2025517969 A2025-06-121433P54687Espacenet
JP 2025517970 A2025-06-121854P54687Espacenet
JP 2025062604 A2025-04-149477P54687Espacenet
KR 1020250017231 A2025-02-044515P54687Espacenet
US 11446398 B22022-09-209477P54687Espacenet
JP 2022524081 A2022-04-27112448P54687Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants876

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBCAT1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant52025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA016087Cancer Center Support Grant32025
P40OD010440Caenorhabditis Genetics Center32025
R01DK098263The Roles of Lipid Metabolism in the Maintenance of Hematopoietic Stem Cells32025
U01CA206110Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare Study32025
P20GM121288Center for Translational Viral Oncology (CTVO)22025
P30CA014051Cancer Center Support (Core) Grant22025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025

1 to 10 of 876Source NIH's project files

See all 876 nih grants

Papers1,410

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MTAP loss upregulates BCAT1 in pancreatic cancer and drives branched-chain amino acid dependency.Cell Rep202642814576PubTator, text miningPubMed
Identification of key genes and mechanistic exploration of metabolic reprogramming in osteoporosis.J Int Med Res202642805907PubTator, text miningPubMed
A stromal metabolic program suppresses NK-cell immunity to drive tumor progression in HER2-low breast cancer.bioRxiv202642779696PubTator, text miningPubMed
Fueling fibrosis: BCAT1 links branched-chain amino acid metabolism to collagen production.J Clin Invest202642677840PubTator, text miningPubMed
Astragaloside IV suppresses triple-negative breast cancer cell migration and invasion by targeting BCAT1-mediated branched-chain amino acid metabolism.Oncol Lett202642598019PubTator, text miningPubMed
Tape-strip transcriptomics identify immune signatures in cutaneous T-cell lymphoma distinct from benign inflammatory skin diseases.J Allergy Clin Immunol202642567485PubTator, text miningPubMed
Environmental pollutants and testicular toxicity in male reproductive health: Basic evidence and translational prospects - A narrative review.Reprod Toxicol202642551576PubTator, text miningPubMed
A pan-cancer analysis of the oncogenic role of branched-chain aminotransferase 1 (BCAT1) in human tumors.Medicine (Baltimore)202642536572PubTator, text miningPubMed
Crystal structure of the phosphomimetic variant of the brain-specific cytosolic branched chain aminotransferase.J Biomol Struct Dyn202642520105PubTator, text miningPubMed
Prospective evaluation of a multi-gene cfDNA methylation assay for colorectal cancer screening in a high-risk cohort.Clin Chem Lab Med202642517221PubTator, text miningPubMed

1 to 10 of 1,410

See all 1,410 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/586

GET https://conductscience.org/api/genes/v1/586/patents?page=2