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Gene · 5873

RAB27A: RAB27A, member RAS oncogene family

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RAB27A: RAB27A, member RAS oncogene family. Genes, record 5873. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5873

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Gene

Symbol
RAB27A
HGNC
Name
RAB27A, member RAS oncogene family
HGNC
NCBI Gene ID
5873
NCBI Gene
HGNC ID
HGNC:9766
HGNC
Ensembl
ENSG00000069974
NCBI Gene
Aliases
GS2, HsT18676, RAB27, RAM
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51159Ras-related protein Rab-27A22111Ensembl, GeneID, HGNC

Source UniProt

Patents99

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460675P51159Espacenet
JP 2026004568 A2026-01-1460677P51159Espacenet
EP 4650780 A22025-11-196307P51159Espacenet
EP 4641201 A22025-10-296064P51159Espacenet
JP 2025517969 A2025-06-126064P51159Espacenet
JP 2025517970 A2025-06-126307P51159Espacenet
JP 2025032204 A2025-03-1134476P51159Espacenet
JP 2025032204 A2025-03-1134477P51159Espacenet
JP 2025032204 A2025-03-1134478P51159Espacenet
JP 2025032204 A2025-03-1134484P51159Espacenet

1 to 10 of 99

See all 99 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,968

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRAB27A papersNewest fiscal year
R01HL088256Vesicular trafficking mechanisms regulating granulocyte function152025
ZIAHG000215Human Biochemical Genetics132025
P30CA016672Cancer Center Support Grant92025
P30DK020572Michigan Diabetes Research Center (MDRC)82025
R01EY015625Hermansky-Pudlak syndrome and melanosome formation82025
P30DK058404Molecular and Cellular Basis for Digestive Diseases72025
P30CA016086Cancer Center Support Grant62025
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment52025
P30CA010815Consolidated Basic Cancer Research Program52025
P30CA068485Cancer Center Support Grant52025

1 to 10 of 1,968Source NIH's project files

See all 1,968 nih grants

Papers3,592

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence.Aging Cell202642775649PubTator, text miningPubMed
The AHR-TFAP2A axis regulates melanosome transport by directly targeting myosin Va and Mlph.J Invest Dermatol202642754141PubTator, text miningPubMed
HDCA suppresses exosomal lncRNA MSTRG171708 release to inhibit Treg-mediated immunometabolism in hepatocellular carcinoma.Mol Biomed202642726156PubTator, text miningPubMed
miR-27b-5p targets RAB27A to regulate exosome secretion and migration of pancreatic cancer cells.Transl Cancer Res202642724932PubTator, text miningPubMed
SARS-CoV-2 SUD2core promotes neutrophil-mediated inflammation by disabling HEBP2-mediated restraint on granule exocytosis.Cell Rep202642690932PubTator, text miningPubMed
Lipid-manager autophagy proteins ATG2 and ATG9 regulate extracellular vesicle secretion via amphisome biogenesis and cell lipidome modulation.Nat Commun202642637773PubTator, text miningPubMed
Modulating immune toxicity in ulcerative colitis using a small molecule RAB27A inhibitor.Inflamm Bowel Dis202642627211PubTator, text miningPubMed
Endothelial PIEZO1 regulates Weibel-Palade body exocytosis.Blood202642611778PubTator, text miningPubMed
Exosomes mediate intercellular transmission of Tembusu virus via the NS4A-Rab27a axis.Vet Res202642572027PubTator, text miningPubMed
X-linked SYTL4 missense variant disrupts RAB27A-dependent vesicle trafficking and synaptic transmission in autism.Proc Natl Acad Sci U S A202642531028PubTator, text miningPubMed

1 to 10 of 3,592

See all 3,592 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5873

GET https://conductscience.org/api/genes/v1/5873/patents?page=2