Gene · 5873
RAB27A: RAB27A, member RAS oncogene family
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RAB27A: RAB27A, member RAS oncogene family. Genes, record 5873. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5873
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P51159 | Ras-related protein Rab-27A | 221 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents99
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 60675 | P51159 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60677 | P51159 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6307 | P51159 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6064 | P51159 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6064 | P51159 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6307 | P51159 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34476 | P51159 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34477 | P51159 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34478 | P51159 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 34484 | P51159 | Espacenet |
1 to 10 of 99
See all 99 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,968
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RAB27A papers | Newest fiscal year |
|---|---|---|---|
| R01HL088256 | Vesicular trafficking mechanisms regulating granulocyte function | 15 | 2025 |
| ZIAHG000215 | Human Biochemical Genetics | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 8 | 2025 |
| R01EY015625 | Hermansky-Pudlak syndrome and melanosome formation | 8 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 7 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
| P01CA163222 | Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment | 5 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 1,968Source NIH's project files
See all 1,968 nih grantsPapers3,592
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence. | Aging Cell | 2026 | 42775649 | PubTator, text mining | PubMed |
| The AHR-TFAP2A axis regulates melanosome transport by directly targeting myosin Va and Mlph. | J Invest Dermatol | 2026 | 42754141 | PubTator, text mining | PubMed |
| HDCA suppresses exosomal lncRNA MSTRG171708 release to inhibit Treg-mediated immunometabolism in hepatocellular carcinoma. | Mol Biomed | 2026 | 42726156 | PubTator, text mining | PubMed |
| miR-27b-5p targets RAB27A to regulate exosome secretion and migration of pancreatic cancer cells. | Transl Cancer Res | 2026 | 42724932 | PubTator, text mining | PubMed |
| SARS-CoV-2 SUD2core promotes neutrophil-mediated inflammation by disabling HEBP2-mediated restraint on granule exocytosis. | Cell Rep | 2026 | 42690932 | PubTator, text mining | PubMed |
| Lipid-manager autophagy proteins ATG2 and ATG9 regulate extracellular vesicle secretion via amphisome biogenesis and cell lipidome modulation. | Nat Commun | 2026 | 42637773 | PubTator, text mining | PubMed |
| Modulating immune toxicity in ulcerative colitis using a small molecule RAB27A inhibitor. | Inflamm Bowel Dis | 2026 | 42627211 | PubTator, text mining | PubMed |
| Endothelial PIEZO1 regulates Weibel-Palade body exocytosis. | Blood | 2026 | 42611778 | PubTator, text mining | PubMed |
| Exosomes mediate intercellular transmission of Tembusu virus via the NS4A-Rab27a axis. | Vet Res | 2026 | 42572027 | PubTator, text mining | PubMed |
| X-linked SYTL4 missense variant disrupts RAB27A-dependent vesicle trafficking and synaptic transmission in autism. | Proc Natl Acad Sci U S A | 2026 | 42531028 | PubTator, text mining | PubMed |
1 to 10 of 3,592
See all 3,592 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5873
GET https://conductscience.org/api/genes/v1/5873/patents?page=2