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Gene · 5874

RAB27B: RAB27B, member RAS oncogene family

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RAB27B: RAB27B, member RAS oncogene family. Genes, record 5874. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5874

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Gene

Symbol
RAB27B
HGNC
Name
RAB27B, member RAS oncogene family
HGNC
NCBI Gene ID
5874
NCBI Gene
HGNC ID
HGNC:9767
HGNC
Ensembl
ENSG00000041353
NCBI Gene
Aliases
C25KG
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00194Ras-related protein Rab-27B2181Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025032204 A2025-03-1134486O00194Espacenet
EP 4484957 A12025-01-0172O00194Espacenet
EP 4461818 A22024-11-1334486O00194Espacenet
WO 2023162878 A2023-08-3172O00194Espacenet
JP 2023058610 A2023-04-2534486O00194Espacenet
US 11446378 B22022-09-207O00194Espacenet
US 11446398 B22022-09-2070660O00194Espacenet
JP 2022532497 A2022-07-1539O00194Espacenet
JP 2022524081 A2022-04-27173631O00194Espacenet
US 11078247 B22021-08-039258O00194Espacenet

1 to 10 of 34

See all 34 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants863

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRAB27B papersNewest fiscal year
T32ES007326Interdisciplinary Research Training Program in Environmental Health and Toxicology62025
T32ES018827Research Training in Environmental Toxicology62025
R01NS125016Engineering Extracellular Vesicles of Human Brain Organoids for Stroke Therapy42025
ZIAHG000215Human Biochemical Genetics42025
P30CA016672Cancer Center Support Grant32025
P30CA225520Stephenson Cancer Center - Cancer Center Support Grant32025
R01EY011386Microtubule-based Transport in Lacrimal Gland Function32025
IK4BX005219BLR&D Research Career Development Transition Award Application22025
K12DK100024Duke KURe Program22025
P30AG066511Goizueta Alzheimer's Disease Research Center22025

1 to 10 of 863Source NIH's project files

See all 863 nih grants

Papers1,324

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of a shared blood-brain transcriptomic signature in Parkinson's disease using bioinformatic and network pharmacology approaches.Neuroscience202642826760PubTator, text miningPubMed
Heat-preconditioned MSC-derived exosomal miR‑486‑5p reverses doxorubicin resistance in breast cancer.Nanomedicine (Lond)202642821374PubTator, text miningPubMed
Cross-tissue Mendelian randomization prioritizes RAB27B as a brain-derived candidate protein for postpartum depression.Eur Arch Psychiatry Clin Neurosci202642584685PubTator, text miningPubMed
Cisplatin-Induced Rab27A/B Exosomal PD-L1 Axis Suppresses Antitumor Immunity and Correlates with Poor 5-Year Survival in Lung Squamous Cell Carcinoma and Adenocarcinoma.Curr Issues Mol Biol202642510937PubTator, text miningPubMed
Extracellular vesicle cargo dynamics in the bone marrow microenvironment: from hematopoietic homeostasis to malignant transformation.Extracell Vesicle202642344609PubTator, text miningPubMed
A TRPM4-associated necrotic cell death signature for prognostic stratification in pancreatic cancer.J Gastrointest Oncol202642169933PubTator, text miningPubMed
Rab27: Molecular switch of tumor exosome secretion (Review).Int J Mol Med202642138205PubTator, text miningPubMed
Rab27b: A Modulator of Lysosomal Function and Alpha-Synuclein Clearance in Parkinson's Disease.J Neurosci202642020315PubTator, text miningPubMed
Extracellular Vesicles Associated Metabolites as Intercellular Signalling Mediators in Disease and Therapy.Metabolites202641893356PubTator, text miningPubMed
Linking first-pass reperfusion success to proteomic markers in large and medium vessel ischemic stroke: an exploratory study.Precis Clin Med202641878235PubTator, text miningPubMed

1 to 10 of 1,324

See all 1,324 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5874

GET https://conductscience.org/api/genes/v1/5874/patents?page=2