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Gene · 5880

RAC2: Rac family small GTPase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RAC2: Rac family small GTPase 2. Genes, record 5880. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5880

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Gene

Symbol
RAC2
HGNC
Name
Rac family small GTPase 2
HGNC
NCBI Gene ID
5880
NCBI Gene
HGNC ID
HGNC:9802
HGNC
Ensembl
ENSG00000128340
NCBI Gene
Aliases
EN-7, Gx, HSPC022, IMD73A, IMD73B, IMD73C, p21-Rac2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P15153Ras-related C3 botulinum toxin substrate 21924Ensembl, GeneID, HGNC

Source UniProt

Patents72

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4801540 A12026-09-0976P15153Espacenet
WO 2026012976 A12026-01-151P15153Espacenet
EP 4661970 A12025-12-1762167P15153Espacenet
EP 4650780 A22025-11-191268P15153Espacenet
JP 2025517970 A2025-06-121268P15153Espacenet
JP 2025502257 A2025-01-241P15153Espacenet
WO 2024261302 A12024-12-261P15153Espacenet
JP 2024123008 A2024-09-108132P15153Espacenet
EP 4414002 A22024-08-141P15153Espacenet
JP 2023522933 A2023-06-011P15153Espacenet

1 to 10 of 72

See all 72 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,180

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRAC2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant122025
P30CA016086Cancer Center Support Grant82025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes62025
ZIAAI000646Transgenic Animal Models Of Human Immune Defects62025
ZIAAI000647Genes And Gene Products As Immunoadjuvants62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P30CA046934University of Colorado Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
P30CA118100University of New Mexico Cancer Center Support Grant42025

1 to 10 of 2,180Source NIH's project files

See all 2,180 nih grants

Papers3,143

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Human inborn errors of the phagocyte respiratory burst: Chronic granulomatous disease and beyond.J Hum Immun202642758005PubTator, text miningPubMed
Integration of transcriptomics and machine learning to explore inflammatory characteristics and key oxidative stress-related molecules in nasal polyps.Front Immunol202642718792PubTator, text miningPubMed
RAC2 orchestrates immune cell actin remodeling and migration.Front Immunol202642694400PubTator, text miningPubMed
Identification and validation of novel platelet-related genes in ulcerative colitis using bioinformatics and machine learning strategies.PeerJ202642668808PubTator, text miningPubMed
Bioinformatics analysis reveals shared gene signatures and molecular mechanisms between periodontitis and rheumatoid arthritis in the context of aging.Acta Odontol Scand202642627218PubTator, text miningPubMed
Investigating the Cellular Activity and Differential Gene Expression of Human Astrocytes in Interaction with Protein Composite Nanofibers.Neurochem Res202642599588PubTator, text miningPubMed
How Functional Variants Reconfigure the Rac2 Conformational Landscape.J Phys Chem B202642593131PubTator, text miningPubMed
Molecular Pathogenesis and Therapeutic Response of Diffuse Large B Cell Lymphoma Genetic Subtypes.Annu Rev Cancer Biol202642487683PubTator, text miningPubMed
Association Study of Wnt Pathway Genes with Non-syndromic Orofacial Cleft in Han Chinese.Cleft Palate Craniofac J202642412006PubTator, text miningPubMed
CD40LG/CD28-Mediated Rho GTPase Signaling Drives Survival and Chemoresistance in Non-ETP T-ALL.Int J Mol Sci202642353028PubTator, text miningPubMed

1 to 10 of 3,143

See all 3,143 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5880

GET https://conductscience.org/api/genes/v1/5880/patents?page=2