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Gene · 5889

RAD51C: RAD51 paralog C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RAD51C: RAD51 paralog C. Genes, record 5889. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5889

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Gene

Symbol
RAD51C
HGNC
Name
RAD51 paralog C
HGNC
NCBI Gene ID
5889
NCBI Gene
HGNC ID
HGNC:9820
HGNC
Ensembl
ENSG00000108384
NCBI Gene
Aliases
BROVCA3, FANCO, R51H3, RAD51L2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43502DNA repair protein RAD51 homolog 337617Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-295973O43502Espacenet
JP 2025517969 A2025-06-125973O43502Espacenet
JP 2024123008 A2024-09-108031O43502Espacenet
US 11597924 B22023-03-0771O43502Espacenet
US 11446398 B22022-09-2071101O43502Espacenet
JP 2022524081 A2022-04-27174072O43502Espacenet
US 10501513 B22019-12-108031O43502Espacenet
US 10207988 B22019-02-19164O43502Espacenet
JP 2017197545 A2017-11-0232732O43502Espacenet
US 9587003 B22017-03-078031O43502Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,650

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRAD51C papersNewest fiscal year
P30CA008748Cancer Center Support Grant852025
P30CA016672Cancer Center Support Grant502025
P50CA116201Mayo Clinic Breast Cancer SPORE272025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant232025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer202025
P01CA092584Structural Cell Biology of DNA Repair Machines172025
P30CA006973Regional Oncology Research Center172025
P30CA033572Cancer Center Support Grant142025
P30CA015704Cancer Center Support Grant122025
P30CA016056Roswell Park Cancer Center Support Grant122025

1 to 10 of 1,650Source NIH's project files

See all 1,650 nih grants

Papers3,668

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Prevalence of pathogenic germline variants and indications for testing in a diverse community-based endometrial cancer cohort.Gynecol Oncol202642822083PubTator, text miningPubMed
Genome-Wide CRISPR Screens Identify Genome Stability as Regulator of the Cellular Sensitivity to Environmentally Relevant Bisphenol A Exposure.Biomolecules202642793135PubTator, text miningPubMed
Breast-Ovarian Hereditary Cancer Syndrome: Beyond BRCA1 and BRCA2.Curr Oncol202642782902PubTator, text miningPubMed
SCRMP-mediated SUMOylation of CSNK2B facilitates DNA damage repair to promote cisplatin resistance in small cell lung cancer.Sci Transl Med202642777084PubTator, text miningPubMed
Potential of RAD51C as a hub gene and therapeutic target in bladder cancer: insights from bioinformatics and experimental analysis.Int J Surg202642682403PubTator, text miningPubMed
Distinct functions of mammalian RAD51 paralogs in genome maintenance.Biochem Soc Trans202642682019PubTator, text miningPubMed
Risk-reducing gynecologic surgery in non-BRCA cancer predisposition mutations: a multi-institutional study.Int J Gynecol Cancer202642648957PubTator, text miningPubMed
RAD51C breast cancer-identified variants with attenuated homologous recombination function exhibit sensitivity to combined PARP1 and ATR inhibition.NAR Cancer202642625895PubTator, text miningPubMed
From genetic testing to prevention: an integrated clinical pathway for hereditary risk assessment in tubo-ovarian cancer.Int J Gynecol Cancer202642617415PubTator, text miningPubMed
Uncovering Hereditary Risk: Germline Homologous Recombination Repair Variant Spectrum in a Large North Indian Cancer Cohort (INSIGHT-HRR).JCO Glob Oncol202642594331PubTator, text miningPubMed

1 to 10 of 3,668

See all 3,668 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5889

GET https://conductscience.org/api/genes/v1/5889/patents?page=2