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RAF1: Raf-1 proto-oncogene, serine/threonine kinase

1 protein, 106 patents, 12 drugs, 886 trials, 8,894 NIH grants and 20,861 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRAF1HGNC
NameRaf-1 proto-oncogene, serine/threonine kinaseHGNC
NCBI Gene ID5894NCBI Gene
HGNC IDHGNC:9829HGNC
EnsemblENSG00000132155NCBI Gene
AliasesCMD1NN, CRAF, NS5, Raf-1, c-RafNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04049RAF proto-oncogene serine/threonine-protein kinase64876Ensembl, GeneID, HGNCUniProt

Patents 106

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4828624 A12026-10-281P04049Espacenet
WO 2025262045 A12025-12-269P04049Espacenet
EP 4650780 A22025-11-191360P04049Espacenet
EP 4641201 A22025-10-29988P04049Espacenet
JP 2025517969 A2025-06-12988P04049Espacenet
JP 2025517970 A2025-06-121360P04049Espacenet
US 12146196 B22024-11-192P04049Espacenet
JP 2024123008 A2024-09-109032P04049Espacenet
US 11920164 B22024-03-05194P04049Espacenet
US 11884978 B22024-01-30699P04049Espacenet

Drugs 12

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARQ-736CHEMBL5314407Serine/threonine-protein kinase RAF inhibitorINHIBITORChEMBL
ARQ-736 FREE ACIDCHEMBL5316167Serine/threonine-protein kinase RAF inhibitorINHIBITORChEMBL
BELVARAFENIBCHEMBL3977543RAF serine/threonine protein kinase inhibitorINHIBITORChEMBL
LGX-806CHEMBL3545263Serine/threonine-protein kinase RAF inhibitorINHIBITORChEMBL
LY-3009120CHEMBL3577124Serine/threonine-protein kinase RAF inhibitorINHIBITORChEMBL
NAPORAFENIBCHEMBL4583691B-raf/RAF proto-oncogene serine/threonine-protein kinase inhibitorINHIBITORChEMBL
REGORAFENIBCHEMBL1946170Serine/threonine-protein kinase RAF inhibitorINHIBITORChEMBL
RG-7376CHEMBL3545082Serine/threonine-protein kinase RAF inhibitorINHIBITORChEMBL
SORAFENIBCHEMBL1336Serine/threonine-protein kinase RAF inhibitorINHIBITORChEMBL
SORAFENIB TOSYLATECHEMBL1200485Serine/threonine-protein kinase RAF inhibitorINHIBITORChEMBL

Trials 886

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572695SORAFENIBClinicalTrials.gov
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov
NCT07495579REGORAFENIBPHASE2ClinicalTrials.gov
NCT07463651SORAFENIBPHASE3ClinicalTrials.gov
NCT07463248SORAFENIBPHASE2ClinicalTrials.gov
NCT07463248REGORAFENIBPHASE2ClinicalTrials.gov

NIH grants 8894

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1932,025NIH's project files
P30CA016672Cancer Center Support Grant1712,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant452,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase342,025NIH's project files
P30CA006973Regional Oncology Research Center322,025NIH's project files
ZIASC010074HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction262,025NIH's project files
P30CA016058Cancer Center Support Grant242,025NIH's project files
R01AI087856MECHANISM OF RNA SYNTHESIS BY DENGUE VIRUS NS5232,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program222,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant222,025NIH's project files

Papers 20861

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826365PubTator, text miningPubMed
42820267PubTator, text miningPubMed
42818629PubTator, text miningPubMed
42801566PubTator, text miningPubMed
42797826PubTator, text miningPubMed
42796582PubTator, text miningPubMed
42795607PubTator, text miningPubMed
42781612PubTator, text miningPubMed
42781550PubTator, text miningPubMed
42773483PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license