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ACTA2: actin alpha 2, smooth muscle

1 protein, 111 patents, 0 drugs, 0 trials, 5,175 NIH grants and 8,845 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolACTA2HGNC
Nameactin alpha 2, smooth muscleHGNC
NCBI Gene ID59NCBI Gene
HGNC IDHGNC:130HGNC
EnsemblENSG00000107796NCBI Gene
AliasesACTSA, SMDYSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P62736Actin, aortic smooth muscle3770Ensembl, GeneID, HGNCUniProt

Patents 111

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19614P62736Espacenet
EP 4605079 A12025-08-271P62736Espacenet
JP 2025517970 A2025-06-12614P62736Espacenet
JP 2025062604 A2025-04-141499P62736Espacenet
JP 2025062604 A2025-04-141502P62736Espacenet
JP 2025013347 A2025-01-24112P62736Espacenet
US 12201675 B22025-01-21112P62736Espacenet
JP 2025003953 A2025-01-14112P62736Espacenet
KR 1020240162163 A2024-11-14112P62736Espacenet
KR 1020240151608 A2024-10-1820P62736Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5175

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
UL1TR001863Yale Clinical and Translational Science Award242,025NIH's project files
P30CA008748Cancer Center Support Grant232,025NIH's project files
P30CA016672Cancer Center Support Grant212,025NIH's project files
P30CA045508CSHL Cancer Center Support Grant122,025NIH's project files
R01HL092961Epithelial-Mesenchymal Interactions in Fibrosis Resolution122,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)112,025NIH's project files
T32HL007284Basic Cardiovascular Research Training Grant112,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital102,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center102,025NIH's project files
P50AA011999Southern California Research Center for ALPD and Cirrhosis102,025NIH's project files

Papers 8845

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818815PubTator, text miningPubMed
42779462PubTator, text miningPubMed
42765450PubTator, text miningPubMed
42743285PubTator, text miningPubMed
42737821PubTator, text miningPubMed
42729537PubTator, text miningPubMed
42711624PubTator, text miningPubMed
42692183PubTator, text miningPubMed
42691512PubTator, text miningPubMed
42689320PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license