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BCHE: butyrylcholinesterase

1 protein, 150 patents, 5 drugs, 55 trials, 3,108 NIH grants and 21,931 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolBCHEHGNC
NamebutyrylcholinesteraseHGNC
NCBI Gene ID590NCBI Gene
HGNC IDHGNC:983HGNC
EnsemblENSG00000114200NCBI Gene
AliasesBCHED, CHE1, CHE2, E1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P06276Cholinesterase602109Ensembl, GeneID, HGNCUniProt

Patents 150

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439406P06276Espacenet
EP 4641201 A22025-10-291913P06276Espacenet
JP 2025147176 A2025-10-061446P06276Espacenet
JP 2025529142 A2025-09-045582P06276Espacenet
US 12371689 B22025-07-295582P06276Espacenet
JP 2025517969 A2025-06-121913P06276Espacenet
JP 2025062604 A2025-04-1410172P06276Espacenet
JP 2025032204 A2025-03-1125120P06276Espacenet
JP 2025028160 A2025-02-281446P06276Espacenet
KR 1020250010750 A2025-01-211446P06276Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PROPANIDIDCHEMBL2105345Butyrylcholinesterase inhibitorINHIBITORChEMBL
RIVASTIGMINECHEMBL636Cholinesterases; ACHE & BCHE inhibitorINHIBITORChEMBL
RIVASTIGMINE TARTRATECHEMBL1201092Cholinesterases; ACHE & BCHE inhibitorINHIBITORChEMBL
TACRINECHEMBL95Cholinesterases; ACHE & BCHE inhibitorINHIBITORChEMBL
TACRINE HYDROCHLORIDECHEMBL1677Cholinesterases; ACHE & BCHE inhibitorINHIBITORChEMBL

Trials 55

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06828289RIVASTIGMINEClinicalTrials.gov
NCT06702124RIVASTIGMINEPHASE3ClinicalTrials.gov
NCT06382649RIVASTIGMINEPHASE2ClinicalTrials.gov
NCT05853341RIVASTIGMINEPHASE1ClinicalTrials.gov
NCT04366518RIVASTIGMINEEARLY_PHASE1ClinicalTrials.gov
NCT03840837RIVASTIGMINEPHASE4ClinicalTrials.gov
NCT03454646RIVASTIGMINEPHASE4ClinicalTrials.gov
NCT03250741RIVASTIGMINEPHASE2ClinicalTrials.gov
NCT02989402RIVASTIGMINEPHASE42024-05-31ClinicalTrials.gov
NCT02839642RIVASTIGMINEPHASE3ClinicalTrials.gov

NIH grants 3108

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA036727Buffett Cancer Center Support Grant782,025NIH's project files
ZIAAG000311ALZHEIMERS RESEARCH PROJECT: Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)472,025NIH's project files
P42ES010356Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation342,025NIH's project files
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment232,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)162,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)132,025NIH's project files
P30ES005605Environmental Health Sciences Research Center102,025NIH's project files
R01ES025792Cyclical Alterations In Neurocognitive Performance And Mood Over Two Years In Relation To Pesticide Spray Seasons Among Adolescent And Young Adult Participants Of The Espina Study.102,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)82,025NIH's project files
P20GM109025Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission72,025NIH's project files

Papers 21931

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827170PubTator, text miningPubMed
42824777PubTator, text miningPubMed
42822277PubTator, text miningPubMed
42820787PubTator, text miningPubMed
42810176PubTator, text miningPubMed
42805096PubTator, text miningPubMed
42801755PubTator, text miningPubMed
42801246PubTator, text miningPubMed
42800137PubTator, text miningPubMed
42798501PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license