ConductScience.org, home

Gene · 5905

RANGAP1: Ran GTPase activating protein 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. RANGAP1: Ran GTPase activating protein 1. Genes, record 5905. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5905

On this page

Gene

Symbol
RANGAP1
HGNC
Name
Ran GTPase activating protein 1
HGNC
NCBI Gene ID
5905
NCBI Gene
HGNC ID
HGNC:9854
HGNC
Ensembl
ENSG00000100401
NCBI Gene
Aliases
Fug1, KIAA1835, RANGAP, SD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P46060Ran GTPase-activating protein 158714Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-197266P46060Espacenet
EP 4641201 A22025-10-297211P46060Espacenet
JP 2025517969 A2025-06-127211P46060Espacenet
JP 2025517970 A2025-06-127266P46060Espacenet
JP 2024530931 A2024-08-2711P46060Espacenet
EP 4380580 A22024-06-1211P46060Espacenet
KR 1020240083171 A2024-06-1111P46060Espacenet
US 11564998 B22023-01-315895P46060Espacenet
US 11564998 B22023-01-317131P46060Espacenet
US 11564998 B22023-01-317134P46060Espacenet

1 to 10 of 71

See all 71 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,121

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRANGAP1 papersNewest fiscal year
R01NS027036Disease Mechanism and Therapy in TDP-43 Proteinopathies and Dementias72025
P30CA008748Cancer Center Support Grant62025
T32CA009110Training in Areas Fundamental to Cancer Research62025
P30CA016672Cancer Center Support Grant52025
P30CA021765Cancer Center Support Grant (CCSG)42025
P30CA033572Cancer Center Support Grant42025
R01GM117360Molecular Basis of mRNA Export42025
ZIAHD008954Mitotic roles of the Nuclear Transport Machinery42025
P30CA042014Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025

1 to 10 of 1,121Source NIH's project files

See all 1,121 nih grants

Papers1,466

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated Transcriptomic Analysis Identifies Potential Biomarkers in Castration-Resistant Prostate Cancer.World J Oncol202642490773PubTator, text miningPubMed
The structural basis of RanGAP1 regulation and catalysis in nuclear transport.bioRxiv202642388800PubTator, text miningPubMed
Identification and Validation of Mitophagy-Related Biomarkers in Colorectal Cancer: An Integrated Analysis of Single-Cell Transcriptome and Mendelian Randomization.Genet Res (Camb)202642108926PubTator, text miningPubMed
TMEM106B C-terminal fragments drive nucleocytoplasmic transport failure and TDP-43 mislocalization in the aging human brain.bioRxiv202642094412PubTator, text miningPubMed
RanGAP1 plays a vital role in anti-infective functions of macrophages and sepsis progression.Immunol Lett202642055254PubTator, text miningPubMed
GAP mimetic activity of pan-Ras TCI daraxonrasib synergizes with K-Ras Switch-II pocket inhibition.Biol Chem202642030031PubTator, text miningPubMed
RanGAP1 accumulates in stress-induced cytoplasmic compartments that are distinct from stress granules and P-bodies.MicroPubl Biol202641924656PubTator, text miningPubMed
Temporal dynamics and functional annotation of transcriptome rhythmicity in HEK293T cells.PLoS One202641746989PubTator, text miningPubMed
Impaired nucleocytoplasmic transport in SOD1-mediated ALS.Mol Neurodegener202641691309PubTator, text miningPubMed
Engineering an orthogonal ubiquitin transfer cascade with RING E3 RNF38 by phage display to reveal its regulation of nuclear transport.J Biol Chem202641581872PubTator, text miningPubMed

1 to 10 of 1,466

See all 1,466 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5905

GET https://conductscience.org/api/genes/v1/5905/patents?page=2