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IL21: interleukin 21

1 protein, 400 patents, 1 drug, 5 trials, 7,560 NIH grants and 16,169 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL21HGNC
Nameinterleukin 21HGNC
NCBI Gene ID59067NCBI Gene
HGNC IDHGNC:6005HGNC
EnsemblENSG00000138684NCBI Gene
AliasesCVID11, IL-21, Za11NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9HBE4Interleukin-211623Ensembl, GeneID, HGNCUniProt

Patents 400

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4806919 A12026-09-1622Q9HBE4Espacenet
EP 4795154 A12026-08-26133Q9HBE4Espacenet
EP 4795155 A12026-08-2631Q9HBE4Espacenet
EP 4791437 A12026-08-19172Q9HBE4Espacenet
EP 4773980 A12026-07-1514Q9HBE4Espacenet
EP 4752223 A22026-06-033Q9HBE4Espacenet
JP 2026082951 A2026-05-1915Q9HBE4Espacenet
JP 2026516046 A2026-05-19185Q9HBE4Espacenet
JP 2026516052 A2026-05-19185Q9HBE4Espacenet
JP 2026513839 A2026-05-01521Q9HBE4Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
NNC0114-0006CHEMBL4297797Interleukin-21 binding agentBINDING AGENTChEMBL

Trials 5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02443155NNC0114-0006PHASE22021-01-11ClinicalTrials.gov
NCT01751152NNC0114-0006PHASE2ClinicalTrials.gov
NCT01689025NNC0114-0006PHASE1ClinicalTrials.gov
NCT01647451NNC0114-0006PHASE2ClinicalTrials.gov
NCT01565408NNC0114-0006PHASE1ClinicalTrials.gov

NIH grants 7560

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant922,025NIH's project files
P30CA008748Cancer Center Support Grant642,025NIH's project files
P51OD011132Emory National Primate Research Center482,025NIH's project files
ZIAHL005408IL-2 Family Cytokines and their Receptors-- Biology of the IL-21 system422,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award392,025NIH's project files
ZIAAR041159Cytokine Signaling, Immunoregulation and Autoimmune and Immunodeficiency Diseases382,025NIH's project files
R01HL117913The NOTCH Signaling Pathway in Large Vessel Vasculitis312,025NIH's project files
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies302,025NIH's project files
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged292,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro272,025NIH's project files

Papers 16169

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818144PubTator, text miningPubMed
42782420PubTator, text miningPubMed
42780644PubTator, text miningPubMed
42777708PubTator, text miningPubMed
42765849PubTator, text miningPubMed
42764195PubTator, text miningPubMed
42732976PubTator, text miningPubMed
42731396PubTator, text miningPubMed
42715569PubTator, text miningPubMed
42712421PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license