Gene · 5908
RAP1B: RAP1B, member of RAS oncogene family
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RAP1B: RAP1B, member of RAS oncogene family. Genes, record 5908. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5908
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P61224 | Ras-related protein Rap-1b | 184 | 23 | Ensembl, GeneID, HGNC |
Source UniProt
Patents61
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 60949 | P61224 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60950 | P61224 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60952 | P61224 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 60960 | P61224 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1315 | P61224 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1315 | P61224 | Espacenet |
| US 12181474 B2 | 2024-12-31 | 8 | P61224 | Espacenet |
| JP 2023064789 A | 2023-05-12 | 76 | P61224 | Espacenet |
| WO 2023074712 A | 2023-05-04 | 22 | P61224 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 71586 | P61224 | Espacenet |
1 to 10 of 61
See all 61 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants993
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RAP1B papers | Newest fiscal year |
|---|---|---|---|
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P30EY014800 | University of Utah Core Vision Research Grant | 3 | 2025 |
| R01AI141009 | Role of clonal expansion in HIV-1 persistence | 3 | 2025 |
| R01EY017011 | Endothelial Transmigration in Neovascular Age-related Macular Degeneration | 3 | 2025 |
| R35HL144976 | Small GTPases in the biology of platelets and megakaryocytes | 3 | 2025 |
| R37AI147868 | The HUSH complex in HIV-1 latency | 3 | 2025 |
| P01AI091580 | Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR | 2 | 2025 |
1 to 10 of 993Source NIH's project files
See all 993 nih grantsPapers1,432
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Proteomics reveal serum biomarkers for early diagnosis in premature ovarian insufficiency. | Front Endocrinol (Lausanne) | 2026 | 42824073 | PubTator, text mining | PubMed |
| Mechanism of microRNA-30b-5p enhancing the response of MDA-MB-231 cells to cisplatin by regulating RAP1B expression. | Exp Ther Med | 2026 | 42682842 | PubTator, text mining | PubMed |
| Cancer‑associated fibroblast‑derived extracellular vesicles promote pancreatic cancer progression via the RAP1B/ANLN axis. | Oncol Rep | 2026 | 42627065 | PubTator, text mining | PubMed |
| A model for PIP2/3 and Rnd1 effects on Plexin-B1 GAP activity on Rap1b GTPase derived from molecular dynamics simulations. | bioRxiv | 2026 | 42523502 | PubTator, text mining | PubMed |
| Extracellular vesicle cargo dynamics in the bone marrow microenvironment: from hematopoietic homeostasis to malignant transformation. | Extracell Vesicle | 2026 | 42344609 | PubTator, text mining | PubMed |
| Lipid droplet-associated gene signatures classify metabolic subtypes and identify PLIN3 as a key driver in hepatocellular carcinoma. | Genes Dis | 2026 | 42327977 | PubTator, text mining | PubMed |
| Targeting Rap1-YAP1 mechanosignaling for ameliorating acute IOP elevation-induced trabecular meshwork dysfunction. | iScience | 2026 | 42291280 | PubTator, text mining | PubMed |
| Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy. | Acta Pharmacol Sin | 2026 | 42252304 | PubTator, text mining | PubMed |
| An integrated peripheral immune circuit of inflammation and dysfunction underlies drug resistance in pediatric drug-resistant epilepsy. | J Transl Med | 2026 | 42210363 | PubTator, text mining | PubMed |
| Rap1b Activates Endosomal AC9 to Drive the Second cAMP Wave. | bioRxiv | 2026 | 42182323 | PubTator, text mining | PubMed |
1 to 10 of 1,432
See all 1,432 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5908
GET https://conductscience.org/api/genes/v1/5908/patents?page=2