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Gene · 5908

RAP1B: RAP1B, member of RAS oncogene family

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RAP1B: RAP1B, member of RAS oncogene family. Genes, record 5908. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5908

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Gene

Symbol
RAP1B
HGNC
Name
RAP1B, member of RAS oncogene family
HGNC
NCBI Gene ID
5908
NCBI Gene
HGNC ID
HGNC:9857
HGNC
Ensembl
ENSG00000127314
NCBI Gene
Aliases
DKFZp586H0723, K-REV, RAL1B, THC11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61224Ras-related protein Rap-1b18423Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460949P61224Espacenet
JP 2026004568 A2026-01-1460950P61224Espacenet
JP 2026004568 A2026-01-1460952P61224Espacenet
JP 2026004568 A2026-01-1460960P61224Espacenet
EP 4650780 A22025-11-191315P61224Espacenet
JP 2025517970 A2025-06-121315P61224Espacenet
US 12181474 B22024-12-318P61224Espacenet
JP 2023064789 A2023-05-1276P61224Espacenet
WO 2023074712 A2023-05-0422P61224Espacenet
US 11446398 B22022-09-2071586P61224Espacenet

1 to 10 of 61

See all 61 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants993

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRAP1B papersNewest fiscal year
P30CA016086Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
P30CA008748Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant32025
P30EY014800University of Utah Core Vision Research Grant32025
R01AI141009Role of clonal expansion in HIV-1 persistence32025
R01EY017011Endothelial Transmigration in Neovascular Age-related Macular Degeneration32025
R35HL144976Small GTPases in the biology of platelets and megakaryocytes32025
R37AI147868The HUSH complex in HIV-1 latency32025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR22025

1 to 10 of 993Source NIH's project files

See all 993 nih grants

Papers1,432

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Proteomics reveal serum biomarkers for early diagnosis in premature ovarian insufficiency.Front Endocrinol (Lausanne)202642824073PubTator, text miningPubMed
Mechanism of microRNA-30b-5p enhancing the response of MDA-MB-231 cells to cisplatin by regulating RAP1B expression.Exp Ther Med202642682842PubTator, text miningPubMed
Cancer‑associated fibroblast‑derived extracellular vesicles promote pancreatic cancer progression via the RAP1B/ANLN axis.Oncol Rep202642627065PubTator, text miningPubMed
A model for PIP2/3 and Rnd1 effects on Plexin-B1 GAP activity on Rap1b GTPase derived from molecular dynamics simulations.bioRxiv202642523502PubTator, text miningPubMed
Extracellular vesicle cargo dynamics in the bone marrow microenvironment: from hematopoietic homeostasis to malignant transformation.Extracell Vesicle202642344609PubTator, text miningPubMed
Lipid droplet-associated gene signatures classify metabolic subtypes and identify PLIN3 as a key driver in hepatocellular carcinoma.Genes Dis202642327977PubTator, text miningPubMed
Targeting Rap1-YAP1 mechanosignaling for ameliorating acute IOP elevation-induced trabecular meshwork dysfunction.iScience202642291280PubTator, text miningPubMed
Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy.Acta Pharmacol Sin202642252304PubTator, text miningPubMed
An integrated peripheral immune circuit of inflammation and dysfunction underlies drug resistance in pediatric drug-resistant epilepsy.J Transl Med202642210363PubTator, text miningPubMed
Rap1b Activates Endosomal AC9 to Drive the Second cAMP Wave.bioRxiv202642182323PubTator, text miningPubMed

1 to 10 of 1,432

See all 1,432 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5908

GET https://conductscience.org/api/genes/v1/5908/patents?page=2