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Gene · 5921

RASA1: RAS p21 protein activator 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RASA1: RAS p21 protein activator 1. Genes, record 5921. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5921

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Gene

Symbol
RASA1
HGNC
Name
RAS p21 protein activator 1
HGNC
NCBI Gene ID
5921
NCBI Gene
HGNC ID
HGNC:9871
HGNC
Ensembl
ENSG00000145715
NCBI Gene
Aliases
CM-AVM, CMAVM, CMAVM1, GAP, PKWS, RASA, RASGAP, p120, p120GAP, p120RASGAP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20936Ras GTPase-activating protein 11,04715Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192903P20936Espacenet
EP 4641201 A22025-10-292468P20936Espacenet
JP 2025517969 A2025-06-122468P20936Espacenet
JP 2025517970 A2025-06-122903P20936Espacenet
JP 2024123008 A2024-09-108123P20936Espacenet
JP 2023123507 A2023-09-05289P20936Espacenet
US 11446398 B22022-09-2071877P20936Espacenet
JP 2022524081 A2022-04-27174848P20936Espacenet
US 11078247 B22021-08-039375P20936Espacenet
JP 2020524809 A2020-08-20289P20936Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,330

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRASA1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant412025
P30CA016672Cancer Center Support Grant172025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR92025
ZIACL080017IQGAP1 in tumorigenesis92025
P30CA014195Cancer Center Support Grant (CCSG)72025
P30CA016086Cancer Center Support Grant62025
R35GM118177Excitable Networks in Directed Cell Migration62025
ZIABC010440Protein Structure, Stability, and Amyloid Formation62025
P30CA006973Regional Oncology Research Center52025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025

1 to 10 of 2,330Source NIH's project files

See all 2,330 nih grants

Papers3,549

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ras protein activator-like 3 is a key Ras GTPase-activating protein that protects the survival and anti-tumor activity of CD8+ T cells.Front Immunol202642819241PubTator, text miningPubMed
Clinical and molecular characterization of non-PIK3CA-related vascular malformations with overgrowth in a pediatric cohort.World J Pediatr202642814223PubTator, text miningPubMed
Macrophage phagocytosis checkpoints in DLBCL immunotherapy: an evidence-maturity framework from CD47 to CD200.Front Oncol202642798844PubTator, text miningPubMed
New Biochemical Insights into RIT GTPases Regulation and Membrane Interactions.Cells202642738861PubTator, text miningPubMed
Management of Combined Vascular Malformations.Clin Plast Surg202642680450PubTator, text miningPubMed
Changes in Ras and Ras-Associated GTPases During Maturation of Porcine Cumulus Cells and Oocytes.Animals (Basel)202642511004PubTator, text miningPubMed
Cardiac remodelling and dysfunction in cancer patients receiving cardiotoxic therapies: proteomic and metabolomic profiling.Eur Heart J202642366805PubTator, text miningPubMed
Capillary Malformation-Arteriovenous Malformation Syndrome Associated with RASA1 and EPHB4 Mutations: Comparative Case Series and Narrative Review.Life (Basel)202642355527PubTator, text miningPubMed
MiR-31 as a predictive biomarker of cetuximab efficacy in metastatic colorectal cancer patients: systematic review.Clin Transl Oncol202642315817PubTator, text miningPubMed
The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling in Drosophila.Front Endocrinol (Lausanne)202642244947PubTator, text miningPubMed

1 to 10 of 3,549

See all 3,549 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5921

GET https://conductscience.org/api/genes/v1/5921/patents?page=2