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Gene · 5927

KDM5A: lysine demethylase 5A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KDM5A: lysine demethylase 5A. Genes, record 5927. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5927

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Gene

Symbol
KDM5A
HGNC
Name
lysine demethylase 5A
HGNC
NCBI Gene ID
5927
NCBI Gene
HGNC ID
HGNC:9886
HGNC
Ensembl
ENSG00000073614
NCBI Gene
Aliases
JARID1A, NEDEHC, RBBP-2, RBBP2, RBP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P29375Lysine-specific demethylase 5A1,69046Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452088P29375Espacenet
EP 4650780 A22025-11-1911682P29375Espacenet
EP 4641201 A22025-10-2912340P29375Espacenet
JP 2025147176 A2025-10-0615201P29375Espacenet
JP 2025517969 A2025-06-1212340P29375Espacenet
JP 2025517970 A2025-06-1211682P29375Espacenet
JP 2025028160 A2025-02-2815201P29375Espacenet
KR 1020250010750 A2025-01-2115201P29375Espacenet
JP 2024109657 A2024-08-1415040P29375Espacenet
US 11446398 B22022-09-2047741P29375Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,354

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKDM5A papersNewest fiscal year
P30CA008748Cancer Center Support Grant152025
R01CA198279Shaping DNA Damage Response Networks Via Histone H2A Variants122025
P30CA016672Cancer Center Support Grant112025
P30CA016359Cancer Center Support Grant102025
P30CA021765Cancer Center Support Grant (CCSG)92025
P30CA006927Comprehensive Cancer Center Program at Fox Chase82025
U10CA180899Children's Oncology Group Statistics and Data Center82025
UL1TR001863Yale Clinical and Translational Science Award82025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement72025
P30CA013330Cancer Center Support Grant62025

1 to 10 of 1,354Source NIH's project files

See all 1,354 nih grants

Papers1,684

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Field-ridge structured bioactive Zn-based scaffold promotes bone regeneration via cellular mechanotransduction.Bioact Mater202742598026PubTator, text miningPubMed
UBR5-KDM5A axis rewires redox metabolism to confer cisplatin resistance in triple-negative breast cancer via the cAMP-PKA-SIRT3 cascade.Drug Resist Updat202642809895PubTator, text miningPubMed
The RBP2-BECN1-VEGFA axis orchestrates a self-amplifying circuit to drive malignant progression in gastric carcinoma.Front Oncol202642769169PubTator, text miningPubMed
HIF1α-KLF4 signaling dictates extra-erythrocyte expression of hemoglobin conferring sorafenib resistance in hepatocellular carcinoma.Signal Transduct Target Ther202642744801PubTator, text miningPubMed
Identification and characterisation of a novel homozygous KDM5A variant associated with severe axial hypotonia, seizures, and cardiac anomalies.J Hum Genet202642618742PubTator, text miningPubMed
Rb-driven transcription limits its tumour-suppressive effects in breast cancer.Nature202642587147PubTator, text miningPubMed
[Analysis of Genetic Characteristics and Clinical Efficacy in Pediatric Acute Myeloid Leukemia with NUP98∷KDM5A Fusion Gene Positive].Zhongguo Shi Yan Xue Ye Xue Za Zhi202642544647PubTator, text miningPubMed
Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses.EBioMedicine202642481375PubTator, text miningPubMed
CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks.Nucleic Acids Res202642475683PubTator, text miningPubMed
Targeting galactose metabolic reprogramming overcomes immunotherapy resistance in KRAS-mutant lung adenocarcinoma: Integrative multi-omics and machine learning approaches.Transl Oncol202642407377PubTator, text miningPubMed

1 to 10 of 1,684

See all 1,684 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5927

GET https://conductscience.org/api/genes/v1/5927/patents?page=2