Gene · 5927
KDM5A: lysine demethylase 5A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KDM5A: lysine demethylase 5A. Genes, record 5927. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5927
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P29375 | Lysine-specific demethylase 5A | 1,690 | 46 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 52088 | P29375 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 11682 | P29375 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 12340 | P29375 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15201 | P29375 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 12340 | P29375 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 11682 | P29375 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15201 | P29375 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15201 | P29375 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15040 | P29375 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 47741 | P29375 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,354
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KDM5A papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 15 | 2025 |
| R01CA198279 | Shaping DNA Damage Response Networks Via Histone H2A Variants | 12 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P30CA016359 | Cancer Center Support Grant | 10 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 9 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 8 | 2025 |
| U10CA180899 | Children's Oncology Group Statistics and Data Center | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 8 | 2025 |
| U10CA180886 | COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement | 7 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 1,354Source NIH's project files
See all 1,354 nih grantsPapers1,684
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Field-ridge structured bioactive Zn-based scaffold promotes bone regeneration via cellular mechanotransduction. | Bioact Mater | 2027 | 42598026 | PubTator, text mining | PubMed |
| UBR5-KDM5A axis rewires redox metabolism to confer cisplatin resistance in triple-negative breast cancer via the cAMP-PKA-SIRT3 cascade. | Drug Resist Updat | 2026 | 42809895 | PubTator, text mining | PubMed |
| The RBP2-BECN1-VEGFA axis orchestrates a self-amplifying circuit to drive malignant progression in gastric carcinoma. | Front Oncol | 2026 | 42769169 | PubTator, text mining | PubMed |
| HIF1α-KLF4 signaling dictates extra-erythrocyte expression of hemoglobin conferring sorafenib resistance in hepatocellular carcinoma. | Signal Transduct Target Ther | 2026 | 42744801 | PubTator, text mining | PubMed |
| Identification and characterisation of a novel homozygous KDM5A variant associated with severe axial hypotonia, seizures, and cardiac anomalies. | J Hum Genet | 2026 | 42618742 | PubTator, text mining | PubMed |
| Rb-driven transcription limits its tumour-suppressive effects in breast cancer. | Nature | 2026 | 42587147 | PubTator, text mining | PubMed |
| [Analysis of Genetic Characteristics and Clinical Efficacy in Pediatric Acute Myeloid Leukemia with NUP98∷KDM5A Fusion Gene Positive]. | Zhongguo Shi Yan Xue Ye Xue Za Zhi | 2026 | 42544647 | PubTator, text mining | PubMed |
| Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses. | EBioMedicine | 2026 | 42481375 | PubTator, text mining | PubMed |
| CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks. | Nucleic Acids Res | 2026 | 42475683 | PubTator, text mining | PubMed |
| Targeting galactose metabolic reprogramming overcomes immunotherapy resistance in KRAS-mutant lung adenocarcinoma: Integrative multi-omics and machine learning approaches. | Transl Oncol | 2026 | 42407377 | PubTator, text mining | PubMed |
1 to 10 of 1,684
See all 1,684 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5927
GET https://conductscience.org/api/genes/v1/5927/patents?page=2