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Gene · 593

BCKDHA: branched chain keto acid dehydrogenase E1 subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BCKDHA: branched chain keto acid dehydrogenase E1 subunit alpha. Genes, record 593. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/593

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Gene

Symbol
BCKDHA
HGNC
Name
branched chain keto acid dehydrogenase E1 subunit alpha
HGNC
NCBI Gene ID
593
NCBI Gene
HGNC ID
HGNC:986
HGNC
Ensembl
ENSG00000248098
NCBI Gene
Aliases
BCKDE1A, MSU, MSUD1, MSUD1A, OVD1A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P126942-oxoisovalerate dehydrogenase subunit alpha, mitochondrial44524Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-2164P12694Espacenet
JP 2026004568 A2026-01-1439127P12694Espacenet
EP 4650780 A22025-11-192725P12694Espacenet
EP 4641201 A22025-10-292313P12694Espacenet
JP 2025517969 A2025-06-122313P12694Espacenet
JP 2025517970 A2025-06-122725P12694Espacenet
JP 2025062604 A2025-04-149492P12694Espacenet
JP 2023123507 A2023-09-05111P12694Espacenet
JP 2023521663 A2023-05-2563P12694Espacenet
US 11446398 B22022-09-209492P12694Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,126

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBCKDHA papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30CA014051Cancer Center Support (Core) Grant42025
P30CA008748Cancer Center Support Grant32025
P30CA010815Consolidated Basic Cancer Research Program32025
R01NS076991Oligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and Leukodystrophies32025
R35CA242379Understanding the role of metabolism in cancer32025
P30CA012197Cancer Center Support Grant22025
P30CA016058Cancer Center Support Grant22025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202822025
P30CA068485Cancer Center Support Grant22025

1 to 10 of 1,126Source NIH's project files

See all 1,126 nih grants

Papers1,659

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lauric acid engages an O-GlcNAc-sensitive BCKDH regulatory node to modulate branched-chain amino acid oxidation in skeletal myotubes.J Biol Chem202642463056PubTator, text miningPubMed
Total glucosides of paeony modulates leucine metabolism by inhibiting SLC7A5, antagonizing mTOR signaling to suppress head and neck squamous cell carcinoma.Phytomedicine202642462529PubTator, text miningPubMed
Identification of neoadjuvant chemoradiotherapy resistance-associated proteins in locally advanced rectal cancer: A pilot study.Oncol Lett202642395269PubTator, text miningPubMed
N-acetyltransferase 10 participates in dopaminergic neuronal apoptosis in Parkinson's disease through ac4C-mediated transcriptomic regulation.Brain Res Bull202642242584PubTator, text miningPubMed
IDH3A Deficiency Compromises Adaptive Thermogenesis and Exacerbates Obesity-Induced Metabolic Dysfunction via Impaired BCKDHA-Dependent BCAA Catabolism.Diabetes202642008693PubTator, text miningPubMed
3-Methylcrotonyl-CoA Carboxylase Expression Among Astrocytes and Neurons in the Human Brain and the Effect of Hyperglycemia on the Catabolic Flux of 13C6, 15N-Leucine in Cultured Astrocytes.Neurochem Res202641854924PubTator, text miningPubMed
BCAAs and related metabolic enzymes: partners in crime driving tumor development.Front Cell Dev Biol202641769003PubTator, text miningPubMed
Isogenic cortical organoids enable precision targeting of APP variant-specific pathways in Alzheimer's disease.bioRxiv202641757078PubTator, text miningPubMed
The Inevitable Relationship Between Viruses and RNA Modifications Revealed Through Adenovirus Research.Viruses202641754586PubTator, text miningPubMed
Clinical Profiles, Genetic Variants, and Neurodevelopmental Outcomes Following Liver Transplantation in Maple Syrup Urine Disease: A Study From Palestine.JIMD Rep202641737903PubTator, text miningPubMed

1 to 10 of 1,659

See all 1,659 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/593

GET https://conductscience.org/api/genes/v1/593/patents?page=2