Gene · 593
BCKDHA: branched chain keto acid dehydrogenase E1 subunit alpha
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BCKDHA: branched chain keto acid dehydrogenase E1 subunit alpha. Genes, record 593. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/593
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P12694 | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 445 | 24 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 64 | P12694 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 39127 | P12694 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2725 | P12694 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2313 | P12694 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2313 | P12694 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2725 | P12694 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 9492 | P12694 | Espacenet |
| JP 2023123507 A | 2023-09-05 | 111 | P12694 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 63 | P12694 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 9492 | P12694 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,126
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BCKDHA papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 3 | 2025 |
| R01NS076991 | Oligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and Leukodystrophies | 3 | 2025 |
| R35CA242379 | Understanding the role of metabolism in cancer | 3 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 2 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 2 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,126Source NIH's project files
See all 1,126 nih grantsPapers1,659
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Lauric acid engages an O-GlcNAc-sensitive BCKDH regulatory node to modulate branched-chain amino acid oxidation in skeletal myotubes. | J Biol Chem | 2026 | 42463056 | PubTator, text mining | PubMed |
| Total glucosides of paeony modulates leucine metabolism by inhibiting SLC7A5, antagonizing mTOR signaling to suppress head and neck squamous cell carcinoma. | Phytomedicine | 2026 | 42462529 | PubTator, text mining | PubMed |
| Identification of neoadjuvant chemoradiotherapy resistance-associated proteins in locally advanced rectal cancer: A pilot study. | Oncol Lett | 2026 | 42395269 | PubTator, text mining | PubMed |
| N-acetyltransferase 10 participates in dopaminergic neuronal apoptosis in Parkinson's disease through ac4C-mediated transcriptomic regulation. | Brain Res Bull | 2026 | 42242584 | PubTator, text mining | PubMed |
| IDH3A Deficiency Compromises Adaptive Thermogenesis and Exacerbates Obesity-Induced Metabolic Dysfunction via Impaired BCKDHA-Dependent BCAA Catabolism. | Diabetes | 2026 | 42008693 | PubTator, text mining | PubMed |
| 3-Methylcrotonyl-CoA Carboxylase Expression Among Astrocytes and Neurons in the Human Brain and the Effect of Hyperglycemia on the Catabolic Flux of 13C6, 15N-Leucine in Cultured Astrocytes. | Neurochem Res | 2026 | 41854924 | PubTator, text mining | PubMed |
| BCAAs and related metabolic enzymes: partners in crime driving tumor development. | Front Cell Dev Biol | 2026 | 41769003 | PubTator, text mining | PubMed |
| Isogenic cortical organoids enable precision targeting of APP variant-specific pathways in Alzheimer's disease. | bioRxiv | 2026 | 41757078 | PubTator, text mining | PubMed |
| The Inevitable Relationship Between Viruses and RNA Modifications Revealed Through Adenovirus Research. | Viruses | 2026 | 41754586 | PubTator, text mining | PubMed |
| Clinical Profiles, Genetic Variants, and Neurodevelopmental Outcomes Following Liver Transplantation in Maple Syrup Urine Disease: A Study From Palestine. | JIMD Rep | 2026 | 41737903 | PubTator, text mining | PubMed |
1 to 10 of 1,659
See all 1,659 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/593
GET https://conductscience.org/api/genes/v1/593/patents?page=2